• Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders 

      Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Reponen, Elina Johanna; Steen, Vidar Martin; Andreassen, Ole Andreas; Melle, Ingrid (Peer reviewed; Journal article, 2019-03-08)
      Objective: Associations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We examined the association between leptin and suicidal behaviour in ...
    • Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. 

      Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Iversen, Trude Seselie Jahr; Steen, Vidar Martin; Andreassen, Ole Andreas; Melle, Ingrid (Peer reviewed; Journal article, 2018-05-02)
      Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. ...
    • Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders 

      Reponen, Elina Johanna; Dieset, Ingrid; Tesli, Martin Steen; Mørch, Ragni Helene; Aas, Monica; Vedal, Trude Seselie Jahr; Haug, Elisabeth; Drange, Ole Kristian; Steen, Nils Eiel; Hope, Sigrun; Szabo, Attila; Gohar, Sherif Mostafa Mohamed Ahmed; Wedervang-Resell, Kirsten; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Peer reviewed, 2020)
      Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade ...
    • Attenuated Notch signaling in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018-03-28)
      The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ...
    • Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking 

      Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2021)
      Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated ...
    • Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells 

      Akkouh, Ibrahim; Ueland, Thor; Hansson, Lars; Inderhaug, Elin; Hughes, Timothy; Steen, Nils Eiel; Aukrust, Pål; Andreassen, Ole Andreas; Szabo, Attila; Djurovic, Srdjan (Journal article; Peer reviewed, 2020)
      Schizophrenia (SCZ) is a severe mental disorder with a high heritability. Although its pathophysiology is mainly unknown, dysregulated immune activation and inflammation have recently emerged as possible candidates in the ...
    • Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018)
      The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with ...
    • Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes 

      Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Chu, Yunhan; Shadrin, Alexey A.; O'Connell, Kevin S.; Smeland, Olav Bjerkehagen; Elvsåshagen, Torbjørn; Hindley, Guy Frederick Lanyon; Djurovic, Srdjan; Dale, Anders; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2021)
      Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic ...
    • Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence 

      Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)
      Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ...
    • Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci 

      Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Bahrami, Shahram; Broce, Iris J.; Tesli, Martin Steen; Frei, Oleksandr; Wirgenes, Katrine Verena; O`Connell, Kevin; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Sugrue, Leo P.; Wang, Yunpeng; Svenningsson, Per; Sharma, Manu; Pihlstrøm, Lasse; Toft, H. Mathias S.; O’Donovan, Michael; Djurovic, Srdjan; Desikan, Rahul S; Dale, Anders M.; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2021)
      Background Parkinson’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the ...
    • Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment 

      O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified ...
    • Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder 

      O`Connell, Kevin; Shadrin, Alexey A.; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Frei, Oleksandr; Krull, Florian; Askeland, Ragna Bugge; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyða; Guðmundsson, Ólafur; Stefánsson, Hreinn; Fan, Chun C.; Steen, Nils Eiel; Reichborn-Kjennerud, Ted; Dale, Anders; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)
      Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to overlapping symptoms and high rates of comorbidity. Despite this, ...
    • Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients 

      Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill; Andreassen, Ole Andreas; Steen, Vidar Martin; Melle, Ingrid (Peer reviewed; Journal article, 2019-04-27)
      To investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two ...
    • Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Steen, Nils Eiel (Journal article; Peer reviewed, 2020)
      Background One third of people diagnosed with schizophrenia fail to respond adequately to antipsychotic medication, resulting in persisting disabling symptoms, higher rates of hospitalization and higher costs for society. ...
    • Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders 

      Osete, Jordi Requena; Akkouh, Ibrahim; Reis de Assis, Denis; Szabo, Attila; Frei, Evgeniia; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)
      Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely ...
    • Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders 

      Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      Background: We aimed at exploring potential pathophysiological processes across psychotic disorders, applying metabolomics in a large and well-characterized sample of patients and healthy controls. Methods: Patients with ...
    • Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms 

      Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; O'Connell, Kevin; Elvsåshagen, Torbjørn; Winterton, Adriano; Quintana, Daniel; Hindley, Guy Frederick Lanyon; Werner, Maren Caroline Frogner; Djurovic, Srdjan; Dale, Anders Martin; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2021)
      Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship ...
    • Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative 

      Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta; Bellivier, Frank (Peer reviewed; Journal article, 2019-09-25)
      Background Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains ...