Browsing Bergen Open Research Archive by Author "Rye, Kristin Paulsen"

Now showing items 1-7 of 7

    • CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors 

      Brenner, Annette; Reikvam, Håkon; Rye, Kristin Paulsen; Hagen, Karen Marie; Lavecchia, Antonio; Bruserud, Øystein (Peer reviewed; Journal article, 2017-03-11)
      Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. ...

    • Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome 

      Hanevik, Kurt; Kristoffersen, Einar; Mørch, Kristine; Rye, Kristin Paulsen; Sørnes, Steinar; Svärd, Staffan; Bruserud, Øystein; Langeland, Nina (Peer reviewed; Journal article, 2017-01-28)
      Background: The role of pathogen specific cellular immune responses against the eliciting pathogen in development of post-infectious chronic fatigue syndrome (PI-CFS) is not known and such studies are difficult to perform. ...

    • GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2 

      Lellahi, Seyed Mohammad; Azeem, Waqas; Hua, Yaping; Gabriel, Benjamin; Rye, Kristin Paulsen; Reikvam, Håkon; Kalland, Karl Henning (Journal article; Peer reviewed, 2023-01-12)
      Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy. Use of cDCs ...

    • Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibition 

      Brattås, Marte Karen; Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne; Reikvam, Håkon (Journal article; Peer reviewed, 2022)
      Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a dismal prognosis. The cytoplasmic spleen tyrosine kinase (SYK) is highly expressed by hematopoietic cells and has emerged as a potential therapeutic ...

    • NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition 

      Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne; Reikvam, Håkon (Journal article; Peer reviewed, 2022)
      The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ...

    • The systemic profile of soluble immune mediators in patients with myelodysplastic syndromes 

      Kittang, Astrid Marta Olsnes; Sand, Kristoffer; Brenner, Annette; Rye, Kristin Paulsen; Bruserud, Øystein (Peer reviewed; Journal article, 2016-07-05)
      Introduction: Myelodysplastic syndromes (MDS) are characterized by bone marrow failure due to disturbed bone marrow maturation. MDS is associated with increased risk of transformation to acute myeloid leukemia (AML) and ...

    • Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity 

      Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez; Aasebø, Elise; Berven, Frode Steingrimsen; Selheim, Frode; Brenner, Annette; Rye, Kristin Paulsen; Hagen, Marie; Reikvam, Håkon; Mc Cormack, Emmet; Bruserud, Øystein; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)
      Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a ...