Blar i Bergen Open Research Archive på forfatter "Strauss, Philipp"
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AGAP2-AS1 as a prognostic biomarker in low-risk clear cell renal cell carcinoma patients with progressing disease
Strauss, Philipp; Marti, Hans-Peter; Furriol, Jessica; Nakken, Sigrid; Vidar, Beisvåg; Eikrem, Øystein Solberg; Beisland, Christian; Flatberg, Arnar; Bostad, Leif; Scherer, Andreas; Eleni, Skandalou (Journal article; Peer reviewed, 2021)Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and one of the most common cancers. While survival for localized ccRCC is good, the survival of metastatic disease is not, and ... -
Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis
Landolt, Lea Zoe; Eikrem, Øystein Solberg; Strauss, Philipp; Scherer, Andreas; Lovett, David H.; Beisland, Christian; Finne, Kenneth; Osman, Tarig Al-Hadi; Ibrahim, Mohammad Madani; Gausdal, Gro; Ahmed, Lavina; Lorens, James; Thiery, Jean Paul; Tan, Tuan Zea; Sekulic, Miroslav; Marti, Hans-Peter (Peer reviewed; Journal article, 2017)Clear cell renal cell carcinoma (ccRCC) represents the most common type of kidney cancer with high mortality in its advanced stages. Our study aim was to explore the correlation between tumor epithelial-to-mesenchymal ... -
Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma
Strauss, Philipp; Marti, Hans-Peter; Beisland, Christian; Scherer, Andreas; Lysne, Vegard; Leh, Sabine Maria; Flatberg, Arnar; Koch, Even Evjen; Beisvag, Vidar; Landolt, Lea Zoe; Skogstrand, Trude; Eikrem, Øystein Solberg (Peer reviewed; Journal article, 2018-03-10)Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives ... -
Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys
Eikrem, Øystein Solberg; Walther, Tedd Christian; Flatberg, Arnar; Beisvag, Vidar; Strauss, Philipp; Farstad, Magnus; Beisland, Christian; Koch, Even; Mueller, Thomas F.; Marti, Hans-Peter (Peer reviewed; Journal article, 2018-09-18)Background: Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current ... -
From archival tissues to systems biology: Using transcriptomics to investigate the progression of kidney disease
Strauss, Philipp (Doctoral thesis, 2023-03-13)Innledning: Både nyrecellekarsinom og Fabrys sykdom påvirker nyrene på en progressiv måte. Gjennom bruk av RNA-sekvenserings teknologi kan man predikere og øke forståelsen av de ulike mekanismene som driver denne ... -
Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy
Rivedal, Mariell Lossius; Mikkelsen, Håvard; Marti, Hans Peter; Liu, Lili; Kiryluk, Krzysztof; Knoop, Thomas; Bjørneklett, Rune Oskar; Haaskjold, Yngvar Lunde; Furriol Palmer, Jessica; Leh, Sabine; Paunas, Flavia Teodora Ioana; Babickova, Janka; Scherer, Andreas; Serre, Camille Julia; Eikrem, Øystein Solberg; Strauss, Philipp (Journal article; Peer reviewed, 2024)Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between ... -
A multiomics disease progression signature of low-risk ccRCC
Strauss, Philipp; Rivedal, Mariell; Scherer, Andreas; Eikrem, Øystein Solberg; Nakken, Sigrid; Beisland, Christian; Bostad, Leif; Flatberg, Arnar; Skandalou, Eleni; Beisvag, Vidar; Furriol, Jessica; Marti, Hans Peter (Journal article; Peer reviewed, 2022)Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ... -
Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target
Eikrem, Øystein Solberg; Lillefosse, Bjørnar; Delaleu, Nicolas; Strauss, Philipp; Osman, Tarig Al-Hadi; Vikse, Bjørn Egil; Debiec, Hanna; Ronco, Pierre; Sekulic, Miroslav; Koch, Even Evjen; Furriol, Jessica; Leh, Sabine; Marti, Hans Peter (Journal article; Peer reviewed, 2023)Background: Minimal change disease (MCD), a major cause of nephrotic syndrome, is usually treated by corticosteroid administration. MCD unresponsiveness to therapy and recurrences are nonetheless frequently observed, ... -
Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing
Delaleu, Nicolas; Marti, Hans Peter; Strauss, Philipp; Sekulic, Miroslav; Osman, Tarig Al-Hadi; Tøndel, Camilla; Skrunes, Rannveig; Leh, Sabine; Svarstad, Einar; Nowak, Albina; Gaspert, Ariana; Rusu, Elena; Kwee, Ivo; Rinaldi, Andrea; Flatberg, Arnar; Eikrem, Øystein Solberg (Journal article; Peer reviewed, 2023)Fabry disease is a rare disorder caused by variations in the alpha-galactosidase gene. To a degree, Fabry disease is manageable via enzyme replacement therapy (ERT). By understanding the molecular basis of Fabry nephropathy ... -
Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies
Strauss, Philipp; Furriol, Jessica; Mikkelsen, Håvard (Journal article; Peer reviewed, 2021)Housekeeping, or reference genes (RGs) are, by definition, loci with stable expression profiles that are widely used as internal controls to normalize mRNA levels. However, due to specific events, such as pathological ...