Browsing Bergen Open Research Archive by Author "Skogstrand, Trude"
Now showing items 1-11 of 11
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AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction
Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ... -
The effect of stromal integrin β3-deficiency on two different tumors in mice
Reigstad, Inga; Sortland, Kristina; Skogstrand, Trude; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2016-01-12) -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2018-03-10)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction
Tveitarås, Maria Kathrine; Skogstrand, Trude; Leh, Sabine Maria; Helle, Frank; Iversen, Bjarne Magnus; Chatziantoniou, Christos; Reed, Rolf K.; Hultström, Michael (Peer reviewed; Journal article, 2015-12-16)Matrix Metalloproteinase-2 (Mmp2) is a collagenase known to be important in the development of renal fibrosis. In unilateral ureteral obstruction (UUO) the obstructed kidney (OK) develops fibrosis, while the contralateral ... -
Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats
Thowsen, Irene Matre; Karlsen, Tine Veronica; Nikpey, Elham; Haslene-Hox, Hanne; Skogstrand, Trude; Randolph, Gwendalyn J.; Zinselmeyer, Bernd H.; Tenstad, Olav; Wiig, Helge (Journal article; Peer reviewed, 2022)Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated whether there were electrolyte gradients ... -
Pharmacokinetics and pharmacodynamics of t-cell bispecifics in the tumour interstitial fluid
Eigenmann, Miro Julian; Karlsen, Tine Veronica; Wagner, Marek; Tenstad, Olav; Weinzierl, Tina; Fauti, Tanja; Grimm, Hans Peter; Skogstrand, Trude; Klein, Christian; Sam, Johannes; Umana, Pablo; Bacac, Marina; Wiig, Helge; Walz, Antje-Christine (Journal article; Peer reviewed, 2021)The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent ... -
Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats
Finne, Kenneth; Vethe, Heidrun; Skogstrand, Trude; Leh, Sabine Maria; Dahl, Tone Dolva; Tenstad, Olav; Berven, Frode S.; Reed, Rolf K.; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2014-08-16)Background It is well known that hypertension may cause glomerular damage, but the molecular mechanisms involved are still incompletely understood. Methods In the present study, we used formalin-fixed paraffin-embedded ... -
Stromal integrin α11β1 affects RM11 prostate and 4T1 breast xenograft tumors differently
Reigstad, Inga; Smeland, Hilde Ytre-Hauge; Skogstrand, Trude; Sortland, Kristina; Schmid, Caroline; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2016-03-18)Purpose It has been implied that the collagen binding integrin α11β1 plays a role in carcinogenesis. As still relatively little is known about how the stromal integrin α11β1 affects different aspects of tumor development, ... -
Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome
Becirovic-Agic, Mediha; Jönsson, Sofia; Tveitarås, Maria Kathrine; Skogstrand, Trude; Karlsen, Tine Veronica; Liden, Åsa; Leh, Sabine Maria; Ericsson, Madelene; Nilsson, Stefan K.; Reed, Rolf K.; Hultström, Michael (Peer reviewed; Journal article, 2019-05-01)The genetic background of a mouse strain determines its susceptibility to disease. C57BL/6J and Balb/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt ... -
Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development
Eikrem, Øystein Solberg; Beisland, Christian; Hjelle, Karin Margrethe; Flatberg, Arnar; Scherer, Andreas; Landolt, Lea Zoe; Skogstrand, Trude; Leh, Sabine Maria; Beisvag, Vidar; Marti, Hans-Peter (Peer reviewed; Journal article, 2016-02-22)Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, ... -
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats
Samuelsson, Anne-Maj; Bartolomaeus, Theda Ulrike Patricia; Anandakumar, Harithaa; Thowsen, Irene Matre; Nikpey, Elham; Han, Jianhua; Marko, Lajos; Finne, Kenneth; Tenstad, Olav; Eckstein, Johannes; Berndt, Nikolaus; Kühne, Titus; Kedziora, Sarah; Sultan, Ibrahim; Skogstrand, Trude; Karlsen, Tine Veronica; Nurmi, Harri; Forslund, Sofia K.; Bollano, Entela; Alitalo, Kari; Muller, Dominik N.; Wiig, Helge (Journal article; Peer reviewed, 2023)Aims: Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial ...