Browsing Bergen Open Research Archive by Author "Sharma, Suraj"

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Accounting for NAD Concentrations in Genome-Scale Metabolic Models Captures Important Metabolic Alterations in NAD-Depleted Systems

Sauter, Roland; Sharma, Suraj; Heiland, Ines (Journal article; Peer reviewed, 2024)

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous molecule found within all cells, acting as a crucial coenzyme in numerous metabolic reactions. It plays a vital role in energy metabolism, cellular signaling, and DNA ...
Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria

Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Peer reviewed, 2022)

Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ...
Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites

Egger, Anna-Sophia; Rauch, Eva; Sharma, Suraj; Kipura, Tobias; Hotze, Madlen; Mair, Thomas; Hohenegg, Alina; Kobler, Philipp; Heiland, Ines; Kwiatkowski, Marcel (Journal article; Peer reviewed, 2024)

Objectives Histone acetylation is an important epigenetic modification that regulates various biological processes and cell homeostasis. Acetyl-CoA, a hub molecule of metabolism, is the substrate for histone acetylation, ...