Blar i Bergen Open Research Archive på forfatter "Riley, John H."
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Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease
Qiu, Weiliang; Cho, Michael H.; Riley, John H.; Anderson, Wayne H.; Singh, Dave; Bakke, Per; Gulsvik, Amund; Litonjua, Augusto A.; Lomas, David A.; Crapo, James D.; Beaty, Terri H.; Celli, Bartolome R.; Rennard, Stephen I.; Tal-Singer, Ruth; Fox, Steven M.; Silverman, Edwin K.; Hersh, Craig P. (Peer reviewed; Journal article, 2011-09-16)Previous expression quantitative trait loci (eQTL) studies have performed genetic association studies for gene expression, but most of these studies examined lymphoblastoid cell lines from non-diseased individuals. We ... -
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; Ericsson, Magnus; Pohanka, Anton; James, Anna; Andersson, Lars I.; Sparreman-Mikus, Maria; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Bakke, Per S.; Kermani, Nazanin Zounemat; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter H.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E.; Knowles, Richard G.; Dahlén, Barbro; van der Zee, Anke-Hilse Maitland; Sterk, Peter J.; Djukanovic, Ratko; Adcock, Ian M.; Chung, Kian Fan; Wheelock, Craig E.; Dahlén, Sven-Erik; Jonsson, Eva Wikström (Journal article; Peer reviewed, 2023)Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ... -
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
Mikus, Maria Sparreman; Kolmert, Johan; Andersson, Lars I.; Östling, Jörgen; Knowles, Richard G.; Gómez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Khoonsari, Payam Emami; Dahlén, Barbro; Kupczyk, Maciej; de Meulder, Bertrand; Auffray, Charles; Bakke, Per S.; Beghe, Bianca; Bel, Elisabeth H.; Caruso, Massimo; Chanez, Pascal; Chawes, Bo; Fowler, Stephen J.; Gaga, Mina; Geiser, Thomas; Gjomarkaj, Mark; Horváth, Ildikó; Howarth, Peter H.; Johnston, Sebastian L.; Joos, Guy; Krug, Norbert; Montuschi, Paolo; Musial, Jacek; Niżankowska-Mogilnicka, Ewa; Olsson, Henric K.; Papi, Alberto; Rabe, Klaus F.; Sandström, Thomas; Shaw, Dominick E.; Siafakas, Nikolaos M.; Uhlén, Mathias; Riley, John H.; Bates, Stewart; Middelveld, Roelinde J.M.; Wheelock, Craig E.; Chung, Kian Fan; Adcock, Ian M.; Sterk, Peter J.; Djukanovic, Ratko; Nilsson, Peter; Dahlén, Sven-Erik; James, Anna (Journal article; Peer reviewed, 2022)Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised ... -
Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation: A Clinical Observational Study
Kolmert, Johan; Gómez, Cristina; Balgoma, David; Sjödin, Marcus; Bood, Johan; Konradsen, Jon R.; Ericsson, Magnus; Thörngren, John-Olof; James, Anna; Mikus, Maria; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Bakke, Per S.; Pandis, Ioannis; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E.; Knowles, Richard G.; Holweg, Cécile T.J.; Wheelock, Åsa M.; Dahlen, Barbro; Nordlund, Björn; Alving, Kjell; Hedlin, Gunilla; Chung, Kian Fan; Adcock, Ian M.; Sterk, Peter J.; Djukanovic, Ratko; Dahlén, Sven-Erik; Wheelock, Craig E. (Journal article; Peer reviewed, 2021)Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins ... -
Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study
Reinke, Stacey N.; Naz, Shama; Chaleckis, Romanas; Gallart-Ayala, Hector; Kolmert, Johan; Kermani, Nazanin Z.; Tiotiu, Angelica; Broadhurst, David I.; Lundqvist, Anders; Olsson, Henric; Ström, Marika; Wheelock, Åsa M.; Gómez, Cristina; Ericsson, Magnus; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Scholfield, James; Loza, Matthew; Baribaud, Frédéric; Bakke, Per S.; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Behndig, Annelie; Singer, Florian; Musial, Jacek; Shaw, Dominick E.; Dahlén, Barbro; Hu, Sile; Lasky-Su, Jessica; Sterk, Peter J.; Chung, Kian Fan; Djukanovic, Ratko; Dahlén, Sven-Erik; Adcock, Ian M.; Wheelock, Craig E. (Journal article; Peer reviewed, 2022)Introduction Asthma is a heterogeneous disease with poorly defined phenotypes. Patients with severe asthma often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, ...