Browsing Bergen Open Research Archive by Author "Skjevik, Åge Aleksander"
Now showing items 1-3 of 3
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Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone
Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut; Martinez, Aurora (Journal article; Peer reviewed, 2022)Vesicular monoamine transporter 2 (VMAT2) is responsible for packing monoamine neurotransmitters into synaptic vesicles for storage and subsequent neurotransmission. VMAT2 inhibitors are approved for symptomatic treatment ... -
Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles
Dobrovolska, Olena; Strømland, Øyvind; Handegård, Ørjan Sele; Jakubec, Martin; Govasli Larsen, Morten Andreas; Skjevik, Åge Aleksander; Frøystein, Nils Åge; Teigen, Knut; Halskau, Øyvind (Journal article; Peer reviewed, 2021)The driving forces and conformational pathways leading to amphitropic protein-membrane binding and in some cases also to protein misfolding and aggregation is the subject of intensive research. In this study, a chimeric ... -
The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes
Skjevik, Åge Aleksander; Mileni, Mauro; Baumann, Anne; Halskau, Øyvind; Teigen, Knut; Raymond C., Stevens; Martinez, Aurora (Peer reviewed; Journal article, 2014-01-09)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamine neurotransmitters, and a reduction in TH activity is associated with several neurological diseases. Human TH is regulated, among ...