Browsing Bergen Open Research Archive by Author "Ritz, Christian"
Now showing items 1-15 of 15
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A 2-Dose AERAS-402 Regimen Boosts CD8+ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients
Sivakumaran, Dhanasekaran; Blatner, Gretta; Bakken, Rasmus; Hokey, David A.; Ritz, Christian; Jenum, Synne; Grewal, Harleen (Journal article; Peer reviewed, 2021)Despite the widespread use of BCG, tuberculosis (TB) remains a global threat. Existing vaccine candidates in clinical trials are designed to replace or boost BCG which does not provide satisfying long-term protection. ... -
Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis. Specific Immunity in Young Children
Jenum, Synne; Sivakumaran, Dhanasekaran; Ritz, Christian; Macaden, R; Doherty, TM; Grewal, Harleen; TB Trials Study, Group (Peer reviewed; Journal article, 2016)We have explored the added value of interferon-γ (IFNγ)– inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for ... -
Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum
Jenum, Synne; Sivakumaran, Dhanasekaran; Lodha, Rakesh; Mukherjee, Aparna; Saini, Deepak Kumar; Singh, Sarman; Singh, Varinder; Medigeshi, Guruprasad; Haks, Marielle C.; Ottenhoff, Tom H.M.; Doherty, Timothy Mark; Kabra, Sushil K.; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-01-04)The World Health Organization (WHO) calls for an accurate, rapid, and simple point-of-care (POC) test for the diagnosis of pediatric tuberculosis (TB) in order to make progress “Towards Zero Deaths”. Whereas the sensitivity ... -
BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome
Jenum, Synne; Bakken, Rasmus; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; Lodha, Rakesh; Singh, Sarman; Singh, Varinder; Haks, Marielle C.; Ottenhoff, Tom H.M.; Kabra, Sushil K.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-12-12)Biomarkers reflecting the extent of Mycobacterium tuberculosis-induced pathology and normalization during anti-tuberculosis treatment (ATT) would considerably facilitate trials of new treatment regimens and the identification ... -
The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemic
Serigstad, Sondre; Markussen, Dagfinn Lunde; Ritz, Christian; Ebbesen, Marit Helen; Knoop, Siri Tandberg; Kommedal, Øyvind; Heggelund, Lars; Ulvestad, Elling; Bjørneklett, Rune Oskar; Grewal, Harleen (Journal article; Peer reviewed, 2022-09-30)Background: The COVID-19 pandemic was met with strict containment measures. We hypothesized that societal infection control measures would impact the number of hospital admissions for respiratory tract infections, as well ... -
The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing
Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Serigstad, Sondre; Knoop, Siri Tandberg; Ritz, Christian; Bjørneklett, Rune Oskar; Kommedal, Øyvind; Jenum, Synne; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2023)This prospective study assessed the value of initial microscopy evaluation of sputum samples submitted for rapid syndromic PCR-based testing. Bacterial detections by the BioFire FilmArray Pneumonia Panel plus in 126 high- ... -
Host blood RNA transcript and protein signatures for sputum-independent diagnostics of tuberculosis in adults
Sivakumaran, Dhanasekaran; Ritz, Christian; Gjøen, John Espen; Vaz, Mario; Selvam, Sumithra; Ottenhoff, Tom H.M.; Doherty, Timothy Mark; Jenum, Synne; Grewal, Harleen (Journal article; Peer reviewed, 2021)To achieve the ambitious targets for tuberculosis (TB) prevention, care, and control stated by the End TB Strategy, new health care strategies, diagnostic tools are warranted. Host-derived biosignatures are explored for ... -
Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India
Sivakumaran, Dhanasekaran; Jenum, Synne; Srivastava, Aashish; Steen, Vidar Martin; Vaz, Mario; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Journal article; Peer reviewed, 2023-01-11)A large proportion of the global tuberculosis (TB) burden is asymptomatic and not detectable by symptom-based screening, driving the TB epidemic through continued M. tuberculosis transmission. Currently, no validated tools ... -
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
Siljan, William Ward; Sivakumaran, Dhanasekaran; Ritz, Christian; Jenum, Synne; Ottenhoff, Tom HM; Ulvestad, Elling; Holter, Jan Cato; Heggelund, Lars; Grewal, Harleen (Journal article; Peer reviewed, 2022)Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ... -
Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations
Bekken, Gry Klouman; Ritz, Christian; Selvam, Sumithra; Jesuraj, Nelson; Hesseling, Anneke; Doherty, T. Mark; Grewal, Harleen; Vaz, Mario; Jenum, Synne (Journal article; Peer reviewed, 2020-01-31)Background: The goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient and subclinical TB, recently defined by key stakeholders as “asymptomatic, early pre-clinical ... -
Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR)
Serigstad, Sondre; Ritz, Christian; Faurholt-Jepsen, Daniel; Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Kommedal, Øyvind; Bjørneklett, Rune Oskar; Heggelund, Lars; Clark, Tristan W.; van Werkhoven, Cornelis H.; Knoop, Siri Tandberg; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2022)Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ... -
Improving Assignments for Therapeutic and Prophylactic Treatment Within TB Households. A Potential for Immuno-Diagnosis?
Sivakumaran, Dhanasekaran; Jenum, Synne; Ritz, Christian; Vaz, Mario; Doherty, Timothy Mark; Grewal, Harleen (Journal article; Peer reviewed, 2022-03-17)Delays in diagnosis and treatment of pulmonary tuberculosis (TB) can lead to more severe disease and increased transmission. Contact investigation among household contacts (HHCs) of TB patients is crucial to ensure optimal ... -
Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children
Gjøen, John Espen; Jenum, Synne; Sivakumaran, Dhanasekaran; Mukherjee, Aparna; MacAden, Ragini; Kabra, Sushil K.; Lodha, Rakesh; Ottenhoff, Tom H.M.; Haks, Marielle C.; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2017-07-19)Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We ... -
Prevalence of Mycobacterium tuberculosis infection as measured by the QuantiFERON-TB Gold assay and ESAT-6 free IGRA among adolescents in Mwanza, Tanzania
Jeremiah, Kidola; Lyimo, Eric; Ritz, Christian; PrayGod, George; Rutkowski, Kathryn Tucker; Korsholm, Karen Smith; Ruhwald, Morten; Tait, Dereck; Grewal, Harleen; Faurholt-Jepsen, Daniel (Journal article; Peer reviewed, 2021)Background The prevalence of latent tuberculosis infection (LTBI) is vastly higher than that of tuberculosis (TB) disease and this enormous reservoir of individuals with LTBI impacts the global TB control strategy. ... -
Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield
Serigstad, Sondre; Grewal, Harleen; Ebbesen, Marit Helen; Kommedal, Øyvind; Heggelund, Lars; van Werkhoven, Werkhoven; Faurholt-Jepsen, Daniel; Clark, T.W.; Ritz, Christian; Ulvestad, Elling; Bjørneklett, Rune Oskar; Knoop, Siri Tandberg; Ravn, P.; Markussen, Dagfinn Lunde (Journal article; Peer reviewed, 2022)Lack of rapid and comprehensive microbiological diagnosis in patients with community acquired pneumonia (CAP) hampers appropriate antimicrobial therapy. This study evaluates the real-world performance of the BioFire FilmArray ...