Blar i Bergen Open Research Archive på forfatter "Sivonen, Kaarina"
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Anabaenolysins, Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteria
Jokela, Jouni; Oftedal, Linn; Herfindal, Lars; Permi, Perttu; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Peer reviewed; Journal article, 2012-07-19)Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a ... -
Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes
Humisto, Anu; Jokela, Jouni; Teigen, Knut; Wahlsten, Matti; Permi, Perttu; Sivonen, Kaarina; Herfindal, Lars (Peer reviewed; Journal article, 2019-08-01)Hassallidins are cyclic glycolipopeptides produced by cyanobacteria and other prokaryotes. The hassallidin structure consists of a peptide ring of eight amino acids where a fatty acid chain, additional amino acids, and ... -
Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria
Fewer, David P.; Jokela, Jouni; Heinilä, Lassi; Aesoy, Reidun; Sivonen, Kaarina; Galica, Tomáš; Hrouzek, Pavel; Herfindal, Lars (Journal article; Peer reviewed, 2021)Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty ... -
Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells
Liu, Liwei; Herfindal, Lars; Jokela, Jouni; Shishido, Tania Keiko; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Peer reviewed; Journal article, 2014-04-03)In this study, we investigated forty cyanobacterial isolates from biofilms, gastropods, brackish water and symbiotic lichen habitats. Their aqueous and organic extracts were used to screen for apoptosis-inducing activity ... -
Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes
Oftedal, Linn Silje Wathne; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Døskeland, Stein Ove; Herfindal, Lars (Peer reviewed; Journal article, 2010-10-14)The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial ... -
NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform
Allahverdiyeva, Yagut; Aro, Eva-Mari; Bavel, Bert van; Escudero, Carlos; Funk, Christiane; Heinonen, Jarna; Herfindal, Lars; Lindblad, Peter; Makinen, Sari; Penttilä, Merja; Sivonen, Kaarina; Chauton, Matilde Skogen; Skomedal, Hanne; Skjermo, Jorunn (Journal article; Peer reviewed, 2021)NordAqua is a multidisciplinary Nordic Center of Excellence funded by NordForsk Bioeconomy program (2017–2022). The research center promotes Blue Bioeconomy and endeavours to reform the use of natural resources in a ...