Browsing Bergen Open Research Archive by Author "Srivastava, Aashish"
Now showing items 1-10 of 10
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A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers
Ruiz-Manriquez, Luis M.; Ledesma Pacheco, Schoenstatt Janin; Medina-Gomez, Daniel; Uriostegui-Pena, Andrea G.; Estrada-Meza, Carolina; Bandyopadhyay, Anindya; Pathak, Surajit; Banerjee, Antara; Chakraborty, Samik; Srivastava, Aashish; Paul, Sujay (Journal article; Peer reviewed, 2022)miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases ... -
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck; Gullaksen, Stein-Erik; Srivastava, Aashish; Birkeland, Even; Kleftogiannis, Dimitrios; Ayuda Duran, Pilar; Piechaczyk, Laure Isabelle; Tadele, Dagim Shiferaw; Skavland, Jørn; Panagiotis, Baliakas; Hovland, Randi; Andresen, Vibeke; Seternes, Ole Morten; Tvedt, Tor Henrik Anderson; Aghaeepour, Nima; Gavasso, Sonia; Porkka, Kimmo; Jonassen, Inge; Fløisand, Yngvar; Enserink, Jorrit; Blaser, Nello; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2023)Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a ... -
Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India
Sivakumaran, Dhanasekaran; Jenum, Synne; Srivastava, Aashish; Steen, Vidar Martin; Vaz, Mario; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Journal article; Peer reviewed, 2023-01-11)A large proportion of the global tuberculosis (TB) burden is asymptomatic and not detectable by symptom-based screening, driving the TB epidemic through continued M. tuberculosis transmission. Currently, no validated tools ... -
Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism
Reyes-Calderón, Almendra; Gutiérrez-García, Claudia; Urióstegui-Pena, Andrea G.; Srivastava, Aashish; Aguilar-Marcelino, Liliana; Iqbal, Hafiz M. N.; Ahmed, Shiek S. S. J.; Paul, Sujay; Sharma, Ashutosh (Journal article; Peer reviewed, 2023-04-25)The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ... -
Identification of housekeeping genes of Candidatus Branchiomonas cysticola associated with epitheliocystis in Atlantic salmon (Salmo salar L.)
Mjølnerød, Even Bysveen; Srivastava, Aashish; Moore, Lindsey; Plarre, Heidrun; Nylund, Are (Journal article; Peer reviewed, 2022)Candidatus Branchiomonas cysticola is an intracellular, gram-negative Betaproteobacteria causing epitheliocystis in Atlantic Salmon (Salmo salar L.). The bacterium has not been genetically characterized at the intraspecific ... -
Identification of microRNAs from medicinal plant Murraya Koenigii by high-throughput sequencing and their functional implications in secondary metabolite biosynthesis
Gutiérrez-García, Claudia; Ahmed, Shiek S. S. J.; Ramalingam, Sathishkumar; Selvaraj, Dhivya; Srivastava, Aashish; Paul, Sujay; Sharma, Ashutosh (Journal article; Peer reviewed, 2022)MicroRNAs (miRNAs) are small noncoding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling. However, information about their involvement in ... -
Patient-derived organoids reflect the genetic profile of endometrial tumors and predict patient prognosis
Berg, Hege Fredriksen; Hjelmeland, Marta Espevold; Lien, Hilde Eide; Espedal, Heidi; Fonnes, Tina; Srivastava, Aashish; Stokowy, Tomasz; Strand, Elin; Bozickovic, Olivera; Stefansson, Ingunn Marie; Bjørge, Line; Trovik, Jone; Haldorsen, Ingfrid S.; Høivik, Erling Andre; Krakstad, Camilla (Journal article; Peer reviewed, 2021)Background: A major hurdle in translational endometrial cancer (EC) research is the lack of robust preclinical models that capture both inter- and intra-tumor heterogeneity. This has hampered the development of new treatment ... -
Protein and transcriptional biomarker profiling may inform treatment strategies in lower respiratory tract infections by indicating bacterial–viral differentiation
Sivakumaran, Dhanasekaran; Jenum, Synne; Markussen, Dagfinn Lunde; Serigstad, Sondre; Srivastava, Aashish; Saghaug, Christina Skår; Ulvestad, Elling; Knoop, Siri Tandberg; Grewal, Harleen (Journal article; Peer reviewed, 2024)Lower respiratory tract infections (LRTIs) remain a significant global cause of infectious disease-related mortality. Accurate discrimination between acute bacterial and viral LRTIs is crucial for optimal patient care, ... -
Radiomic profiles improve prognostication and reveal targets for therapy in cervical cancer
Halle, Mari Kyllesø; Hodneland, Erlend; Wagner-Larsen, Kari Strøno; Lura, Njål; Fasmer, Kristine Eldevik; Berg, Hege Fredriksen; Stokowy, Tomasz; Srivastava, Aashish; Forsse, David Erik; Høivik, Erling André; Woie, Kathrine; Bertelsen, Bjørn; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2024)Cervical cancer (CC) is a major global health problem with 570,000 new cases and 266,000 deaths annually. Prognosis is poor for advanced stage disease, and few effective treatments exist. Preoperative diagnostic imaging ... -
Thymoquinone Potentially Modulates the Expression of Key Onco- and Tumor Suppressor miRNAs in Prostate and Colon Cancer Cell Lines: Insights from PC3 and HCT-15 Cells
Osorio-Pérez, Sofía Madeline; Estrada-Meza, Carolina; Ruiz-Manriquez, Luis M.; Arvizu-Espinosa, María Goretti; Srivastava, Aashish; Sharma, Ashutosh; Paul, Sujay (Journal article; Peer reviewed, 2023)Prostate cancer (PC) and colon cancer significantly contribute to global cancer-related morbidity and mortality. Thymoquinone (TQ), a naturally occurring phytochemical found in black cumin, has shown potential as an ...