• Abnormal phasic activity in saliency network, motor areas, and basal ganglia in Parkinson's disease during rhythm perception 

      Vikene, Kjetil; Skeie, Geir Olve; Specht, Karsten (Peer reviewed; Journal article, 2019)
      Behavioral studies indicate that persons with Parkinson's disease have complexity dependent problems with the discrimination of auditory rhythms. Furthermore, neuroimaging studies show that rhythm processing activates many ...
    • Adults with attention-deficit/hyperactivity disorder. A brain magnetic resonance spectroscopy study 

      Dramsdahl, Margaretha; Ersland, Lars; Plessen, Kerstin von; Haavik, Jan; Hugdahl, Kenneth; Specht, Karsten (Peer reviewed; Journal article, 2011-11-23)
      Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the ...
    • Altered resting state effective connectivity of anterior insula in depression 

      Kandilarova, Sevdalina; Stoyanov, Drozdstoy; Kostianev, Stefan; Specht, Karsten (Peer reviewed; Journal article, 2018-03-15)
      Depression has been associated with changes in both functional and effective connectivity of large scale brain networks, including the default mode network, executive network, and salience network. However, studies of ...
    • Arterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke's aphasia 

      Robson, Holly; Specht, Karsten; Beaumont, Helen; Parkes, Laura M.; Sage, Karen; Lambon Ralph, Matthew A.; Zahn, Roland (Peer reviewed; Journal article, 2017-07)
      Behavioural impairment post-stroke is a consequence of structural damage and altered functional network dynamics. Hypoperfusion of intact neural tissue is frequently observed in acute stroke, indicating reduced functional ...
    • Associations between lesion size, lesion location and aphasia in acute stroke 

      Døli, Hedda; Helland, Wenche A.; Helland, Turid; Specht, Karsten (Journal article; Peer reviewed, 2020)
      Background: The localization and organization of language has been an ongoing research interest ever since the early findings of Paul Broca. The emergence of neuroimaging the past 20 years has given us new insights on the ...
    • Children with dyslexia show cortical hyperactivation in response to increasing literacy processing demands 

      Morken, Frøydis; Helland, Turid; Hugdahl, Kenneth; Specht, Karsten (Peer reviewed; Journal article, 2014-12-22)
      This fMRI study aimed to examine how differences in literacy processing demands may affect cortical activation patterns in 11- to 12-year-old children with dyslexia as compared to children with typical reading skills. ...
    • Compensatory task-specific hypersensitivity in bilateral planum temporale and right superior temporal gyrus during auditory rhythm and omission processing in Parkinson's disease 

      Vikene, Kjetil; Skeie, Geir Olve; Specht, Karsten (Peer reviewed; Journal article, 2019)
      Persons with Parkinson’s disease have general timing deficits and have difficulties in rhythm discrimination tasks. The basal ganglia, a crucial part of Parkinson’s disease pathology, is believed to play an important role ...
    • Congenital prosopagnosia: multistage anatomical and functional deficits in face processing circuitry 

      Dinkelacker, V.; Grüter, M.; Klaver, P.; Grüter, T.; Specht, Karsten; Weis, S.; Kennerknecht, I.; Elger, C. E.; Fernandez, G. (Peer reviewed; Journal article, 2010-12-01)
      Face recognition is a primary social skill which depends on a distributed neural network. A pronounced face recognition deficit in the absence of any lesion is seen in congenital prosopagnosia. This study investigating 24 ...
    • Cortical thickness and resting‐state cardiac function across the lifespan: A cross‐sectional pooled mega‐analysis 

      Koenig, Julian; Abler, Birgit; Agartz, Ingrid; Åkerstedt, Torbjørn; Andreassen, Ole Andreas; Anthony, Mia; Bär, Karl-Jürgen; Bertsch, Katja; Brown, Rebecca C.; Brunner, Romuald; Carnevali, Luca; Critchley, Hugo D.; Cullen, Kathryn R; de Geus, Eco J C; de la Cruz, Feliberto; Dziobek, Isabel; Ferger, Marc D.; Fischer, Håkan; Flor, Herta; Gaebler, Michael; Gianaros, Peter J.; Giummarra, Melita J.; Greening, Steven G.; Guendelman, Simon; Heathers, James A. J.; Herpertz, Sabine C.; Hu, Mandy X.; Jentschke, Sebastian; Kaess, Michael; Kaufmann, Tobias; Klimes-Dougan, Bonnie; Koelsch, Stefan; Krauch, Marlene; Kumral, Deniz; Lamers, Femke; Lee, Tae‐Ho; Lekander, Mats; Lin, Feng; Lotze, Martin; Makovac, Elena; Mancini, Matteo; Mancke, Falk; Månsson, Kristoffer N. T.; Manuck, Stephen B.; Mather, Mara; Meeten, Frances; Min, Jungwon; Mueller, Bryon A.; Muench, Vera; Nees, Frauke; Nga, Lin; Nilsonne, Gustav; Ordonez Acuna, Daniela; Osnes, Berge; Ottaviani, Cristina; Penninx, Brenda W J H; Ponzio, Allison; Poudel, Govinda R.; Reinelt, Janis; Ren, Ping; Sakaki, Michiko; Schumann, Andy; Sørensen, Lin; Specht, Karsten; Straub, Joana; Tamm, Sandra; Thai, Michelle; Thayer, Julian F.; Ubani, Benjamin; van der Mee, Denise J.; van Velzen, Laura S.; Ventura‐Bort, Carlos; Villringer, Arno; Watson, David R.; Wei, Luqing; Wendt, Julia; Westlund Schreiner, Melinda; Westlye, Lars Tjelta; Weymar, Mathias; Winkelmann, Tobias; Wu, Guo‐Rong; Yoo, Hyun Joo; Quintana, Daniel (Journal article; Peer reviewed, 2020)
      Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ...
    • Current Challenges in Translational and Clinical fMRI and Future Directions 

      Specht, Karsten (Journal article; Peer reviewed, 2020)
      Translational neuroscience is an important field that brings together clinical praxis with neuroscience methods. In this review article, the focus will be on functional neuroimaging (fMRI) and its applicability in clinical ...
    • Default-mode network functional connectivity is closely related to metabolic activity 

      Passow, Susanne; Specht, Karsten; Adamsen, Tom Christian; Biermann, Martin; Brekke, Njål; Craig-Craven, Alexander Richard; Ersland, Lars; Grüner, Renate; Kleven-Madsen, Nina; Kvernenes, Ole Heine; Schwarzlmüller, Thomas; Olesen, Rasmus Aamand; Hugdahl, Kenneth (Peer reviewed; Journal article, 2015-06)
      Over the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more ...
    • Dynamic up- and down-regulation of thedefault (DMN) and extrinsic (EMN) modenetworks during alternating task-on and task-offperiods 

      Hugdahl, Kenneth; Kazimierczak, Katarzyna Anna; Beresniewicz, Justyna; Kompus, Kristiina; Westerhausen, René; Ersland, Lars; Grüner, Renate; Specht, Karsten (Peer reviewed; Journal article, 2019)
      Using fMRI, Hugdahl et al. (2015) reported the existence of a general-domain cortical network during active task-processing which was non-specific to the cognitive task being processed. They labelled this network the ...
    • The effects of alcohol intoxication on neuronal activation at different levels of cognitive load 

      Gundersen, Hilde; Grüner, Renate; Specht, Karsten; Hugdahl, Kenneth (Peer reviewed; Journal article, 2008-08-22)
      The aim of this study was to investigate how alcohol intoxication at two blood alcohol concentrations (BAC) affected neuronal activation during increasing levels of cognitive load. For this purpose we used functional ...
    • Effects of Facial Symmetry and Gaze Direction on Perception of Social Attributes: A Study in Experimental Art History 

      Folgerø, Per Olav; Hodne, Lasse; Johansson, Christer; Andresen, Alf Edgar; Sætren, Lill Charlotte; Specht, Karsten; Skaar, Øystein Olav; Reber, Rolf (Journal article; Peer reviewed, 2016)
      This article explores the possibility of testing hypotheses about art production in the past by collecting data in the present. We call this enterprise “experimental art history”. Why did medieval artists prefer to paint ...
    • An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance 

      Heggdal, Peder Olaf Laugen; Aarstad, Hans Jørgen; Brännström, Jonas; Vassbotn, Flemming; Specht, Karsten (Peer reviewed; Journal article, 2019)
      Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in ...
    • The functional and structural asymmetries of the superior temporal sulcus 

      Specht, Karsten; Wigglesworth, Philip (Peer reviewed; Journal article, 2018-02)
      The superior temporal sulcus (STS) is an anatomical structure that increasingly interests researchers. This structure appears to receive multisensory input and is involved in several perceptual and cognitive core functions, ...
    • Functional asymmetry and effective connectivity of the auditory system during speech perception is modulated by the place of articulation of the consonant – A 7 T fMRI study 

      Specht, Karsten; Baumgartner, Florian; Stadler, Jörg; Hugdahl, Kenneth; Pollmann, Stefan (Peer reviewed; Journal article, 2014-06-11)
      To differentiate between stop-consonants, the auditory system has to detect subtle place of articulation (PoA) and voice-onset time (VOT) differences between stop-consonants. How this differential processing is represented ...
    • Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment 

      Kompus, Kristiina; Volehaugen, Vegard; Craven, Alexander R.; Specht, Karsten (Journal article; Peer reviewed, 2020)
      In a stable environment the brain can minimize processing required for sensory input by forming a predictive model of the surrounding world and suppressing neural response to predicted stimuli. Unpredicted stimuli lead to ...
    • The human amygdala encodes value and space during decision making 

      Ousdal, Olga Therese; Specht, Karsten; Server, Andres; Andreassen, Ole Andreas; Dolan, Ray J.; Jensen, Jimmy Kristian (Peer reviewed; Journal article, 2014-11-01)
      Valuable stimuli are invariably localized in space. While our knowledge regarding the neural networks supporting value assignment and comparisons is considerable, we lack a basic understanding of how the human brain ...
    • Impact of glutamate levels on neuronal response and cognitive abilities in schizophrenia 

      Falkenberg, Liv Eggset; Westerhausen, René; Craven, Alexander R.; Kroken, Rune A.; Løberg, Else-Marie; Specht, Karsten; Hugdahl, Kenneth (Peer reviewed; Journal article, 2014-04-02)
      Schizophrenia is characterized by impaired cognitive functioning, and brain regions involved in cognitive control processes show marked glutamatergic abnormalities. However, it is presently unclear whether aberrant neuronal ...