Blar i Bergen Open Research Archive på forfatter "Skrede, Steinar"
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Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital
Nygård, Siri Tandberg; Langeland, Nina; Flaatten, Hans; Fanebust, Rune; Haugen, Oddbjørn; Skrede, Steinar (Peer reviewed; Journal article, 2014-03-04)Background: Severe sepsis is recognized as an inflammatory response causing organ dysfunction in patients with infection. Antimicrobial therapy is the mainstay of treatment. There is an ongoing demand for local surveillance ... -
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
Jahagirdar, Sanjeevan; Morris, Lorna; Benis, Nirupama; Oppegaard, Oddvar; Svenson, Mattias; Hyldegaard, Ole; Skrede, Steinar; Norrby-Teglund, Anna; Bruun, Trond; Rath, Eivind; Nedrebø, Torbjørn; Arnell, Per; Rosen, Anders; Hedetoft, Morten; Madsen, Martin B.; Svensson, Mattias; Snäll, Johanna; Karlsson, Ylva; Nekludov, Michael; Martins dos Santos, Vitor A. P.; Saccenti, Edoardo (Journal article; Peer reviewed, 2022)Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ... -
Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study
Sriskandarajah, Sanjeevan; Bostad, Leif; Myklebust, Tor Åge; Møller, Bjørn; Skrede, Steinar; Bjørneklett, Rune (Peer reviewed; Journal article, 2017-12-18)Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives. To quantify the cancer risk associated with contemporary ... -
Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections
Gundersen, Ingunn Margareetta; Berget, Ellen; Haugland, Hans Kristian; Bruun, Trond; Almeland, Stian Kreken; Assmus, Jörg; Rath, Eivind; Norrby-Teglund, Anna; Skrede, Steinar; Mosevoll, Knut Anders (Journal article; Peer reviewed, 2022)Background Necrotizing soft tissue infections (NSTIs) are severe diseases with high morbidity and mortality. The diagnosis is challenging. Several guidelines recommend tissue biopsies as an adjunct diagnostic in routine ... -
Consistent biofilm formation by Streptococcus pyogenes emm 1 isolated from patients with necrotizing soft tissue infections
Skutlaberg, Dag Harald; Wiker, Harald Gotten; Mylvaganam, Haima; Norrby-Teglund, Anna; Skrede, Steinar (Journal article; Peer reviewed, 2022-02-18)Objectives: Biofilm formation has been demonstrated in muscle and soft tissue samples from patients with necrotizing soft tissue infection (NSTI) caused by Streptococcus pyogenes, but the clinical importance of this ... -
Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections
Katz, Sonja; Suijker, Jaco; Hardt, Christopher; Madsen, Martin Bruun; Vries, Annebeth Meij-de; Pijpe, Anouk; Skrede, Steinar; Hyldegaard, Ole; Solligård, Erik; Norrby-Teglund, Anna; Saccenti, Edoardo; Martins dos Santos, Vitor A.P. (Journal article; Peer reviewed, 2022)Introduction: Necrotizing Soft Tissue Infections (NSTI) are severe infections with high mortality affecting a heterogeneous patient population. There is a need for a clinical decision support system which predicts outcomes ... -
Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination
Tete, Sarah; Krammer, Florain; Jalloh, Sarah Larteley Lartey; Bredholt, Geir; Wood, John M.; Skrede, Steinar; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-07-28)Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, ... -
Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors
Bruun, Trond; Oppegaard, Oddvar; Hufthammer, Karl Ove; Langeland, Nina; Skrede, Steinar (Peer reviewed; Journal article, 2016)Background: Skin and soft tissue infections are common reasons for medical care. Use of broad-spectrum therapy and costs have increased. Assessment of early treatment response has been given a central role both in clinical ... -
Emergence of a Streptococcus dysgalactiae subspecies equisimilis stG62647-lineage associated with severe clinical manifestations
Oppegaard, Oddvar; Mylvaganam, Haima; Skrede, Steinar; Lindemann, Paul Christoffer; Kittang, Bård Reiakvam (Peer reviewed; Journal article, 2017-08-08)Increasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (SDSE) infections have been reported worldwide, but the evolutionary mechanisms underlying this development remain elusive. Through ... -
emm gene diversity, superantigen gene profiles and presence of SlaA among clinical isolates of group A, C and G streptococci from western Norway
Kittang, Bård Reiakvam; Skrede, Steinar; Langeland, Nina; Haanshuus, Christel Gill; Mylvaganam, Haima (Peer reviewed; Journal article, 2010-11-20)In order to investigate molecular characteristics of beta-hemolytic streptococcal isolates from western Norway, we analysed the entire emm gene sequences, obtained superantigen gene profiles and determined the prevalence ... -
Epidemiology and impact on all-cause mortality of sepsis in Norwegian hospitals: A national retrospective study
Knoop, Siri Tandberg; Skrede, Steinar; Langeland, Nina; Flaatten, Hans (Peer reviewed; Journal article, 2017-11-17)Background: Although sepsis is the leading cause of death from infection, there are few population-level epidemiological sepsis reports. The impact of sepsis-related deaths on all-cause hospital mortality is insufficiently ... -
Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward
Skrede, Steinar; Steinsland, Hans; Sommerfelt, Halvor; Aase, Audun; Brandtzaeg, Per; Langeland, Nina; Cox, Rebecca Jane; Sævik, Marianne; Wallevik, Marita; Skutlaberg, Dag Harald; Tellevik, Marit Gjerde; Sack, David A.; Nataro, James P.; Guttormsen, Anne Berit (Peer reviewed; Journal article, 2014-09-04)Background: Enterotoxigenic Escherichia coli (ETEC) is an important cause of childhood diarrhea in resource-limited regions. It is also an important cause of diarrhea in travellers to these areas. To evaluate the protective ... -
Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Kleppa, Elisabeth; Lillebø, Kristine; Sævik, Marianne; Søyland, Hanne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen M.; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-06-22)Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled ... -
Genomic epidemiology of Streptococcus dysgalactiae subsp. equisimilis strains causing invasive disease in Norway during 2018
Kaci, Alba; Jonassen, Christine M; Skrede, Steinar; Sivertsen, Audun; Steinbakk, Martin; Oppegaard, Oddvar (Journal article; Peer reviewed, 2023)Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging global pathogen, yet the epidemiology and population genetics of SDSE species have not been extensively characterized. Methods: We ... -
Improved prognosis in Norwegian patients with glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies
Sriskandarajah, Sanjeevan; Aasarød, Knut; Skrede, Steinar; Knoop, Thomas; Reisæter, Anna Varberg; Bjørneklett, Rune (Peer reviewed; Journal article, 2014-02-17)Background. Glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased mortality and a high risk of end-stage renal disease (ESRD). Here, we investigated whether the ... -
Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections
Siemens, Nikolai; Kittang, Bård Reiakvam; Chakrakodi, Bhavya; Oppegaard, Oddvar; Johansson, Linda; Bruun, Trond; Mylvaganam, Haima; Svensson, Mattias; Skrede, Steinar; Norrby-Teglund, Anna (Peer reviewed; Journal article, 2015)Streptococcus dysgalactiae subsp. equisimilis (SDSE) has emerged as an important cause of severe skin and soft tissue infections, but little is known of the pathogenic mechanisms underlying tissue pathology. Patient samples ... -
Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
Movert, Elin; Bolarin, Jaume Salgado; Valfridsson, Christine; Velarde, Jorge; Skrede, Steinar; Nekludov, Michael; Hyldegaard, Ole; Arnell, Per; Svensson, Mattias; Norrby-Teglund, Anna; Cho, Kyu Hong; Elhaik, Eran; Wessels, Michael R.; Råberg, Lars; Carlsson, Fredric (Journal article; Peer reviewed, 2023)Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes ... -
Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
Shumba, Patience; Sura, Thomas; Moll, Kirsten; Chakrakodi, Bhavya; Tölken, Lea A.; Hoßmann, Jörn; Hoff, Katharina J.; Hyldegaard, Ole; Nekludov, Michael; Svensson, Mattias; Arnell, Per; Skrede, Steinar; Norrby-Teglund, Anna; Siemens, Nikolai (Journal article; Peer reviewed, 2023)Background Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Rykkje Heien, Astrid; Gjerde Tellevik, Marit; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
Skåringsverktøy for tidlig oppdagelse av sepsis på sengepost
Karlsen, Elisabet Ethun; Rønsåsbjørg, Nora Almlid; Skrede, Steinar; Mosevoll, Knut Anders (Journal article; Peer reviewed, 2023)BAKGRUNN Sepsis er en av de vanligste årsakene til død i norske sykehus. Tilstanden er ofte oversett og behandlingen forsinket. Skåringsverktøy for å oppdage pasienter med sepsis er hyppigst undersøkt i akuttmottak, ...