Blar i Bergen Open Research Archive på forfatter "Svarstad, Einar"
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Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss
Najafian, Behzad; Tøndel, Camilla; Svarstad, Einar; Gubler, Marie-Claire; Oliveira, Joao-Paulo; Mauer, Michael (Journal article; Peer reviewed, 2020)Background In males with classic Fabry disease, the processes leading to the frequent outcome of ESKD are poorly understood. Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) ... -
Addition of eGFR and age improves the prognostic absolute renal risk-model in 1,134 norwegian patients with IgA nephropathy
Knoop, Thomas; Vågane, Ann Merethe; Vikse, Bjørn Egil; Svarstad, Einar; Magnusdottir, Bergrun Tinna; Leh, Sabine Maria; Reisæter, Anna Varberg; Bjørneklett, Rune (Peer reviewed; Journal article, 2015-05)Background: Predicting outcome in individual patients with IgA nephropathy (IgAN) is difficult but important. For this purpose, the absolute renal risk (ARR) model has been developed in a French cohort to calculate the ... -
The changing landscape of Fabry disease
Svarstad, Einar; Marti, Hans-Peter (Journal article; Peer reviewed, 2020) -
Developing nephrology services in low income countries: A case of Tanzania
Furia, Francis F.; Shoo, Jacqueline; Ruggajo, Paschal Joseph; Kilonzo, Kajiru; Basu, Gopal; Yeates, Karen; Varughese, Santosh; Svarstad, Einar; Kisanga, Onesmo (Peer reviewed; Journal article, 2019-10-17)Background: The burden of kidney diseases is reported to be higher in lower- and middle-income countries as compared to developed countries, and countries in sub-Saharan Africa are reported to be most affected. Health ... -
Early indicators of disease progression in Fabry disease that may indicate the need for disease-specific treatment initiation: Findings from the opinion-based PREDICT-FD modified Delphi consensus initiative
Hughes, Derralynn A.; Aguiar, Patricio; Deegan, Patrick B; Ezgu, Fatih; Frustaci, Andrea; Lidove, Olivier; Linhart, Aleš; Lubanda, Jean-Claude; Moon, James C; Nicholls, Kathleen; Niu, Dau-Ming; Nowak, Albina; Ramaswami, Uma; Reisin, Ricardo; Rozenfeld, Paula; Schiffmann, Raphael; Svarstad, Einar; Thomas, Mark; Torra, Roser; Vujkovac, Bojan; Warnock, David G.; West, Michael L; Johnson, Jack; Rolfe, Mark J; Feriozzi, Sandro (Journal article; Peer reviewed, 2020)Objectives The PRoposing Early Disease Indicators for Clinical Tracking in Fabry Disease (PREDICT-FD) initiative aimed to reach consensus among a panel of global experts on early indicators of disease progression that may ... -
End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population
Skrunes, Rannveig; Svarstad, Einar; Reisæter, Anna Varberg; Marti, Hans-Petter; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2016-11-09)Background: Increased risk of end stage renal disease (ESRD) and death in Norwegian living kidney donors has been reported, most of the donors were related to the recipient. The present study investigates risk of death in ... -
Low birth weight and risk of progression to end stage renal disease in IgA nephropathy - A retrospective registry-based cohort study
Ruggajo, Paschal Joseph; Svarstad, Einar; Leh, Sabine Maria; Marti, Hans-Peter; Reisæter, Anna Varberg; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2016-04-19)Background: Low Birth Weight (LBW) is a surrogate for fetal undernutrition and is associated with impaired nephron development in utero. In this study, we investigate whether having been born LBW and/or small for gestational ... -
Mosaicism of podocyte involvement is related to podocyte injury in females with Fabry disease
Mauer, Michael; Glynn, Emily; Svarstad, Einar; Tøndel, Camilla; Gubler, Marie-Claire; West, Michael; Sokolovskiy, Alexey; Whitley, Chester; Najafian, Behzad (Peer reviewed; Journal article, 2014-11-11)Background: Fabry disease. an X-linked deficiency of α-galactosidase A coded by the GLA gene, leads to intracellular globotriaosylceramide (GL-3) accumulation. Although less common than in males, chronic kidney disease, ... -
Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document
Biegstraaten, Marieke; Arngrímsson, R; Barbey, F; Boks, L; Cecchi, Franco; Deegan, PB; Feldt-Rasmussen, Ulla; Geberhiwot, T; Germain, DP; Hendriksz, C; Hughes, DA; Kantola, I; Karabul, N; Lavery, C; Linthorst, GE; Mehta, A; van de Mheen, E; Oliveira, JP; Parini, R; Ramaswami, Uma; Rudnicki, M; Serra, A; Sommer, Claudia; Sunder-Plassmann, G; Svarstad, Einar; Sweeb, A; Terryn, W; Tylki-Szymanska, A; Tøndel, Camilla; Vujkovac, B; Weidemann, Frank; Wijburg, FA; Woolfson, P; Hollak, CE. (Peer reviewed; Journal article, 2015-05-27)Introduction Fabry disease (FD) is a lysosomal storage disorder resulting in progressive nervous system, kidney and heart disease. Enzyme replacement therapy (ERT) may halt or attenuate disease progression. Since administration ...