Browsing Bergen Open Research Archive by Author "Suliman, Salwa"

Now showing items 1-20 of 22

    • Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison 

      Mohamed-Ahmed, Samih; Fristad, Inge; Lie, Stein Atle; Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Vindenes, Hallvard; Idris, Shaza Bushra M. (Journal article; Peer reviewed, 2018-06)
      Background Adipose-derived stem cells (ASCs) have been introduced as an alternative to bone marrow mesenchymal stem cells (BMSCs) for cell-based therapy. However, different studies comparing ASCs and BMSCs have shown ...

    • AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction 

      Landolt, Lea Zoe; Furriol, Jessica; Babickova, Janka; Ahmed, Lavina; Eikrem, Øystein Solberg; Skogstrand, Trude; Scherer, Andreas; Suliman, Salwa; Leh, Sabine Maria; Lorens, James; Gausdal, Gro; Marti, Hans-Peter; Osman, Tarig Al-Hadi (Peer reviewed; Journal article, 2019)
      The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ...

    • Bioactive copolymer scaffolds for bone tissue engineering. Efficacy and host response 

      Suliman, Salwa (Doctoral thesis, 2015-12-11)
      Current research focuses on developing a novel bone-inducing scaffold that could deliver controlled osteogenic growth factors. Several aspects, in particular those influencing the efficacy of such bioactive scaffolds, such ...

    • Bone regeneration in rat calvarial defects using dissociated or spheroid mesenchymal stromal cells in scaffold-hydrogel constructs 

      Shanbhag, Siddharth; Suliman, Salwa; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kampleitner, Carina; Hassan, Mohamed Nageeb; Heimel, Patrick; Dobsak, Toni; Tangl, Stefan; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)
      Background Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). 3D printing offers the possibility to produce customized scaffolds for complex ...

    • Contact osteogenesis by biodegradable 3D-printed poly(lactide-co-trimethylene carbonate) 

      Hassan, Mohamad Nageeb Abdelaziz; Yassin, Mohammed Ahmed; Eltawila, Ahmed Maher; Aladawi, Ahmed Emad; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Suliman, Salwa; Kandil, Sherif; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)
      Background To support bone regeneration, 3D-printed templates function as temporary guides. The preferred materials are synthetic polymers, due to their ease of processing and biological inertness. Poly(lactide-co-trimethylene ...

    • Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs 

      Shanbhag, Siddharth; Kampleitner, Carina; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Yassin, Mohammed Ahmed Alamin Yousif; Dongre, Harsh Nitin; Costea, Daniela Elena; Tangl, Stefan; Stavropoulos, Andreas; Bolstad, Anne Isine; Suliman, Salwa; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021-11-30)
      Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation and bone regeneration capacity of mesenchymal stromal cells (MSC). Gingiva-derived progenitor cells (GPC) represent a less invasive alternative ...

    • Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration 

      Munir, Arooj; Døskeland, Anne; Avery, Steven J; Fuoco, Tiziana; Mohamed Ahmed, Samih; Lygre, Henning; Finne-Wistrand, Anna; Sloan, Alastair J; Waddington, Rachel J; Mustafa, Kamal Babikeir Eln; Suliman, Salwa (Journal article; Peer reviewed, 2019)
      Poly(L-lactide-co-ε-caprolactone) scaffolds were functionalised by 10 or 20 µg/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after ...

    • Embryonic Stem Cells Can Generate Oral Epithelia under Matrix Instruction 

      Das, Ridhima; Harper, Lisa; Kitajima, Kayoko; Osman, Tarig Al-Hadi; Cimpan, Mihaela-Roxana; Johannessen, Anne Christine; Suliman, Salwa; Mackenzie, Ian C.; Costea, Daniela Elena (Journal article; Peer reviewed, 2023)
      We aimed to investigate whether molecular clues from the extracellular matrix (ECM) can induce oral epithelial differentiation of pluripotent stem cells. Mouse embryonic stem cells (ESC) of the feeder-independent cell line ...

    • Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds. 

      Suliman, Salwa; Parajuli, Himalaya; Sun, Yang; Johannessen, Anne Christine; Finne-Wistrand, Anna; McCormack, Emmet; Mustafa, Kamal Babikeir Eln; Costea, Daniela Elena (Peer reviewed; Journal article, 2015)
      Background: Microenvironmental cues play a major role in head and neck cancer. Biodegradable scaffolds used for bone regeneration might also act as stimulative cues for head and neck cancer. The purpose of this study was ...

    • Extracellular Vesicles Derived from Primed Mesenchymal Stromal Cells Loaded on Biphasic Calcium Phosphate Biomaterial Exhibit Enhanced Macrophage Polarization 

      Rana, Neha; Suliman, Salwa; Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2022)
      Mesenchymal stromal cells (MSC) loaded on biphasic calcium phosphate biomaterial (MSC + BCP) have been used as an advanced therapy medicinal product to treat complex maxillofacial bone defects in patients. Further, MSC-derived ...

    • Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration 

      Suliman, Salwa; Mieszkowska, Anna; Folkert, Justyna; Rana, Neha; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Fuoco, Tiziana; Finne-Wistrand, Anna; Dirscherl, Kai; Jørgensen, Bodil; Mustafa, Kamal Babikeir Elnour; Gurzawska-Comis, Katarzyna (Journal article; Peer reviewed, 2022)
      Background Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly ...

    • Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells 

      Suliman, Salwa; Ali, Hassan Mohamed Abdel-Raouf; Karlsen, Tommy Aleksander; Amiaud, Jérôme; Mohamed Ahmed, Samih; Layrolle, Pierre; Costea, Daniela Elena; Brinchmann, Jan E.; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2019-11-05)
      Therapeutic potential of human bone marrow stromal/stem cells (hBMSC) must be developed using well defined xenogenic-free conditions. hBMSC were isolated from healthy donors (n = 3) using different isolation and expansion ...

    • In vivo host response and degradation of copolymer scaffolds functionalized with nanodiamonds and bone morphogenetic protein 2 

      Suliman, Salwa; Sun, Yang; Pedersen, Torbjørn Østvik; Xue, Ying; Nickel, Joachim; Waag, Thilo; Finne-Wistrand, Anna; Steinmüller-Nethl, Doris; Krueger, Anke; Costea, Daniela Elena; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-03)
      The aim is to evaluate the effect of modifying poly[(l-lactide)-co-(ε-caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or with nDP+physisorbed BMP-2 (nDP+BMP-2) on in vivo host tissue response and degradation. The ...

    • Inflammatory mediators in saliva and gingival fluid of children with congenital heart defect 

      Mohamed Ali, Hiba; Mustafa, Manal; Suliman, Salwa; Elshazali, Osama Hafiz; Ali, Raouf Wahab; Berggreen, Ellen (Journal article; Peer reviewed, 2020)
      Objectives (a) To compare levels of pro- and anti-inflammatory mediators in saliva and gingival crevicular fluid (GCF) in children with and without congenital heart defects (CHD cases and controls) and to test whether a ...

    • Influence of Bone Substitutes on Mesenchymal Stromal Cells in an Inflammatory Microenvironment 

      Shanbhag, Siddharth; Rana, Neha; Suliman, Salwa; Idris, Shaza Bushra Mohamed; Mustafa, Kamal Babikeir Elnour; Stavropoulos, Andreas (Journal article; Peer reviewed, 2022)
      Bone regeneration is driven by mesenchymal stromal cells (MSCs) via their interactions with immune cells, such as macrophages (MPs). Bone substitutes, e.g., bi-calcium phosphates (BCPs), are commonly used to treat bone ...

    • Influence of platelet storage time on human platelet lysates and platelet lysate-expanded mesenchymal stromal cells for bone tissue engineering 

      Shanbhag, Siddharth; Mohamed Ahmed, Samih; Lunde, Turid Helen Felli; Suliman, Salwa; Bolstad, Anne Isine; Hervig, Tor; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2020)
      Background Human platelet lysate (HPL) is emerging as the preferred xeno-free supplement for the expansion of mesenchymal stromal cells (MSCs) for bone tissue engineering (BTE) applications. Due to a growing demand, the ...

    • Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes 

      Suliman, Salwa; Mustafa, Kamal Babikeir Eln; Krueger, Anke; Steinmüller-Nethl, Doris; Finne-Wistrand, Anna; Osdal, Tereza; Osman, Amani Hamza Ali; Sun, Yang; Parajuli, Himalaya; Waag, Thilo; Nickel, Joachim; Johannessen, Anne Christine; McCormack, Emmet; Costea, Daniela Elena (Peer reviewed; Journal article, 2016-07)
      This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance ...

    • Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo 

      Suliman, Salwa; Xing, Zhe; Wu, X; Xue, Ying; Pedersen, Torbjørn Østvik; Sun, Y; Døskeland, Anne Marie Simonne; Nickel, Joachim; Waag, Thilo; Lygre, Henning; Finne Wistrand, Anna; Steinmüller-Nethl, Doris; Krueger, Anke; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2015-01-10)
      A low dose of 1 μg rhBMP-2 was immobilised by four different functionalising techniques on recently developed poly(l-lactide)-co-(ε-caprolactone) [(poly(LLA-co-CL)] scaffolds. It was either (i) physisorbed on unmodified ...

    • RvE1 Impacts the Gingival Inflammatory Infiltrate by Inhibiting the T Cell Response in Experimental Periodontitis 

      Alvarez, Carla; Abdalla, Henrique; Suliman, Salwa; Rojas, Paola; Wu, Yu-Chiao; Almarhoumi, Rawan; Huang, Ren-Yeong; Galindo, Mario; Vernal, Rolando; Kantarci, Alpdogan (Journal article; Peer reviewed, 2021)
      Periodontitis is a chronic inflammatory disease associated with the formation of dysbiotic plaque biofilms and characterized by the progressive destruction of the alveolar bone. The transition from health to disease is ...

    • Spheroid Coculture of Human Gingiva-Derived Progenitor Cells With Endothelial Cells in Modified Platelet Lysate Hydrogels 

      Shanbhag, Siddharth; Elsebahy, Ahmad Rashad; Helgeland Nymark, Ellen; Suliman, Salwa; Davies, Catharina de Lange; Stavropoulos, Andreas; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021-08-26)
      Cell coculture strategies can promote angiogenesis within tissue engineering constructs. This study aimed to test the angiogenic potential of human umbilical vein endothelial cells (HUVEC) cocultured with gingiva-derived ...