• APOE status and its association to learning and memory performance in middle aged and older Norwegians seeking assessment for memory deficits 

      Wehling, Eike Ines; Lundervold, Astri Johansen; Standnes, Brit; Gjerstad, Leif; Reinvang, Ivar (Peer reviewed; Journal article, 2007-10-31)
      Background: We examined the hypothesis that deficits in learning, memory, and other cognitive functions are associated with the ε4 allele of the Apolipoprotein E (APOE) gene in a non-demented sample with memory complaints ...
    • Common variants in the ARC gene are not associated with cognitive abilities 

      Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Peer reviewed; Journal article, 2015-09-03)
      Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ...
    • Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders 

      Ersland, Kari Merete; Christoforou, Andrea; Stansberg, Christine; Espeseth, Thomas; Mattheisen, Manuel; Mattingsdal, Morten; Hardarson, Gudmundur A.; Hansen, Thomas; Fernandes, Carla P. D.; Giddaluru, Sudheer; Breuer, René; Strohmaier, Jana; Djurovic, Srdjan; Nöthen, Markus M.; Rietschel, Marcella; Lundervold, Astri Johansen; Werge, Thomas; Cichon, Sven; Andreassen, Ole Andreas; Reinvang, Ivar; Steen, Vidar Martin; Le Hellard, Stephanie (Peer reviewed; Journal article, 2012-02-22)
      Background: Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive ...
    • Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) 

      Davies, Gail; Armstrong, N; Bis, JC; Bressler, J; Chouraki, V; Giddaluru, Sudheer; Hofer, E; Ibrahim-Verbaas, CA; Kirin, M; Lahti, J; Van Der Lee, SJ; Le Hellard, Stephanie; Liu, T; Marioni, RE; Oldmeadow, C; Postmus, I; Smith, AV; Smith, JA; Thalamuthu, A; Thomson, R; Vitart, V; Wang, J; Yu, L; Zgaga, L; Zhao, W; Boxall, R; Harris, SE; Hill, WD; Liewald, DC; Luciano, M; Adams, H; Ames, D; Amin, N; Amouyel, P; Assareh, AA; Au, R; Becker, JT; Beiser, A; Berr, C; Bertram, L; Boerwinkle, E; Buckley, BM; Campbell, H; Corley, J; De Jager, PL; Dufouil, C; Eriksson, JG; Espeseth, Thomas; Faul, JD; Ford, I; Scotland, Generation; Gottesman, RF; Griswold, ME; Gudnason, V; Harris, TB; Heiss, G; Hofman, A; Holliday, EG; Huffman, J; Kardia, SLR; Kochan, N; Knopman, DS; Kwok, JB; Lambert, JC; Lee, T; Li, G; Li, SC; Loitfelder, M; Lopez, OL; Lundervold, Astri; Lundqvist, A; Mather, KA; Mirza, SS; Nyberg, L; Oostra, BA; Palotie, A; Papenberg, G; Pattie, A; Petrovic, K; Polasek, O; Psaty, BM; Redmond, P; Reppermund, S; Rotter, JI; Schmidt, H; Schuur, M; Schofield, PW; Scott, RJ; Steen, Vidar Martin; Stott, DJ; Van Swieten, JC; Taylor, KD; Trollor, J; Trompet, S; Uitterlinden, AG; Weinstein, G; Widen, E; Windham, BG; Jukema, JW; Wright, AF; Wright, MJ; Yang, Q; Amieva, H; Attia, JR; Bennett, DA; Brodaty, H; De Craen, AJM; Hayward, C; Ikram, MA; Lindenberger, U; Nilsson, LG; Porteous, DJ; Räikkönen, K; Rudan, I; Sachdev, PS; Schmidt, R; Schofield, PR; Srikanth, V; Starr, JM; Turner, ST; Weir, DR; Wilson, JF; Van Duijn, C; Launer, L; Fitzpatrick, AL; Seshadri, S; Mosley, TH; Deary, IJ; Reinvang, Ivar (Peer reviewed; Journal article, 2015)
      General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait ...
    • GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortium 

      Trampush, Joey W.; Yang, M.L.Z.; Yu, Jin; Knowles, Emma; Davies, Gail; Liewald, David C.M.; Starr, John M.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan Gunnar; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William E.R.; Horan, Michael Arthur; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth Trilby; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios A.; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert Martin; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edyth; Poldrack, Russell Alan; Sabb, Fred W.; Congdon, Eliza L.; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary J.; Morris, Derek W.; Corvin, Aiden; Gill, Michael; Hariri, Ahmad; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian John; Glahn, David C.; Malhotra, Anil K.; Lencz, Todd (Peer reviewed; Journal article, 2017-01-17)
      The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these ...
    • GWAS-based pathway analysis differentiates between fluid and crystallized intelligence 

      Christoforou, Andrea; Espeseth, Thomas; Davis, G.; Fernandes, Carla P.D.; Giddaluru, Sudheer; Mattheisen, Manuel; Tenesa, A.; Harris, Sarah E.; Liewald, David C; Payton, Anthony; Ollier, W; Horan, M.; Pendleton, Neil; Haggarty, Paul; Djurovic, Srdjan; Herms, Stefan; Hoffman, P.; Cichon, Sven; Starr, John M; Lundervold, Astri; Reinvang, Ivar; Steen, Vidar Martin; Deary, Ian J; Le Hellard, Stephanie (Peer reviewed; Journal article, 2014-09)
      Cognitive abilities vary among people. About 40–50% of this variability is due to general intelligence (g), which reflects the positive correlation among individuals' scores on diverse cognitive ability tests. g is positively ...
    • Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins 

      Hill, Wayne David; Davies, Gail; Van De Lagemaat, Louie N.; Christoforou, Andrea; Marioni, Riccardo R.; Duarte Fernandes, Carla; Liewald, David Cherry; Croning, Mike D.R.; Payton, Anthony; Craig, Leone C.A.; Whalley, Lawrence J.; Horan, Michael; Ollier, William E.R.; Hansell, Narelle K.; Wright, Margaret J.; Martin, Nicholas G.; Montgomery, Grant W.; Steen, Vidar Martin; Le Hellard, Stephanie; Espeseth, Thomas; Lundervold, Astri; Reinvang, Ivar; Starr, John M.; Pendleton, Neil; Grant, Seth G.N.; Bates, Timothy C.; Deary, Ian John (Peer reviewed; Journal article, 2014)
      Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide ...
    • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function 

      Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C.M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L.K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; Derosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole Andreas; Armstrong, Nicola J.; Assareh, Amelia A; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L.R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Liu, Tian; Koini, Marisa; London, Edythe; Longstreth, Will T.; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Göran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil Søren; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widén, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H.H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Corvin, Aiden; De Jager, Philip L.; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar Martin; Trollor, Julian N.; Turner, Steven T.; Van Duijn, Cornelia M.; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Mosley, Thomas H.; Bressler, Jan; Lencz, Todd; Deary, Ian J. (Peer reviewed; Journal article, 2018)
      General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank ...