Blar i Bergen Open Research Archive på forfatter "Skavland, Jørn"
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0729. Interstitial changes in spleen during sepsis
Svendsen, Øyvind Sverre; Stangeland, Lodve; Elvevoll, Bjørg; Gjertsen, Bjørn Tore; Skavland, Jørn; Wiig, Helge; Tenstad, Olav; Husby, Paul (Conference object; Peer reviewed, 2014-09-26) -
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation
Reikvam, Håkon; Skavland, Jørn; Gullaksen, Stein-Erik; Hovland, Randi; Gedde-Dahl, Tobias; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2018-09-23)Chronic myeloid leukemia (CML) is a myeloproliferative disorder in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein BCR-ABL1. Allogeneic stem cell transplantation (allo-SCT) was ... -
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis
Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frédéric; Rouhee, Nazanin; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Døskeland, Stein Ove (Peer reviewed; Journal article, 2013)We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect ... -
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
Ersvær, Elisabeth; Liseth, Knut; Skavland, Jørn; Gjertsen, Bjørn Tore; Bruserud, Øystein (Peer reviewed; Journal article, 2010-07-09)Background Several observations suggest that immunological events early after chemotherapy, possibly during the period of severe treatment-induced cytopenia, are important for antileukemic immune reactivity in acute myeloid ... -
Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells
Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius; McClymont, David; Skavland, Jørn; Gavasso, Sonia; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-11)Hydrogen sulfide (H2S) is an endogenous gasotransmitter in human physiology and inflammatory disease, however, with limited knowledge of how signal transduction pathways are involved in immune cells. To examine the effects ... -
Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Thobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Mohammed Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2017-08)Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted ... -
Titrating complex mass cytometry panels
Gullaksen, Stein-Erik; Bader, Lucius; Hellesøy, Monica; Sulen, Andre; Fagerholt, Oda Helen Eck; Engen, Caroline Benedicte Nitter; Skavland, Jørn; Gjertsen, Bjørn Tore; Gavasso, Sonia (Peer reviewed; Journal article, 2019-07-13)We describe here a simple and efficient antibody titration approach for cell‐surface markers and intracellular cell signaling targets for mass cytometry. The iterative approach builds upon a well‐characterized backbone ...