Browsing Bergen Open Research Archive by Author "Simbriger, Konstanze"
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Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity
Kouloulia, Stella; Hallin, Erik Ingmar; Simbriger, Konstanze; Amorim, Ines S; Lach, Gilliard; Amvrosiadis, Theoklitos; Chalkiadaki, Kleanthi; Kampaite, Agniete; Truong, Vinh Tai; Hooshmandi, Mehdi; Jafarnejad, Seyed Mehdi; Skehel, Paul; Kursula, Petri; Khoutorsky, Arkady; Gkogkas, Christos (Peer reviewed; Journal article, 2019)The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central ...