• Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma 

      Halle, Mari Kyllesø; Sundaresan, Aishwarya; Zhang, Jianqing; Pedamallu, Chandra S.; Srinivasasainagendra, Vinodh; Blair, Jessica; Brooke, Dewey; Bertelsen, Bjørn; Woie, Kathrine; Shrestha, Sadeep; Tiwari, Hemant K.; Wong, Yick Fu; Krakstad, Camilla; Ojesina, Akinyemi I (Journal article; Peer reviewed, 2021)
      Despite recent advances in the prevention of cervical cancer, the disease remains a leading cause of cancer-related deaths in women worldwide. By applying the GISTIC2.0 and/or the MutSig2CV algorithms on 430 whole-exome-sequenced ...
    • Genomic characterization and therapeutic targeting of HPV undetected cervical carcinomas 

      Ruiz, Fiona J.; Sundaresan, Aishwarya; Zhang, Jin; Pedamallu, Chandra S.; Halle, Mari K.; Srinivasasainagendra, Vinodh; Zhang, Jianqing; Muhammad, Naoshad; Stanley, Jennifer; Markovina, Stephanie; Tiwari, Hemant K.; Grigsby, Perry W.; Krakstad, Camilla; Schwarz, Julie K.; Ojesina, Akinyemi I. (Journal article; Peer reviewed, 2021)
      Cervical cancer tumors with undetectable HPV (HPVU) have been underappreciated in clinical decision making. In this study, two independent CC datasets were used to characterize the largest cohort of HPVU tumors to date ...