Blar i Bergen Open Research Archive på forfatter "Skarstein, Kathrine"
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Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjogren's syndrome in salivary glands of non-obese diabetic mice
Gatumu, Margaret Karimi; Skarstein, Kathrine; Papandile, Adrian; Browning, Jeffrey L.; Fava, Roy A.; Bolstad, Anne Isine (Peer reviewed; Journal article, 2009-02-18)Introduction The lymphotoxin-beta receptor (LTβR) pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases such as ... -
Epidemiology of Sjögrens syndrome-from an oral perspective
Bolstad, Anne Isine; Skarstein, Kathrine (Peer reviewed; Journal article, 2016)Oral symptoms are among the most distressing manifestations for patients with Sjögren’s syndrome (SS). The feeling of dry mouth is unpleasant, and hyposalivation may contribute to difficulty in speaking, chewing and ... -
Expression of NGAL-specific cells and mRNA levels correlate with inflammation in the salivary gland, and its overexpression in the saliva, of patients with primary Sjögren’s syndrome
Aqrawi, Lara Adnan; Jensen, Janicke Cecilie Liaaen; Fromreide, Siren; Galtung, Hilde Kanli; Skarstein, Kathrine (Journal article; Peer reviewed, 2020)Salivary gland involvement is a characteristic feature of primary Sjögren’s syndrome (pSS), where tissue destruction is mediated by infiltrating immune cells, and may be accompanied by the presence of adipose tissue. ... -
Integrin a11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression
Parajuli, Himalaya; Teh, Muy-Teck; Abrahamsen, Siren; Christoffersen, Ingeborg Monge; Neppelberg, Evelyn; Lybak, Stein; Osman, Tarig Al-Hadi; Johannessen, Anne Christine; Gullberg, Donald; Skarstein, Kathrine; Costea, Daniela Elena (Peer reviewed; Journal article, 2017-04)BACKGROUND: Cancer-associated fibroblasts (CAFs) were shown to be important for tumour progression in head and neck squamous cell carcinomas (HNSCCs). Their heterogeneity and lack of specific markers is increasingly ... -
Lymphotoxin-beta Receptor blockade reduces CXCL13 in Lacrimal Glands and improves Corneal integrity in the NOD Model of Sjögren's Syndrome
Fava, Roy A.; Kennedy, Susan M.; Wood, Sheryl G.; Bolstad, Anne Isine; Bienkowska, Jadwiga; Papandile, Adrian; Kelly, John A.; Mavragani, Clio P.; Gatumu, Margaret Karimi; Skarstein, Kathrine; Browning, Jeffrey L. (Peer reviewed; Journal article, 2011-11-01)Introduction: In Sjögren’s syndrome, keratoconjunctivitis sicca (dry eye) is associated with infiltration of lacrimal glands by leukocytes and consequent losses of tear-fluid production and the integrity of the ocular ... -
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers
Aqrawi, Lara Adnan; Galtung, Hilde; Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Utheim, Tor Paaske; Chen, Xiangjun; Utheim, Øygunn Aass; Palm, Øyvind; Skarstein, Kathrine; Jensen, Janicke Liaaen (Peer reviewed; Journal article, 2019-07-31)Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca ... -
Salivary glands of primary Sjögren’s syndrome patients express factors vital for plasma cell survival
Szyszko, Ewa A.; Brokstad, Karl Albert; Øijordsbakken, Gunnvor; Jonsson, Malin Viktoria; Jonsson, Roland; Skarstein, Kathrine (Peer reviewed; Journal article, 2011-01-07)Introduction: The presence of circulating Ro/SSA and La/SSB autoantibodies has become an important marker in the classification criteria for primary Sjögren’s syndrome (pSS). Plasma cells producing these autoantibodies are ...