Blar i Bergen Open Research Archive på forfatter "Rentzsch, Fabian"
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Development of the aboral domain in Nematostella requires β-catenin and the opposing activities of Six3/6 and Frizzled5/8
Leclere, Lucas Pierre Jean; Bause, Markus; Sinigaglia, Chiara; Steger, Julia; Rentzsch, Fabian (Journal article; Peer reviewed, 2016-03)The development of the oral pole in cnidarians and the posterior pole in bilaterians is regulated by canonical Wnt signaling, whereas a set of transcription factors, including Six3/6 and FoxQ2, controls aboral development ... -
Evolution of eumetazoan nervous systems: Insights from cnidarians
Kelava, Iva; Rentzsch, Fabian; Technau, Ulrich (Journal article; Peer reviewed, 2015-12-19)Cnidarians, the sister group to bilaterians, have a simple diffuse nervous system. This morphological simplicity and their phylogenetic position make them a crucial group in the study of the evolution of the nervous system. ... -
Generating transgenic reporter lines for studying nervous system development in the cnidarian nematostella vectensis
Rentzsch, Fabian; Renfer, Eduard; Technau, Ulrich (Journal article; Peer reviewed, 2020)Neurons often display complex morphologies with long and fine processes that can be difficult to visualize, in particular in living animals. Transgenic reporter lines in which fluorescent proteins are expressed in defined ... -
The genetic basis for PRC1 complex diversity emerged early in animal evolution
Gahan, James; Rentzsch, Fabian; Schnitzler, Christine E. (Journal article; Peer reviewed, 2020)Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about ... -
Glypican1/2/4/6 and sulfated glycosaminoglycans regulate the patterning of the primary body axis in the cnidarian Nematostella vectensis
Bause, Markus; van der Horst, Roddy; Rentzsch, Fabian (Journal article; Peer reviewed, 2016-06)Glypicans are members of the heparan sulfate (HS) subfamily of proteoglycans that can function in cell adhesion, cell crosstalk and as modulators of the major developmental signalling pathways in bilaterians. The evolutionary ... -
Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis
Gahan, James Michael; Kouzel, Ivan; Ormevik Jansen, Kamilla; Burkhardt, Pawel; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ... -
Modern genomic tools reveal the structural and cellular diversity of cnidarian nervous systems
Rentzsch, Fabian; Juliano, Celina; Galliot, Brigitte (Peer reviewed; Journal article, 2019)Cnidarians shared a common ancestor with bilaterians more than 600 million years ago. This sister group relationship gives them an informative phylogenetic position for understanding the fascinating morphological and ... -
Molecular characterization of the apical organ of the anthozoan Nematostella vectensis
Sinigaglia, Chiara; Busengdal, Henriette; Lerner, Avi; Oliveri, Paola; Rentzsch, Fabian (Journal article; Peer reviewed, 2014-12-03)Apical organs are sensory structures present in many marine invertebrate larvae where they are considered to be involved in their settlement, metamorphosis and locomotion. In bilaterians they are characterised by a tuft ... -
NvPOU4/Brain3 Functions as a Terminal Selector Gene in the Nervous System of the Cnidarian Nematostella vectensis
Tourniere, Oceane Barbara; Dolan, David William Peter; Richards, Gemma Sian; Sunagar, Kartik; Columbus-Shenkar, Yaara Y; Moran, Yehu; Rentzsch, Fabian (Journal article; Peer reviewed, 2020-03)Terminal selectors are transcription factors that control the morphological, physiological, and molecular features that characterize distinct cell types. Here, we show that, in the sea anemone Nematostella vectensis, NvPOU4 ... -
Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
Richards, Gemma Sian; Rentzsch, Fabian (Journal article; Peer reviewed, 2015-10-06)Notch signalling, SoxB and Group A bHLH ‘proneural’ genes are conserved regulators of the neurogenic program in many bilaterians. However, the ancestry of their functions and interactions is not well understood. We address ...