Browsing Bergen Open Research Archive by Author "Singh, Reema"

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The Interplay Between Prostate Cancer Genomics, Metabolism, and the Epigenome: Perspectives and Future Prospects

Singh, Reema; Mills, Ian (Journal article; Peer reviewed, 2021)

Prostate cancer is a high-incidence cancer, often detected late in life. The prostate gland is an accessory gland that secretes citrate; an impaired citrate secretion reflects imbalances in the activity of enzymes in the ...
Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

Amoroso, Francesca; Glass, Kimberley; Singh, Reema; Liberal, Francisco; Steele, Rebecca E.; Maguire, Sarah; Tarapore, Rohinton; Allen, Joshua E.; Van Schaeybroeck, Sandra; Butterworth, Karl T.; Prise, Kevin; O’Sullivan, Joe M.; Jain, Suneil; Waugh, David J.; Mills, Ian (Journal article; Peer reviewed, 2021)

Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can ...