Browsing Bergen Open Research Archive by Author "Strømland, Øyvind"

Now showing items 1-10 of 10

    • The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection 

      Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly; Ødegaard-Fougner, Øyvind; Strømland, Øyvind; Martin, Stephen R.; De Marco, Valeria; Christodoulou, Evangelos; Teigen, Knut; Isaksson, Johan; Underhaug, Jarl; Reuter, Nathalie; Aalen, Reidunn B.; Aasland, Rein; Halskau, Øyvind (Journal article; Peer reviewed, 2020)
      Chromatin post‐translational modifications are thought to be important for epigenetic effects on gene expression. Methylation of histone N‐terminal tail lysine residues constitutes one of many such modifications, executed ...

    • The balance between NAD+ biosynthesis and consumption in ageing 

      Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ...

    • Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix 

      Bril'kov, Maxim; Dobrovolska, Olena; Ødegård-Fougner, Øyvind; Turcu, Diana Cornelia; Strømland, Øyvind; Underhaug, Jarl; Aasland, Rein; Halskau, Øyvind (Journal article; Peer reviewed, 2022-04-13)
      The CW domain binds to histone tail modifications found in different protein families involved in epigenetic regulation and chromatin remodeling. CW domains recognize the methylation state of the fourth lysine on histone ...

    • Detection of misfolded protein aggregates from a clinical perspective 

      Jakubec, Martin; Strømland, Øyvind; Furse, Samuel Robert; Halskau, Øyvind (Peer reviewed; Journal article, 2016)
      Neurodegenerative Protein Misfolding Diseases (PMDs), such as Alzheimer’s (AD), Parkinson’s (PD) and prion diseases, are generally difficult to diagnose before irreversible damage to the central nervous system damage has ...

    • Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria 

      Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Peer reviewed, 2022)
      Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other ...

    • Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles 

      Dobrovolska, Olena; Strømland, Øyvind; Handegård, Ørjan Sele; Jakubec, Martin; Govasli Larsen, Morten Andreas; Skjevik, Åge Aleksander; Frøystein, Nils Åge; Teigen, Knut; Halskau, Øyvind (Journal article; Peer reviewed, 2021)
      The driving forces and conformational pathways leading to amphitropic protein-membrane binding and in some cases also to protein misfolding and aggregation is the subject of intensive research. In this study, a chimeric ...

    • Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase 

      Ferrario, Eugenio; Kallio, Juha Pekka; Strømland, Øyvind; Ziegler, Mathias (Journal article; Peer reviewed, 2023)
      Nicotinamide adenine dinucleotide (NAD) is an essential molecule in all kingdoms of life, mediating energy metabolism and cellular signaling. Recently, a new class of highly active fungal surface NADases was discovered. ...

    • PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities 

      Đukić, Nina; Strømland, Øyvind; Elsborg, Jonas Damgaard; Munnur, Deeksha; Zhu, Kang; Schuller, Marion; Chatrin, Chatrin; Kar, Pulak; Duma, Lena; Suyari, Osamu; Rack, Johannes Gregor Matthias; Baretić, Domagoj; Crudgington, Dorian Richard Kenneth; Groslambert, Joséphine; Fowler, Gerissa; Wijngaarden, Sven; Prokhorova, Evgeniia; Rehwinkel, Jan; Schüler, Herwig; Filippov, Dmitri V.; Sanyal, Sumana; Ahel, Dragana; Nielsen, Michael L.; Smith, Rebecca; Ahel, Ivan (Journal article; Peer reviewed, 2023)
      PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its ...

    • Updated protein domain annotation of the PARP protein family sheds new light on biological function 

      Suskiewicz, Marcin J.; Munnur, Deeksha; Strømland, Øyvind; Yang, Ji-Chun; Easton, Laura E.; Chatrin, Chatrin; Zhu, Kang; Baretić, Domagoj; Goffinont, Stéphane; Schuller, Marion; Wu, Wing-Fung; Elkins, Jonathan M.; Ahel, Dragana; Sanyal, Sumana; Neuhaus, David; Ahel, Ivan (Journal article; Peer reviewed, 2023)
      AlphaFold2 and related computational tools have greatly aided studies of structural biology through their ability to accurately predict protein structures. In the present work, we explored AF2 structural models of the 17 ...

    • α-lactalbumin: oleic acid complex spontaneously delivers oleic acid to artificial and erythrocyte membranes 

      Wen, Hanzhen; Strømland, Øyvind; Halskau, Øyvind (Peer reviewed; Journal article, 2015-08-19)
      Human α-lactalbumin made lethal to tumor cells (HAMLET) is a tumoricidal complex consisting of human α-lactalbumin and multiple oleic acids (OAs). OA has been shown to play a key role in the activity of HAMLET and its ...