Browsing Bergen Open Research Archive by Author "Scholz, Hanne"
Now showing items 1-5 of 5
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The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation
Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Peer reviewed; Journal article, 2019-05-08)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ... -
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
Legøy, Thomas Aga; Vethe, Heidrun; Abadpour, Shadab; Strand, Berit Løkensgard; Scholz, Hanne; Paulo, Joao A.; Ræder, Helge; Ghila, Luiza; Chera, Simona (Journal article; Peer reviewed, 2020)Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating ... -
In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism
Legøy, Thomas Aga; Mathisen, Andreas Frøslev; Salim, Zaidon; Vethe, Heidrun; Bjørlykke, Yngvild; Abadpour, Shadab; Paulo, Joao; Scholz, Hanne; Ræder, Helge; Ghila, Luiza; Chera, Simona (Journal article; Peer reviewed, 2020)Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ... -
In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
Legøy, Thomas Aga; Ghila, Luiza; Vethe, Heidrun; Abadpour, Shadab; Mathisen, Andreas; Paulo, Joao A.; Scholz, Hanne; Ræder, Helge; Chera, Simona (Peer reviewed; Journal article, 2020)Aim: The loss of insulin‐secreting β‐cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into ... -
Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells
Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Peer reviewed; Journal article, 2019)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ...