Blar i Bergen Open Research Archive på forfatter "Sørlie, Therese"
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Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers
Fougner, Christian; Bergholtz, Helga; Kuiper, Raoul; Norum, Jens Henrik; Sørlie, Therese (Peer reviewed; Journal article, 2019-07-31)Background Claudin-low breast cancer is a molecular subtype associated with poor prognosis and without targeted treatment options. The claudin-low subtype is defined by certain biological characteristics, some of which may ... -
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Tekpli, Xavier; Lien, Tonje Gulbrandsen; Røssevold, Andreas Hagen; Nebdal, Daniel J.H.; Borgen, Elin; Ohnstad, Hege Oma; Kyte, Jon A; Vallon-Christersson, Johan; Fongaard, Marie; Due, Eldri Undlien; Svartdal, Lisa Gregusson; Sveli, My Anh Tu; Garred, Øystein; Frigessi Di Rattalma, Arnoldo; Sahlberg, Kristine Kleivi; Sørlie, Therese; Russnes, Hege Elisabeth Giercksky; Naume, Bjørn; Kristensen, Vessela N. (Peer reviewed; Journal article, 2019)How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels ... -
A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue
Bergholtz, Helga; Lien, Tonje Gulbrandsen; Ursin, Giske; Holmen, Marit Muri; Helland, Åslaug; Sørlie, Therese; Haakensen, Vilde Drageset (Peer reviewed; Journal article, 2019-01-06)High mammographic density (MD) is associated with a 4–6 times increase in breast cancer risk. For post-menopausal women,MD often decreases over time, but little is known about the underlying biological mechanisms. MD ...