Browsing Bergen Open Research Archive by Author "Sutinen, Aleksi"
Now showing items 1-6 of 6
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Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane
Sutinen, Aleksi; Jones, Nykola C.; Hoffmann, Søren Vrønning; Ruskamo, Salla; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)The mitochondrial outer membrane creates a diffusion barrier between the cytosol and the mitochondrial intermembrane space, allowing the exchange of metabolic products, important for efficient mitochondrial function in ... -
Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability
Sutinen, Aleksi; Paffenholz, Dirk; Nguyen, Giang Thi Tuyet; Ruskamo, Salla; Torda, Andrew E.; Kursula, Petri Tapani (Journal article; Peer reviewed, 2023)Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its subtypes are linked to mutations in dozens of different genes, including the gene coding for ganglioside-induced ... -
Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc
Godoy Munoz, Jose Miguel; Neset, Lasse; Markusson, Sigurbjörn; Weber, Sarah; Krokengen, Oda Caspara; Sutinen, Aleksi; Christakou, Eleni; Lopez, Andrea J.; Bramham, Clive Raymond Evjen; Kursula, Petri Tapani (Journal article; Peer reviewed, 2024)The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and ... -
Structural insights into Charcot–Marie–Tooth disease-linked mutations in human GDAP1
Sutinen, Aleksi; Nguyen, Giang Thi Tuyet; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Ylikallio, Emil; Tyynismaa, Henna; Bartesaghi, Luca; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2022)Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its different subtypes are linked to mutations in dozens of different genes. Mutations in ganglioside-induced ... -
Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations
Nguyen, Giang Thi Tuyet; Sutinen, Aleksi; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri (Journal article; Peer reviewed, 2021)Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders. Despite the common involvement of ganglioside-induced differentiation-associated protein 1 (GDAP1) in CMT, the protein structure ... -
Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
Myllykoski, Matti; Sutinen, Aleksi; Koski, M. Kristian; Kallio, Juha Pekka; Raasakka, Arne; Myllyharju, Johanna; Wierenga, Rik K.; Koivunen, Peppi (Journal article; Peer reviewed, 2021)Prolyl 4-hydroxylases (P4Hs) catalyze post-translational hydroxylation of peptidyl proline residues. In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a third P4H—the poorly characterized endoplasmic ...