Browsing Bergen Open Research Archive by Author "Steinsland, Hans"
Now showing items 1-12 of 12
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Characterization of Glycosylation-Specific Systemic and Mucosal IgA Antibody Responses to Escherichia coli Mucinase YghJ (SslE)
Riaz, Saman; Steinsland, Hans; Thorsing, Mette; Andersen, Ann Z.; Boysen, Anders T.; Hanevik, Kurt (Journal article; Peer reviewed, 2021)Efforts to develop broadly protective vaccines against pathogenic Escherichia coli are ongoing. A potential antigen candidate for vaccine development is the metalloprotease YghJ, or SslE. YghJ is a conserved mucinase that ... -
Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection
Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan; Gullaksen, Stein-Erik; Skavland, Jørn; Chauhan, Sudhir Kumar; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2023)Enterotoxigenic Escherichia coli (ETEC) is an important cause of children's and travelers’ diarrhea, with no licensed vaccine. This study aimed to explore the role of cellular immunity in protection against human ETEC ... -
Experimental infection of healthy volunteers with enterotoxigenic Escherichia coli wild-type strain TW10598 in a hospital ward
Skrede, Steinar; Steinsland, Hans; Sommerfelt, Halvor; Aase, Audun; Brandtzaeg, Per; Langeland, Nina; Cox, Rebecca Jane; Sævik, Marianne; Wallevik, Marita; Skutlaberg, Dag Harald; Tellevik, Marit Gjerde; Sack, David A.; Nataro, James P.; Guttormsen, Anne Berit (Peer reviewed; Journal article, 2014-09-04)Background: Enterotoxigenic Escherichia coli (ETEC) is an important cause of childhood diarrhea in resource-limited regions. It is also an important cause of diarrhea in travellers to these areas. To evaluate the protective ... -
Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Kleppa, Elisabeth; Lillebø, Kristine; Sævik, Marianne; Søyland, Hanne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen M.; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-06-22)Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled ... -
Human mucosal IgA immune responses against enterotoxigenic escherichia coli
Riaz, Saman; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2020-08-29)Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ... -
A New Human Challenge Model for Testing Heat-Stable Toxin-Based Vaccine Candidates for Enterotoxigenic Escherichia Coli Diarrhea - Dose Optimization, Clinical Outcomes, and CD4+ T Cell Responses
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Rykkje Heien, Astrid; Gjerde Tellevik, Marit; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt (Peer reviewed; Journal article, 2019-10-30)Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy ... -
Proliferation of enterotoxigenic Escherichia coli strain TW11681 in stools of experimentally infected human volunteers
Vedøy, Oda Barth; Hanevik, Kurt; Sakkestad, Sunniva Todnem; Sommerfelt, Halvor; Steinsland, Hans (Peer reviewed; Journal article, 2018-10-16)Background: As part of the efort to develop an enterotoxigenic Escherichia coli (ETEC) human challenge model for testing new heat-stable toxin (ST)-based vaccine candidates, a controlled human infection model study based ... -
Reduced Plasma Guanylin Levels Following Enterotoxigenic Escherichia coli-Induced Diarrhea
Brønstad, Ingeborg; Volkmann, Hilde Løland Von; Sakkestad, Sunniva Todnem; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2023)The intestinal peptide hormones guanylin (GN) and uroguanylin (UGN) interact with the epithelial cell receptor guanylate cyclase C to regulate fluid homeostasis. Some enterotoxigenic Escherichia coli (ETEC) produce heat-stable ... -
Strong Association between Diarrhea and Concentration of Enterotoxigenic Escherichia coli Strain TW10722 in Stools of Experimentally Infected Volunteers
Vedøy, Oda Barth; Steinsland, Hans; Sakkestad, Sunniva Todnem; Sommerfelt, Halvor; Hanevik, Kurt (Journal article; Peer reviewed, 2023)Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal illness in children and travelers in low- and middle-income countries. When volunteers are infected with ETEC strains, as part of experimental ... -
Umbilical Cord Stump Infections in Central Uganda: Incidence, Bacteriological Profile, and Risk Factors
Tumuhamye, Josephine; Sommerfelt, Halvor; Tumwine, James K; Mukunya, David; Ndeezi, Grace; Namugga, Olive; Bwanga, Freddie; Steinsland, Hans; Nankabirwa, Victoria (Journal article; Peer reviewed, 2022)Umbilical cord stump infection (omphalitis) is a risk factor for neonatal sepsis and death. We assessed the incidence of omphalitis, described the bacteriological and antibiotic-resistance profile of potentially pathogenic ... -
Vaginal colonisation of women in labour with potentially pathogenic bacteria: A cross sectional study at three primary health care facilities in Central Uganda
Tumuhamye, Josephine; Steinsland, Hans; Tumwine, James K.; Namugga, Olive; Mukunya, David; Bwanga, Freddie; Sommerfelt, Halvor; Nankabirwa, Victoria (Journal article; Peer reviewed, 2020-01-31)Background: Potentially pathogenic bacteria that colonise the lower genital tract of women in labour can be passed to the baby during birth. While many babies become colonised with these bacteria after delivery, a few ... -
Vaginal colonization with antimicrobial-resistant bacteria among women in labor in central Uganda: prevalence and associated factors
Tumuhamye, Josephine; Steinsland, Hans; Bwanga, Freddie; Tumwine, James K.; Ndeezi, Grace; Mukunya, David; Namugga, Olive; Napyo, Agnes Kasede; Sommerfelt, Halvor; Nankabirwa, Victoria (Journal article; Peer reviewed, 2021)Background According to WHO ( CISMAC. Centre for Intervention Science in Maternal and Child health), the antimicrobial resistant bacteria considered to be clinically most important for human health and earmarked for ...