Browsing Bergen Open Research Archive by Author "Søreide, Kjetil"
Now showing items 1-20 of 55
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Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis
Søreide, Kjetil; Watson, Martin M; Lea, Dordi; Nordgård, Oddmund; Søreide, Jon Arne; Hagland, Hanne R (Peer reviewed; Journal article, 2016-06-29)Background: More accurate predictive and prognostic biomarkers for patients with colorectal cancer (CRC) primaries or colorectal liver metastasis (CLM) are needed. Outside clinical trials, the translational integration of ... -
Assessment of retention force and bone apposition in two differently coated femoral stems after 6 months of loading in a goat model
Harboe, Knut; Gjerdet, Nils Roar; Sudmann, Einar; Indrekvam, Kari; Søreide, Kjetil (Peer reviewed; Journal article, 2014-08-16)Background: Since the introduction of uncemented hip implants, there has been a search for the best surface coating to enhance bone apposition in order to improve retention. The surface coating of the different stems varies ... -
Benchmarking of aggregated length of stay after open and laparoscopic surgery for cancers of the digestive system
Lassen, Kristoffer; Nymo, Linn Såve; Olsen, Frank; Søreide, Kjetil (Peer reviewed; Journal article, 2018-08-01)Background: Length of hospital stay (LOS) may serve as a surrogate measure of healthcare quality and resource use, particularly when transfers of care and readmissions are accounted for. This study aimed to benchmark true ... -
The biology of aging and cancer: A brief overview of shared and divergent molecular hallmarks
Aunan, Jan Rune; Cho, William C; Søreide, Kjetil (Peer reviewed; Journal article, 2017-10)Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development. Due to advances in health care, hygiene control and food availability, life expectancy is ... -
Can bone apposition predict the retention force of a femoral stem? An experimental weight-bearing hip-implant model in goats
Harboe, Knut; Ellingsen, Christian Lycke; Sudmann, Einar; Gjerdet, Nils Roar; Søreide, Kjetil; Indrekvam, Kari (Peer reviewed; Journal article, 2015-04-28)Background: The increasing incidence of prosthesis revision surgery in the Western world has led to an increased focus on the capacity for stem removal. We previously reported on a femoral stem implanted in goats with an ... -
Cancer epigenetics in solid organ tumours: A primer for surgical oncologists
Drake, Thomas M.; Søreide, Kjetil (Peer reviewed; Journal article, 2019-05)Cancer is initiated through both genetic and epigenetic alterations. The end-effect of such changes to the DNA machinery is a set of uncontrolled mechanisms of cell division, invasion and, eventually, metastasis. Epigenetic ... -
Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways
Søreide, Kjetil; Hagland, Hanne (Peer reviewed; Journal article, 2014-03-12)The interconnectivity between diet, gut microbiota and cell molecular responses is well known; however, only recently has technology allowed the identification of strains of microorganisms harbored in the gastrointestinal ... -
Clinical patterns of presentation and attenuated inflammatory response in octo- and nonagenarians with perforated gastroduodenal ulcers
Søreide, Kjetil; Thorsen, Kenneth; Søreide, Jon Arne (Peer reviewed; Journal article, 2016-08)Background. Perforated gastrodudenal ulcer (PGDU) is an operative emergency with high mortality rates. The growing elderly populationincreasingly presents with need for geriatric acute operative care. Current knowledge of ... -
Collecting core data in severely injured patients using a consensus trauma template: an international multicentre study
Ringdal, Kjetil Gorseth; Lossius, Hans Morten; Jones, Mary J.; Lauritsen, Jens M.; Coats, Timothy J.; Palmer, Cameron S.; Lefering, Rolf; Bartolomeo, Stefano Di; Dries, David J.; Søreide, Kjetil (Peer reviewed; Journal article, 2011-10-12)Introduction: No worldwide, standardised definitions exist for documenting, reporting and comparing data from severely injured trauma patients. This study evaluated the feasibility of collecting the data variables of the ... -
Comparison of CpG Island Methylator Phenotype (CIMP) Frequency in Colon Cancer Using Different Probe- and Gene-Specific Scoring Alternatives on Recommended Multi-Gene Panels
Berg, Marianne; Hagland, Hanne; Søreide, Kjetil (Peer reviewed; Journal article, 2014-01-21)Background: In colorectal cancer a distinct subgroup of tumours demonstrate the CpG island methylator phenotype (CIMP). However, a consensus of how to score CIMP is not reached, and variation in definition may influence ... -
Determining universal processes related to best outcome in emergency abdominal surgery: A multicentre, international, prospective cohort study
Bhangu, Aneel; Fitzgerald, J. Edward; Fergusson, Stuart; Khatri, Chetan; Holmer, Hampus; Søreide, Kjetil; Harrison, Ewen M. (Peer reviewed; Journal article, 2014-10-29)Introduction: Emergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, ... -
Editorial: facts, figures and the future
Søreide, Kjetil (Peer reviewed; Journal article, 2015-01-09) -
Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis
Rushfeldt, Christian; Agledahl, Uwe; Sveinbjørnsson, Baldur; Søreide, Kjetil; Wilsgaard, Tom (Peer reviewed; Journal article, 2016-11)Background: Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed ... -
Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots
Watson, Martin M; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2019-12)INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed ... -
Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?
Watson, Martin M; Lea, Dordi; Rewcastle, Emma; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2016-07)Microsatellite instability (MSI) is associated with better prognosis in colorectal cancer (CRC). Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a less-understood form of MSI. Here, we aim to ... -
Emergency resuscitative thoracotomy performed in European civilian trauma patients with blunt or penetrating injuries: a systematic review
Narvestad, Jon; Meskinfamfard, M.; Søreide, Kjetil (Peer reviewed; Journal article, 2015)Purpose: Emergency resuscitative thoracotomy (ERT) is a lifesaving procedure in selected patients. Indications are still being debated, but outcome in blunt trauma is believed to be poor. Recent reports from European ... -
Emergency surgery in the elderly: the balance between function, frailty, fatality and futility
Søreide, Kjetil; Desserud, Kari F. (Peer reviewed; Journal article, 2015-02-03)Becoming old is considered a privilege and results from the socioeconomic progress and improvements in health care systems worldwide. However, morbidity and mortality increases with age, and even more so in acute onset ... -
Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using current coding criteria
Sandvik, Oddvar Mathias; Søreide, Kjetil; Gudlaugsson, Einar; Kvaløy, Jan Terje; Søreide, Jon Arne (Peer reviewed; Journal article, 2016-02)Background: The lack of uniform criteria for coding of gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) has hampered previous epidemiological studies. The epidemiology of GEP-NEN was investigated in this study ... -
Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
Berg, Kaja Christine Graue; Sveen, Anita; Høland, Maren; Alagaratnam, Sharmini; Rasmussen, Marianne Berg; Danielsen, Stine Aske; Nesbakken, Arild; Søreide, Kjetil; Lothe, Ragnhild A (Peer reviewed; Journal article, 2019-07-15)About 80% of colorectal cancers (CRCs) have chromosomal instability, which is an integral part of aggressive malignancy development, but the importance of specific copy number aberrations (CNAs) in modulating gene expression, ... -
Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer
Berg, Marianne; Søreide, Kjetil (Peer reviewed; Journal article, 2011-12-16)Colorectal cancer is a major health burden, and a leading cause of cancer-related deaths in industrialized countries. The steady improvements in surgery and chemotherapy have improved survival, but the ability to identify ...