Browsing Bergen Open Research Archive by Author "Scherer, Andreas"
Now showing items 1-8 of 8
-
AGAP2-AS1 as a prognostic biomarker in low-risk clear cell renal cell carcinoma patients with progressing disease
Strauss, Philipp; Marti, Hans-Peter; Furriol, Jessica; Nakken, Sigrid; Vidar, Beisvåg; Eikrem, Øystein Solberg; Beisland, Christian; Flatberg, Arnar; Bostad, Leif; Scherer, Andreas; Eleni, Skandalou (Journal article; Peer reviewed, 2021)Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and one of the most common cancers. While survival for localized ccRCC is good, the survival of metastatic disease is not, and ... -
AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction
Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ... -
Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis
Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter (Peer reviewed; Journal article, 2017)Clear cell renal cell carcinoma (ccRCC) represents the most common type of kidney cancer with high mortality in its advanced stages. Our study aim was to explore the correlation between tumor epithelial-to-mesenchymal ... -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2018-03-10)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy
Rivedal, Mariell Lossius; Mikkelsen, Håvard; Marti, Hans Peter; Liu, Lili; Kiryluk, Krzysztof; Knoop, Thomas; Bjørneklett, Rune Oskar; Haaskjold, Yngvar Lunde; Furriol Palmer, Jessica; Leh, Sabine; Paunas, Flavia Teodora Ioana; Babickova, Janka; Scherer, Andreas; Serre, Camille Julia; Eikrem, Øystein Solberg; Strauss, Philipp (Journal article; Peer reviewed, 2024)Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between ... -
A multiomics disease progression signature of low-risk ccRCC
Strauss, Philipp; Rivedal, Mariell; Scherer, Andreas; Eikrem, Øystein Solberg; Nakken, Sigrid; Beisland, Christian; Bostad, Leif; Flatberg, Arnar; Skandalou, Eleni; Beisvag, Vidar; Furriol, Jessica; Marti, Hans Peter (Journal article; Peer reviewed, 2022)Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
Eikrem, Øystein Solberg; Beisland, Christian; Hjelle, Karin Margrethe; Flatberg, Arnar; Scherer, Andreas; Landolt, Lea Zoe; Skogstrand, Trude; Leh, Sabine Maria; Beisvag, Vidar; Marti, Hans-Peter (Peer reviewed; Journal article, 2016-02-22)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ... -
Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
Nordbø, Ole Petter; Landolt, Lea Zoe; Eikrem, Øystein Solberg; Scherer, Andreas; Leh, Sabine; Furriol, Jessica; Apeland, Terje; Mydel, Piotr Mateusz; Marti, Hans Peter (Journal article; Peer reviewed, 2023)Hypertensive nephrosclerosis (HN) and Type 2 diabetic nephropathy (T2DN) are the leading causes of chronic kidney disease (CKD). To explore shared pathogenetic mechanisms, we analyzed transcriptomes of kidney biopsies from ...