• Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy 

      Kleeman, Sam O.; Thakir, Tuba Mansoor; Demestichas, Breanna; Mourikis, Nicholas; Loiero, Dominik; Ferrer, Miriam; Bankier, Sean; Riazat-Kesh, Yosef J.R.A.; Lee, Hassal; Chantzichristos, Dimitrios; Regan, Claire; Preall, Jonathan; Sinha, Sarthak; Rosin, Nicole; Yipp, Bryan; de Almeida, Luiz G.N.; Biernaskie, Jeff; Dufour, Antoine; Tober-Lau, Pinkus; Ruusalepp, Arno; Bjorkegren, Johan L.M.; Ralser, Markus; Kurth, Florian; Demichev, Vadim; Heywood, Todd; Gao, Qing; Johannsson, Gudmundur; Koelzer, Viktor H.; Walker, Brian R.; Meyer, Hannah V.; Janowitz, Tobias (Journal article; Peer reviewed, 2023)
      Cystatin C (CyC), a secreted cysteine protease inhibitor, has unclear biological functions. Many patients exhibit elevated plasma CyC levels, particularly during glucocorticoid (GC) treatment. This study links GCs with ...
    • Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease 

      Crawford, Andrew A.; Bankier, Sean; Altmaier, Elisabeth; Barnes, Catriona L. K.; Clark, David W.; Ermel, Raili; Friedrich, Nele; van der Harst, Pim; Joshi, Peter K.; Karhunen, Ville; Lahti, Jari; Mahajan, Anubha; Mangino, Massimo; Nethander, Maria; Neumann, Alexander; Pietzner, Maik; Sukhavasi, Katyayani; Wang, Carol A.; Bakker, Stephan J. L.; Bjorkegren, Johan L. M.; Campbell, Harry; Eriksson, Johan G.; Gieger, Christian; Hayward, Caroline; Jarvelin, Marjo-Riitta; McLachlan, Stela; Morris, Andrew P.; Ohlsson, Claes; Pennell, Craig E.; Price, Jackie; Rudan, Igor; Ruusalepp, Arno; Spector, Tim; Tiemeier, Henning; Völzke, Henry; Wilson, James F.; Michoel, Tom Luk Robert; Timpson, Nicolas J.; Smith, George Davey; Walker, Brian R. (Journal article; Peer reviewed, 2021)
      The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning ...