Browsing Bergen Open Research Archive by Author "Søreide, Kjetil"
Now showing items 1-20 of 73
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Anastomotic leak after surgery for colon cancer and effect on long‐term survival
Stormark, Kjartan; Krarup, Peter-Martin; Sjövall, Annika; Søreide, Kjetil; Kvaløy, Jan Terje; Nordholm-Carstensen, Andreas; Nedrebø, Bjørn Steinar Olden; Kørner, Hartwig (Journal article; Peer reviewed, 2020)Aim An anastomotic leak after surgery for colon cancer is a recognized complication but how it may adversely affect long‐term survival is less clear because data are scarce. The aim of the study was to investigate the ... -
Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis
Søreide, Kjetil; Watson, Martin M; Lea, Dordi; Nordgård, Oddmund; Søreide, Jon Arne; Hagland, Hanne R (Peer reviewed; Journal article, 2016-06-29)Background: More accurate predictive and prognostic biomarkers for patients with colorectal cancer (CRC) primaries or colorectal liver metastasis (CLM) are needed. Outside clinical trials, the translational integration of ... -
Assessment of retention force and bone apposition in two differently coated femoral stems after 6 months of loading in a goat model
Harboe, Knut; Gjerdet, Nils Roar; Sudmann, Einar; Indrekvam, Kari; Søreide, Kjetil (Peer reviewed; Journal article, 2014-08-16)Background: Since the introduction of uncemented hip implants, there has been a search for the best surface coating to enhance bone apposition in order to improve retention. The surface coating of the different stems varies ... -
Benchmarking of aggregated length of stay after open and laparoscopic surgery for cancers of the digestive system
Lassen, Kristoffer; Nymo, Linn Såve; Olsen, Frank; Søreide, Kjetil (Peer reviewed; Journal article, 2018-08-01)Background: Length of hospital stay (LOS) may serve as a surrogate measure of healthcare quality and resource use, particularly when transfers of care and readmissions are accounted for. This study aimed to benchmark true ... -
The biology of aging and cancer: A brief overview of shared and divergent molecular hallmarks
Aunan, Jan Rune; Cho, William C; Søreide, Kjetil (Peer reviewed; Journal article, 2017-10)Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development. Due to advances in health care, hygiene control and food availability, life expectancy is ... -
Can bone apposition predict the retention force of a femoral stem? An experimental weight-bearing hip-implant model in goats
Harboe, Knut; Ellingsen, Christian Lycke; Sudmann, Einar; Gjerdet, Nils Roar; Søreide, Kjetil; Indrekvam, Kari (Peer reviewed; Journal article, 2015-04-28)Background: The increasing incidence of prosthesis revision surgery in the Western world has led to an increased focus on the capacity for stem removal. We previously reported on a femoral stem implanted in goats with an ... -
Cancer epigenetics in solid organ tumours: A primer for surgical oncologists
Drake, Thomas M.; Søreide, Kjetil (Peer reviewed; Journal article, 2019-05)Cancer is initiated through both genetic and epigenetic alterations. The end-effect of such changes to the DNA machinery is a set of uncontrolled mechanisms of cell division, invasion and, eventually, metastasis. Epigenetic ... -
Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways
Søreide, Kjetil; Hagland, Hanne (Peer reviewed; Journal article, 2014-03-12)The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal ... -
Centralizing a national pancreatoduodenectomy service: striking the right balance
Nymo, Linn Såve; Kleive, Dyre; Waardal, Kim; Bringeland, Erling Audun; Søreide, Jon Arne; Labori, Knut Jørgen; Mortensen, Kim Erlend; Søreide, Kjetil; Lassen, Kristoffer (Journal article; Peer reviewed, 2020)Background Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher-volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus ... -
Clinical patterns of presentation and attenuated inflammatory response in octo- and nonagenarians with perforated gastroduodenal ulcers
Søreide, Kjetil; Thorsen, Kenneth; Søreide, Jon Arne (Peer reviewed; Journal article, 2016-08)Background. Perforated gastrodudenal ulcer (PGDU) is an operative emergency with high mortality rates. The growing elderly populationincreasingly presents with need for geriatric acute operative care. Current knowledge of ... -
Collecting core data in severely injured patients using a consensus trauma template: an international multicentre study
Ringdal, Kjetil Gorseth; Lossius, Hans Morten; Jones, Mary J.; Lauritsen, Jens M.; Coats, Timothy J.; Palmer, Cameron S.; Lefering, Rolf; Bartolomeo, Stefano Di; Dries, David J.; Søreide, Kjetil (Peer reviewed; Journal article, 2011-10-12)Introduction: No worldwide, standardised definitions exist for documenting, reporting and comparing data from severely injured trauma patients. This study evaluated the feasibility of collecting the data variables of the ... -
Comparison of CpG Island Methylator Phenotype (CIMP) Frequency in Colon Cancer Using Different Probe- and Gene-Specific Scoring Alternatives on Recommended Multi-Gene Panels
Berg, Marianne; Hagland, Hanne; Søreide, Kjetil (Peer reviewed; Journal article, 2014-01-21)Background: In colorectal cancer a distinct subgroup of tumours demonstrate the CpG island methylator phenotype (CIMP). However, a consensus of how to score CIMP is not reached, and variation in definition may influence ... -
Comparison of Performance Score for Female and Male Residents in General Surgery Doing Supervised Real-Life Laparoscopic Appendectomy: Is There a Norse Shield-Maiden Effect?
Skjold-Ødegaard, Benedicte; Ersdal, Hege Langli; Assmus, Jörg; Søreide, Kjetil (Journal article; Peer reviewed, 2021)Background Gender bias may represent a threat to resident assessment during surgical training, and there have been concerns that women might be disadvantaged. There is a lack of studies investigating gender differences ... -
Deciphering the inflection points to achieve proficiency for each procedure step during training in laparoscopic appendicectomy
Skjold-Ødegaard, B.; Hamid, S.; Lindeman, Robbert-Jan; Ersdal, H.L.; Søreide, Kjetil (Journal article; Peer reviewed, 2021)Background Laparoscopic appendicectomy is a common procedure early in surgical training. A minimum number is usually required for certification in general surgery. However, data on proficiency are scarce. This study aimed ... -
Determining universal processes related to best outcome in emergency abdominal surgery: A multicentre, international, prospective cohort study
Bhangu, Aneel; Fitzgerald, J. Edward; Fergusson, Stuart; Khatri, Chetan; Holmer, Hampus; Søreide, Kjetil; Harrison, Ewen M. (Peer reviewed; Journal article, 2014-10-29)Introduction: Emergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, ... -
Development and clinical implementation of a structured, simulation-based training programme in laparoscopic appendectomy: Description, validation and evaluation
Skjold-Ødegaard, Benedicte; Ersdal, Hege Langli; Assmus, Jörg; Nedrebø, Bjørn Steinar Olden; Sjo, Ole; Søreide, Kjetil (Journal article; Peer reviewed, 2021)Background: Laparoscopic appendectomy is a common procedure in general surgery but is likely underused in structured and real-life teaching. This study describes the development, validation and evaluation of implementing ... -
Digital Image Analysis of the Proliferation Markers Ki67 and Phosphohistone H3 in Gastroenteropancreatic Neuroendocrine Neoplasms: Accuracy of Grading Compared with Routine Manual Hot Spot Evaluation of the Ki67 Index
Lea, Dordi; Gudlaugsson, Einar G.; Skaland, Ivar; Lillesand, Melinda; Søreide, Kjetil; Søreide, Jon A. (Journal article; Peer reviewed, 2021)Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare epithelial neoplasms. Grading is based on mitotic activity or the percentage of Ki67-positive cells in a hot spot. Routine methods have poor intraobserver ... -
Editorial: facts, figures and the future
Søreide, Kjetil (Peer reviewed; Journal article, 2015-01-09) -
Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis
Rushfeldt, Christian; Agledahl, Uwe; Sveinbjørnsson, Baldur; Søreide, Kjetil; Wilsgaard, Tom (Peer reviewed; Journal article, 2016-11)Background: Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed ... -
Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots
Watson, Martin M; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2019-12)INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed ...