Browsing Bergen Open Research Archive by Author "Schuster, Cornelia"
Now showing items 1-6 of 6
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Clinical Efficacy and Safety of Bevacizumab Monotherapy in Patients with Metastatic Melanoma: Predictive Importance of Induced Early Hypertension
Schuster, Cornelia; Eikesdal, Hans Petter; Puntervoll, Hanne; Geisler, Jürgen; Geisler, Stephanie; Molven, Anders; Akslen, Lars A. (Peer reviewed; Journal article, 2012-06-15)Background: VEGF driven angiogenesis plays a key role in cancer progression. We determined the clinical efficacy of bevacizumab monotherapy in patients with metastatic melanoma. Methods and Findings: Thirty-five patients ... -
ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab
Forthun, Rakel Brendsdal; Hovland, Randi; Schuster, Cornelia; Puntervoll, Hanne Eknes; Brodal, Hans Petter; Namløs, Heidi Maria; Aasheim, Lars Birger; Meza, Leonardo Zepeda; Gjertsen, Bjørn Tore; Knappskog, Stian; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)Bevacizumab is included in an increasing number of clinical trials. To find biomarkers to predict and monitor treatment response, cancer and angiogenesis relevant mutations in tumour and circulating tumour DNA (ctDNA) were ... -
Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study
Schuster, Cornelia; Akslen, Lars A.; Straume, Oddbjørn (Journal article, 2016-05-11)The aim of this study was to identify potential predictive biomarkers in 35 patients with metastatic melanoma treated with anti-angiogenic bevacizumab monotherapy in a clinical phase II study. The immunohistochemical ... -
Investigation of predictive markers in patients with metastatic melanoma treated with bevacizumab
Schuster, Cornelia (Doctoral thesis, 2016-11-22)Background: The incidence of malignant melanoma is still rising among fair- skinned people worldwide, and it is among the three major cancer types in young adults in Norway. Progression free survival and overall survival ... -
Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy
Schuster, Cornelia; Akslen, Lars A.; Stokowy, Tomasz; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment ... -
Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma
Hugdahl, Emilia Signe; Bachmann, Ingeborg M.; Schuster, Cornelia; Ladstein, Rita Grude; Akslen, Lars A. (Peer reviewed; Journal article, 2019-01-14)Angiogenesis is important for the progression of cutaneous melanoma. Here, we analyzed the prognostic impact of the angiogenic factor urokinase plasminogen activator resecptor (uPAR), vascular proliferation index (VPI) and ...