Blar i Bergen Open Research Archive på forfatter "Søland, Tine Merete"
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Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics
Mazagão Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Costea, Daniela Elena; Søland, Tine Merete; Galtung, Hilde (Journal article; Peer reviewed, 2020-09-04)Extracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers for diagnosis, monitoring, ... -
A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer
Bjerkli, Inger-Heidi; Hadler-Olsen, Elin Synnøve; Nginamau, Elisabeth Sivy; Laurvik, Helene; Søland, Tine Merete; Costea, Daniela Elena; Uhlin-Hansen, Lars; Steigen, Sonja Eriksson (Journal article; Peer reviewed, 2020-06-30)We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the ... -
Combined loss of expression of involucrin and cytokeratin 13 is associated with poor prognosis in squamous cell carcinoma of mobile tongue
Pandey, Sushma; Søland, Tine Merete; Bjerkli, Inger-Heidi; Sand, Lars Peter; Petersen, Fernanda Cristina; Costea, Daniela Elena; Senguven, Burcu; Sapkota, Dipak (Journal article; Peer reviewed, 2021)Background This study aimed to evaluate the prognostic significance of expression levels of involucrin (IVL), cytokeratin (CK)-10 and -13 at different intratumor sites (tumor center and invading area) of oral tongue ... -
Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography
Guerreiro, Eduarda; Vestad, Beate; Steffensen, Lilly Alice; Aass, Hans Christian Dalsbotten; Saeed, Muhammad; Øvstebø, Reidun; Costea, Daniela Elena; Galtung, Hilde; Søland, Tine Merete (Peer reviewed; Journal article, 2018-09-27)Extracellular vesicles (EVs) are a heterogeneous population of biological particles released by cells. They represent an attractive source of potential biomarkers for early detection of diseases such as cancer. However, ... -
Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?
Steigen, Sonja E; Søland, Tine Merete; Nginamau, Elisabeth Sivy; Laurvik, Helene; Costea, Daniela-Elena; Johannessen, Anne Christine; Jebsen, Peter Wilhelm; Bjerkli, Inger-Heidi; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Peer reviewed; Journal article, 2020)Background: Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring ... -
Investigation of Cross-Reactivity of Anti-Ephrin-B2 Antibody to Other Ephrin-B Members in an Immunohistochemical Study in a Cohort of Oral Squamous Cell Carcinoma
Sapkota, Dipak; Vallenari, Evan Michael; Tamatam, Dhanalakshmi; Schreurs, Olaf Joseph Franciscus; Pandey, Sushma; Søland, Tine Merete; Costea, Daniela Elena; Tokozlu, Burcu; aasheim, Hans-Christian (Journal article, 2022)Ephrin-B1,-B2 and -B3 proteins share a high degree of sequence similarity. Investigation of these proteins as putative prognostic markers in human cancers including oral squamous cell carcinoma (OSCC) has been limited by ... -
Knowledge, opinions, and practices related to oral cancer prevention and oral mucosal examination among dentists in Moldova, Belarus and Armenia: a multi-country cross-sectional study
Golburean, Olga; Hagen, Maria Helene; Uncuta, Diana; Tighineanu, Marcela; Manrikyan, Gayane; Vardanian, Izabella; Andresen, Christoffer; Singh, Bhavdeep; Porosencova, Tatiana; Ivasiuc, Irina; Cheptanaru, Olga; Markaryan, Marina; Shakavets, Natalia; Sapkota, Dipak; Søland, Tine Merete; Costea, Daniela Elena; Özkaya, Ferda (Journal article; Peer reviewed, 2021)Introduction Moldova, Belarus, and Armenia are post-Soviet countries with a high rate of heavy smokers and a relatively high age-standardized incidence of oral cancer. However, to our knowledge, there is lack of available ... -
Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report
Bjerkli, Inger-Heidi; Laurvik, Helene; Nginamau, Elisabeth Sivy; Søland, Tine Merete; Costea, Daniela Elena; Hov, Håkon; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve; Steigen, Sonja Eriksson (Journal article; Peer reviewed, 2020)Background The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and ...