Blar i Bergen Open Research Archive på forfatter "Schubert, Ulrich"
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Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly
Votteler, Jörg; Neumann, Liane; Hahn, Sabine; Hahn, Friedrich; Rauch, Pia; Schmidt, Kerstin; Studtrucker, Nicole; Solbak, Sara Marie Øie; Fossen, Torgils; Henklein, Peter; Ott, David E.; Holland, Gudrun; Bannert, Norbert; Schubert, Ulrich (Peer reviewed; Journal article, 2011-02-16)Background: The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains. Although p6 is located within one of the most polymorphic ... -
The Host-Pathogen interaction of Human Cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains
Solbak, Sara Marie Øie; Wray, Victor; Horvli, Ole; Raae, Arnt Johan; Flydal, Marte Innselset; Henklein, Petra; Henklein, Peter; Nimtz, Manfred; Schubert, Ulrich; Fossen, Torgils (Peer reviewed; Journal article, 2011-12-20)Background: Cyclophilin A (CypA) represents a potential key molecule in future antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication. CypA interacts with the ... -
The intriguing Cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding
Solbak, Sara Marie Øie; Reksten, Tove Ragna; Wray, Victor; Bruns, Karsten; Horvli, Ole; Raae, Arnt Johan; Henklein, Petra; Henklein, Peter; Röder, Rene; Mitzner, David; Schubert, Ulrich; Fossen, Torgils (Peer reviewed; Journal article, 2010-10-04)Background: Cyclophilin A (CypA) represents a potential target for antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication, although the mechanism through which ... -
Mutation of the highly conserved ser-40 of the HIV-1 p6 gag protein to phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of gag
Hahn, Friedrich; Setz, Christian; Friedrich, Melanie; Rauch, Pia; Solbak, Sara Marie Øie; Frøystein, Nils Åge; Henklein, Petra; Votteler, Jörg; Fossen, Torgils; Schubert, Ulrich (Peer reviewed; Journal article, 2014-10-02)The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the ...