Browsing Bergen Open Research Archive by Author "Schjøtt, Jan"
Now showing items 1-20 of 22
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A Blended Learning Course Design in Clinical Pharmacology for Post-graduate Dental Students
Rosenbaum, Paul-Erik Lillholm; Mikalsen, Øyvind; Lygre, Henning; Solheim, Einar; Schjøtt, Jan (Peer reviewed; Journal article, 2012)Postgraduate courses in clinical pharmacology are important for dentists to be updated on drug therapy and information related to their clinical practice, as well as knowledge of relevant adverse effects and interactions. ... -
Cross-reactivity of the CEDIA buprenorphine assay in drugs-of-abuse screening: influence of dose and metabolites of opioids
Berg, Jon Andsnes; Schjøtt, Jan; Fossan, Kjell Ove; Riedel, Bettina (Peer reviewed; Journal article, 2015-10-28)Purpose: The cloned enzyme donor immunoassay (CEDIA) for buprenorphine is applied for both urine drugs-of-abuse screening and compliance monitoring. Sensitivity, specificity, and optimal cutoff of this assay have differed ... -
Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat
Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2014-05-27)Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate ... -
Distribution of psychotropic drugs into lipoproteins
Serkland, Trond T.; Schjøtt, Jan; Berg, Jon Andsnes; Herfindal, Lars; Riedel, Bettina; Skrede, Silje (Peer reviewed; Journal article, 2019)Aim: The aim of this pilot study was to investigate whether psychotropic drugs frequently analyzed in a routine therapeutic drug monitoring laboratory bind to low-density lipoproteins/very-low-density lipoproteins (LDL/VLDL) ... -
Factors associated with time consumption when answering drug-related queries to Scandinavian drug information centres: a multi-centre study
Reppe, Linda Amundstuen; Spigset, Olav; Böttiger, Ylva; Christensen, Hanne Rolighed; Kampmann, Jens Peter; Damkier, Per; Lydersen, Stian; Schjøtt, Jan (Peer reviewed; Journal article, 2014-11)Purpose There is little research-based documentation on the services provided by drug information centres (DICs). The aim of this multi-centre study was to explore for the first time the factors associated with time ... -
A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer
Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen; Hoem, Dag; Schjøtt, Jan; Gjertsen, Bjørn Tore; Biermann, Martin; Molven, Anders; Sorbye, Halfdan; McCormack, Emmet; Postema, Michiel; Gilja, Odd Helge (Peer reviewed; Journal article, 2016-12)Background: The primary aim of our study was to evaluate the safety and potential toxicity of gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer patients. The secondary aim was to ... -
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines
Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan; Kamceva, Tina; Cros-Perrial, Emeline; Langer, Anika; de Garibay, Gorka Ruiz; Kotopoulis, Spiros; McCormack, Emmet; Riedel, Bettina (Journal article; Peer reviewed, 2020)Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We ... -
Joint medicine-information and pharmacovigilance services could improve detection and communication about drug-safety problems
Schjøtt, Jan; Bergman, Jenny Christina (Peer reviewed; Journal article, 2014-07-01)Background: RELIS is a Norwegian network of four regional medicine-information and pharmacovigilance centers where pharmacists and clinical pharmacologists provide feedback to health care professionals in spontaneous ... -
Morphine enhances doxorubicin-induced cardiotoxicity in the rat
Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2014-09)Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant. Pharmacological preconditioning mimicking ischemic preconditioning has been demonstrated with morphine and represents an acceptable clinical ... -
Myocardial injury in a 41-year-old male treated with methylphenidate: a case report
Hole, Lisa Drange; Schjøtt, Jan (Peer reviewed; Journal article, 2014-07-29)Background: Elevated cardiac troponin levels are consistent with the diagnosis of an acute coronary syndrome, but may also represent adverse drug reactions. Psychostimulating drugs raise both blood pressure and heart rate, ... -
Prevention of urinary tract infections in nursing homes: lack of evidence-based prescription?
Bergman, Jenny; Schjøtt, Jan; Blix, Hege S. (Peer reviewed; Journal article, 2011-11-01)Background: Urinary tract infections (UTIs, including upper and lower symptomatic) are the most common infections in nursing homes and prevention may reduce patient suffering, antibiotic use and resistance. The spectre of ... -
Quality assessment of structure and language elements of written responses given by seven Scandinavian drug information centres
Reppe, Linda Amundstuen; Spigset, Olav; Kampmann, Jens Peter; Damkier, Per; Christensen, Hanne Rolighed; Böttiger, Ylva; Schjøtt, Jan (Peer reviewed; Journal article, 2017-05)Purpose: The aim of this study was to identify structure and language elements affecting the quality of responses from Scandinavian drug information centres (DICs). Methods: Six different fictitious drug-related queries ... -
Questions about complementary and alternative medicine to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive pilot study
Schjøtt, Jan; Erdal, Hilde (Peer reviewed; Journal article, 2014-02-14)Background: Provision of clinically relevant information about complementary and alternative medicine (CAM) to health care professionals is not well described. The aim of the study was to assess questions about CAM to the ... -
A question–answer pair (QAP) database integrated with websites to answer complex questions submitted to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive study
Schjøtt, Jan; Reppe, Linda Amundstuen; Roland, Pål-Didrik Hoff; Westergren, Tone (Peer reviewed; Journal article, 2012-03-15)Objective To assess a question–answer pair (QAP) database integrated with websites developed for drug information centres to answer complex questions effectively. Design Descriptive study with comparison of two subsequent ... -
Quetiapine, Misuse and dependency: A case-series of questions to a Norwegian network of drug information centers
Jahnsen, Jan Anker; Widnes, Sofia Frost; Schjøtt, Jan (Journal article; Peer reviewed, 2021)Purpose: The second-generation antipsychotic quetiapine has been associated with misuse and dependency. We aimed to review questions to the Norwegian network of drug information centers concerning this potential drug safety ... -
Relationship Between Time Consumption and Quality of Responses to Drug-Related Queries: A Study From Seven Drug Information Centers in Scandinavia
Reppe, Linda Amundstuen; Lydersen, Stian; Schjøtt, Jan; Damkier, Per; Christensen, Hanne Rolighed; Kampmann, Jens Peter; Böttiger, Ylva; Spigset, Olav (Peer reviewed; Journal article, 2016-07)Purpose: The aims of this study were to assess the quality of responses produced by drug information centers (DICs) in Scandinavia, and to study the association between time consumption processing queries and the quality ... -
Rethinking rehabilitation after percutaneous coronary intervention: a protocol of a multicentre cohort study on continuity of care, health literacy, adherence and costs at all care levels (the CONCARDPCI)
Norekvål, Tone Merete; Allore, Heather G; Bendz, Bjørn; Bjorvatn, Cathrine; Borregaard, Britt; Brørs, Gunhild; Deaton, Christi; Fålun, Nina Britt; Hadjistavropoulos, Heather; Hansen, Tina Birgitte; Igland, Stig; Larsen, Alf Inge; Palm, Pernille; Pettersen, Trond Røed; Rasmussen, Trine Bernholdt; Schjøtt, Jan; Søgaard, Rikke; Valaker, Irene; Zwisler, Ann Dorthe; Rotevatn, Svein (Journal article; Peer reviewed, 2020)Introduction Percutaneous coronary intervention (PCI) aims to provide instant relief of symptoms, and improve functional capacity and prognosis in patients with coronary artery disease. Although patients may experience ... -
A retrospective comparison of inappropriate prescribing of psychotropics in three Norwegian nursing homes in 2000 and 2016 with prescribing quality indicators
Schjøtt, Jan; Assmus, Jörg (Peer reviewed; Journal article, 2019)Background: Inappropriate prescribing of psychotropics is a persistent and prevalent problem in nursing homes. The present study compared inappropriate prescribing of psychotropics in nursing homes 16 years apart with ... -
Review of Clinical Questions Submitted to Norwegian Drug Information Centres Concerning Administration and Dosage to Older Patients of Relevance to Patient-Centric Care
Schjøtt, Jan; Andreassen, Lillan Mo; Dale, Gro Helen; Stokes, Charlotte L. (Journal article; Peer reviewed, 2021)Patient-centric care entails optimising healthcare provision to patients based on their perspective and opinion. It involves appropriate treatment at a reasonable cost and a focus on patient characteristics in the ... -
A short-time model to study relevant indices of cardiotoxicity of doxorubicin in the rat
Hole, Lisa Drange; Larsen, Terje H.; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (Peer reviewed; Journal article, 2013-07)Aim: Short-time models (STM) to study the cardiotoxicity (acute or chronic) of doxorubicin in rats are of interest to assess protective interventions and pathways. STM promotes more ethical animal treatment with less stress, ...