Blar i Bergen Open Research Archive på forfatter "Sakkestad, Sunniva Todnem"
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Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection
Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan; Gullaksen, Stein-Erik; Skavland, Jørn; Chauhan, Sudhir Kumar; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2023)Enterotoxigenic Escherichia coli (ETEC) is an important cause of children's and travelers’ diarrhea, with no licensed vaccine. This study aimed to explore the role of cellular immunity in protection against human ETEC ... -
Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Kleppa, Elisabeth; Lillebø, Kristine; Sævik, Marianne; Søyland, Hanne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen M.; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-06-22)Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Rykkje Heien, Astrid; Gjerde Tellevik, Marit; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
Persistent Fever and Positive PCR 90 Days Post-SARS-CoV-2 Infection in a Rituximab-Treated Patient: A Case of Late Antiviral Treatment
Ertesvåg, Nina Urke; Sakkestad, Sunniva Todnem; Zhou, Fan; Hoff, Ingrid; Kristiansen, Trygve; Jonassen, Trygve Müller; Follesø, Elisabeth; Brokstad, Karl Albert; Dyrhovden, Ruben; Mohn, Kristin Greve-Isdahl (Journal article; Peer reviewed, 2022)Background: Persistent fever after SARS-CoV-2 infection in rituximab-treated patients has been reported. Due to reduced sensitivity in conventional sampling methods and unspecific symptoms in these patients, distinguishing ... -
Proliferation of enterotoxigenic Escherichia coli strain TW11681 in stools of experimentally infected human volunteers
Vedøy, Oda Barth; Hanevik, Kurt; Sakkestad, Sunniva Todnem; Sommerfelt, Halvor; Steinsland, Hans (Peer reviewed; Journal article, 2018-10-16)Background: As part of the efort to develop an enterotoxigenic Escherichia coli (ETEC) human challenge model for testing new heat-stable toxin (ST)-based vaccine candidates, a controlled human infection model study based ... -
Reduced Plasma Guanylin Levels Following Enterotoxigenic Escherichia coli-Induced Diarrhea
Brønstad, Ingeborg; Volkmann, Hilde Løland Von; Sakkestad, Sunniva Todnem; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2023)The intestinal peptide hormones guanylin (GN) and uroguanylin (UGN) interact with the epithelial cell receptor guanylate cyclase C to regulate fluid homeostasis. Some enterotoxigenic Escherichia coli (ETEC) produce heat-stable ... -
Strong Association between Diarrhea and Concentration of Enterotoxigenic Escherichia coli Strain TW10722 in Stools of Experimentally Infected Volunteers
Vedøy, Oda Barth; Steinsland, Hans; Sakkestad, Sunniva Todnem; Sommerfelt, Halvor; Hanevik, Kurt (Journal article; Peer reviewed, 2023)Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal illness in children and travelers in low- and middle-income countries. When volunteers are infected with ETEC strains, as part of experimental ...