• Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Peer reviewed; Journal article, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
    • The effect of stromal integrin β3-deficiency on two different tumors in mice 

      Reigstad, Inga; Sortland, Kristina; Skogstrand, Trude; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2016-01-12)
    • Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats 

      Bjørkum, Alvhild Alette; Oveland, Eystein; Stuhr, Linda Elin Birkhaug; Havnes, Marianne Bjordal; Berven, Frode; Grønning, Marit; Hope, Arvid (Peer reviewed; Journal article, 2017-10-04)
      Better understanding of the physiological mechanisms and neurological symptoms involved in the development of decompression sickness could contribute to improvements of diving procedures. The main objective of the present ...
    • Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation 

      Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2012-01-17)
      Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ...
    • Hyperbaric oxygen therapy and cancer—a review 

      Moen, Ingrid; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2012-10-02)
      Hypoxia is a critical hallmark of solid tumors and involves enhanced cell survival, angiogenesis, glycolytic metabolism, and metastasis. Hyperbaric oxygen (HBO) treatment has for centuries been used to improve or cure ...
    • Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma 

      Moen, Ingrid; Tronstad, Karl Johan; Kolmannskog, Odd; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2009-12-17)
      Background: Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and ...
    • Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors 

      Raa, Anette; Stansberg, Christine; Steen, Vidar Martin; Bjerkvig, Rolf; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Journal article, 2007-01-30)
      This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors. Methods: One group of animals was exposed to normobaric ...
    • Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model 

      Moen, Ingrid; Øyan, Anne Margrete; Kalland, Karl-Henning; Tronstad, Karl Johan; Akslen, Lars A.; Chekenya, Martha; Sakariassen, Per Øystein; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2009-07-28)
      Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-be ...
    • Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice 

      Friman, Tomas; Gustafsson, Renata; Stuhr, Linda Elin Birkhaug; Chidiac, Jean; Heldin, Nils-Erik; Reed, Rolf K.; Oldberg, Åke; Rubin, Kristofer (Peer reviewed; Journal article, 2012-03-30)
      Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that αVβ3 expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), ...
    • Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes 

      Smeland, Hilde Ytre-Hauge; Askeland, Cecilie; Wik, Elisabeth; Knutsvik, Gøril; Molven, Anders; Edelmann, RJ; Reed, Rolf K.; Warren, DJ; Gullberg, Donald; Stuhr, Linda Elin Birkhaug; Akslen, Lars A. (Peer reviewed; Journal article, 2020)
      Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. ...
    • Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts 

      Sletta, Kristine Yttersian; Tveitarås, Maria Kathrine; Lu, Ning; Svendsen, Agnete; Reed, Rolf K.; Garmann-Johnsen, Annette; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2017-08-23)
      Background: Tumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy and metastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment (HBOT), attenuates tumor growth and ...
    • Protein expression profiling of plasma and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model. 

      TVEITARÅS, MK; Selheim, Frode; Sortland, Kristina; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2019-05-01)
      The main objective of this study was to identify single proteins or protein networks that might be used as diagnostic biomarkers or for therapeutic purposes by evaluating the protein expression profiling of plasma and lungs ...
    • A rat model of radiation injury in the mandibular area 

      Sønstevold, Tonje; Johannessen, Anne Christine; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2015-06-09)
      Background Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. Injuries to the surrounding ...
    • Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression 

      PRIMAC, I; MAQUOI, E; BLACHER, S; HELJASVAARA, R; Van Deun, Jan; Smeland, Hilde Ytre-Hauge; CANALE, A; LOUIS, T; Stuhr, Linda Elin Birkhaug; SOUNNI, NE; CATALDO, D; PIHLAJANEMI, T; PEQUEUX, C; DE WEAVER, O; Gullberg, Donald; Noel, Agnes (Peer reviewed; Journal article, 2019)
      Cancer-associated fibroblasts (CAFs) are key actors in modulating the progression of many solid tumors, such as breast cancer (BC). Herein, we identify an integrin α11/PDGFRβ–positive CAF subset displaying tumor-promoting ...
    • Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors 

      Smeland, Hilde Ytre-Hauge; Lu, Ning; Karlsen, Tine Veronica; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2019-03-15)
      Background: Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the ...
    • Stromal integrin α11β1 affects RM11 prostate and 4T1 breast xenograft tumors differently 

      Reigstad, Inga; Smeland, Hilde Ytre-Hauge; Skogstrand, Trude; Sortland, Kristina; Schmid, Caroline; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2016-03-18)
      Purpose It has been implied that the collagen binding integrin α11β1 plays a role in carcinogenesis. As still relatively little is known about how the stromal integrin α11β1 affects different aspects of tumor development, ...