• The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection 

      Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly; Ødegaard-Fougner, Øyvind; Strømland, Øyvind; Martin, Stephen R.; De Marco, Valeria; Christodoulou, Evangelos; Teigen, Knut; Isaksson, Johan; Underhaug, Jarl; Reuter, Nathalie; Aalen, Reidunn B.; Aasland, Rein; Halskau, Øyvind (Journal article; Peer reviewed, 2020)
      Chromatin post‐translational modifications are thought to be important for epigenetic effects on gene expression. Methylation of histone N‐terminal tail lysine residues constitutes one of many such modifications, executed ...
    • The balance between NAD+ biosynthesis and consumption in ageing 

      Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ...
    • Detection of misfolded protein aggregates from a clinical perspective 

      Jakubec, Martin; Strømland, Øyvind; Furse, Samuel Robert; Halskau, Øyvind (Peer reviewed; Journal article, 2016)
      Neurodegenerative Protein Misfolding Diseases (PMDs), such as Alzheimer’s (AD), Parkinson’s (PD) and prion diseases, are generally difficult to diagnose before irreversible damage to the central nervous system damage has ...
    • Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles 

      Dobrovolska, Olena; Strømland, Øyvind; Handegård, Ørjan Sele; Jakubec, Martin; Govasli Larsen, Morten Andreas; Skjevik, Åge Aleksander; Frøystein, Nils Åge; Teigen, Knut; Halskau, Øyvind (Journal article; Peer reviewed, 2021)
      The driving forces and conformational pathways leading to amphitropic protein-membrane binding and in some cases also to protein misfolding and aggregation is the subject of intensive research. In this study, a chimeric ...
    • α-lactalbumin: oleic acid complex spontaneously delivers oleic acid to artificial and erythrocyte membranes 

      Wen, Hanzhen; Strømland, Øyvind; Halskau, Øyvind (Peer reviewed; Journal article, 2015-08-19)
      Human α-lactalbumin made lethal to tumor cells (HAMLET) is a tumoricidal complex consisting of human α-lactalbumin and multiple oleic acids (OAs). OA has been shown to play a key role in the activity of HAMLET and its ...