Blar i Bergen Open Research Archive på forfatter "Stokkevåg, Camilla Hanquist"
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A case-control study of linear energy transfer and relative biological effectiveness related to symptomatic brainstem toxicity following pediatric proton therapy
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland; Lassen-Ramshad, Yasmin; Muren, Ludvig Paul; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2022)Background and purpose A fixed relative biological effectiveness (RBE) of 1.1 (RBE1.1) is used clinically in proton therapy even though the RBE varies with properties such as dose level and linear energy transfer (LET). ... -
The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
Dahle, Tordis Johnsen; Rusten, Espen; Stokkevåg, Camilla Hanquist; Silvoniemi, Antti; Mairani, Andrea; Fjæra, Lars Fredrik; Rørvik, Eivind; Henjum, Helge; Wright, Pauliina; Boer, Camilla Grindeland; Forsback, Sarita; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)Introduction The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of ... -
Implementation of a double scattering nozzle for Monte Carlo recalculation of proton plans with variable relative biological effectiveness
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Stokkevåg, Camilla Hanquist; Muren, Ludvig Paul; Hsi, Wen C.; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)A constant relative biological effectiveness (RBE) of 1.1 is currently used in clinical proton therapy. However, the RBE varies with factors such as dose level, linear energy transfer (LET) and tissue type. Multiple RBE ... -
Influence of beam pruning techniques on LET and RBE in proton arc therapy
Henjum, Helge; Tjelta, Johannes; Fjæra, Lars Fredrik; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Lyngholm, Erlend; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)Introduction: Proton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk. We aimed to investigate if pruning ... -
Inter-patient variations in relative biological efectiveness for craniospinal irradiation with protons
Ytre-Hauge, Kristian; Fjæra, Lars Fredrik; Rørvik, Eivind; Dahle, Tordis Johnsen; Dale, Jon Espen; Pilskog, Sara; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2020)Cranio-spinal irradiation (CSI) using protons has dosimetric advantages compared to photons and is expected to reduce risk of adverse effects. The proton relative biological effectiveness (RBE) varies with linear energy ... -
Linear energy transfer-inclusive models of brainstem necrosis following proton therapy of paediatric ependymoma
Handeland, Andreas Havsgård; Indelicato, Daniel J.; Fjæra, Lars Fredrik; Ytre-Hauge, Kristian Smeland; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2023)Background and Purpose Radiation-induced brainstem necrosis after proton therapy is a severe toxicity with potential association to uncertainties in the proton relative biological effectiveness (RBE). A constant RBE of ... -
Measurements of the Photonuclear Neutron Yield During Radiotherapy Using Bubble Detectors and Thermoluminescence Detectors
Stokkevåg, Camilla Hanquist (Master thesis, 2010-02-22)Medical linear accelerators (linacs) used for radiotherapy with photons produce an undesirable neutron contribution as treatment energies exceed the (γ,n) threshold of the high-Z constituents of the linac. Secondary neutrons ... -
Mixed Effect Modeling of Dose and Linear Energy Transfer Correlations With Brain Image Changes After Intensity Modulated Proton Therapy for Skull Base Head and Neck Cancer
Engeseth, Grete May; He, Renjie; Mirkovic, Dragan; Yepes, Pablo; Mohamed, Abdallah Sherif Radwan; Stieb, Sonja; Fuller, Clifton Dave; Wu, Richard; Zhang, Xiadong; Hysing, Liv Bolstad; Pettersen, Helge Egil Seime; Stokkevåg, Camilla Hanquist; Mohan, Radhe; Frank, Steven Jay; Gunn, Gary Brandon (Journal article; Peer reviewed, 2021)Purpose Intensity modulated proton therapy (IMPT) could yield high linear energy transfer (LET) in critical structures and increased biological effect. For head and neck cancers at the skull base this could potentially ... -
Spatial Agreement of Brainstem Dose Distributions Depending on Biological Model in Proton Therapy for Pediatric Brain Tumors
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Ytre-Hauge, Kristian; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Toussaint, Laura; Dahl, Olav; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)Purpose During radiation therapy for pediatric brain tumors, the brainstem is a critical organ at risk, possibly with different radio-sensitivity across its substructures. In proton therapy, treatment planning is currently ... -
Variation in relative biological effectiveness for cognitive structures in proton therapy of pediatric brain tumors
Otterlei, Ole Marius; Indelicato, Daniel J.; Toussaint, Laura; Ytre-Hauge, Kristian; Pilskog, Sara; Fjæra, Lars Fredrik; Rørvik, Eivind; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Di Pinto, Marcos; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)Background Clinically, a constant value of 1.1 is used for the relative biological effectiveness (RBE) of protons, whereas in vitro the RBE has been shown to vary depending on physical dose, tissue type, and linear energy ...