Browsing Bergen Open Research Archive by Author "Svingen, Gard Frodahl Tveitevåg"
Now showing items 1-20 of 26
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Association of body mass index with risk of acute myocardial infarction and mortality in Norwegian male and female patients with suspected stable angina pectoris: a prospective cohort study
Borgeraas, Heidi; Hertel, Jens Kristoffer; Svingen, Gard Frodahl Tveitevåg; Seifert, Reinhard; Pedersen, Eva Kristine Ringdal; Schartum-Hansen, Hall; Hjelmesæth, Jøran; Nygård, Ottar (Peer reviewed; Journal article, 2014-05-21)Background: A number of previous studies have suggested that overweight or obese patients with coronary artery disease (CAD) may have lower morbidity and mortality than their leaner counterparts. Few studies have addressed ... -
B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris
Ding, Yunpeng; Pedersen, Eva Ringdal; Johansson, Stefan; Gregory III, Jesse F.; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Helgeland, Øyvind; Meyer, Klaus; Fredriksen, Åse; Nygård, Ottar (Peer reviewed; Journal article, 2016-06)Background: Methylenetetrahydrofolate dehydrogenase (MTHFD1) catalyzes three sequential reactions that metabolize derivatives of tetrahydrofolate (THF) in folate-dependent one-carbon metabolism. Impaired MTHFD1 flux has ... -
B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Bjørnestad, Espen Øglænd; Ulvik, Arve; Saeed, Sahrai; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background Calcium channel blockers (CCBs) are used for the treatment of cardiovascular disease (CVD), including angina pectoris, and hypertension; however, the effect on survival remains uncertain. CCBs impair fibrinolysis ... -
Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease
Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Ørn, Stein; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for ... -
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease
Bjørnestad, Espen Ø.; Olset, Hilde; Dhar, Indu; Løland, Kjetil Halvorsen; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Svardal, Asbjørn M.; Berge, Rolf K; Ueland, Per Magne; Tell, Grethe S.; Nilsen, Dennis W.T.; Jan E., Nordrehaug; Nygaard, Ellisif; Nygård, Ottar (Journal article; Peer reviewed, 2020)Background The carnitine precursor trimethyllysine (TML) is associated with progression of atherosclerosis, possibly through a relationship with trimethylamine-N-oxide (TMAO). Riboflavin is a cofactor in TMAO synthesis. ... -
Components of the choline oxidation pathway in relation to acute myocardial infarction, type 2 diabetes and mortality. Prospective observational studies among patients with suspected or verified coronary heart disease in Norway
Svingen, Gard Frodahl Tveitevåg (Doctoral thesis, 2016-04-07)BACKGROUND. The choline oxidation pathway comprises the sequential metabolism of choline into betaine, dimethylglycine (DMG), and sarcosine. In addition, dietary choline and betaine can be turned into trimethylamine N-amino ... -
Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease
Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2019-09-09)Purpose: We hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery ... -
Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study
Strand, Elin; Pedersen, Eva Kristine Ringdal; Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Rebnord, Eirik Wilberg; Bjørndal, Bodil; Seifert, Reinhard; Bohov, Pavol; Meyer, Klaus; Hiltunen, J. Kalervo; Nordrehaug, Jan Erik; Nilsen, Dennis W. T.; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2013-10-08)Background: A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence ... -
Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease
Dhar, Indu; Lysne, Vegard; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Gregory, Jesse F.; Bønaa, Kaare Harald; Nygård, Ottar (Journal article; Peer reviewed, 2019)Background Elevated circulating cystathionine levels are related to atherosclerotic cardiovascular disease, a leading cause of death globally. Objective We investigated whether plasma cystathionine was associated with ... -
Even chained acylcarnitines predict long-term cardiovascular prognosis in patients with chest pain and non-obstructive coronary artery disease
Storesund, Silje Kjellevold; Karaji, Iman; Strand, Elin; Svardal, Asbjørn M.; Lønnebakken, Mai Tone; Berge, Rolf Kristian; Svingen, Gard Frodahl Tveitevåg; Nygård, Ottar Kjell; Pedersen, Eva Ringdal (Journal article; Peer reviewed, 2022)Background Acylcarnitines are essential for mitochondrial fatty acid oxidation. Earlier studies suggest that impaired energy metabolism may be implicated in the pathogenesis of microvascular angina. We explored metabolites ... -
Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: A prospective cohort study
Rebnord, Eirik Wilberg; Pedersen, Eva Kristine Ringdal; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Meyer, Klaus; Schartum-Hansen, Hall; Løland, Kjetil Halvorsen; Seifert, Reinhard; Ueland, Per Magne; Nilsen, Dennis W. T.; Nordrehaug, Jan Erik; Nygård, Ottar (Peer reviewed; Journal article, 2015-05)Objective: Associations of glycated hemoglobin A1c (HbA1c) levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear. We investigated relations of HbA1c to ... -
Neopterin as an effect modifier of the cardiovascular risk predicted by total homocysteine: A prospective 2-cohort study
Bjørnestad, Espen Øglænd; Borsholm, Robert Andre; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Seifert, Reinhard; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S.; Bønaa, Kaare Harald; Nygård, Ottar (Peer reviewed; Journal article, 2017-10)Background: Plasma total homocysteine (tHcy) is related to plasma neopterin, an indicator of interferon‐γ‐mediated immune activation, and both biomarkers positively predict cardiovascular risk. We examined whether the ... -
Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats
Lysne, Vegard; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Bjørndal, Bodil; Pedersen, Eva Ringdal; Midttun, Øivind; Olsen, Thomas; Ueland, Per Magne; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2016-01-05)Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be ... -
Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Ulvik, Arve; Bjørnestad, Espen Øglænd; Dankel, Simon N; Mellgren, Gunnar; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2022)Background Physical activity (PA) influences sympathetic stimulation, platelet activation as well as vascular function, and has been associated with improved health outcomes in patients with coronary heart disease. β-blocker ... -
Plasma 25-hydroxyvitamin D and mortality in patients with suspected stable angina pectoris
Degerud, Eirik; Nygård, Ottar; De Vogel, Stefan; Hoff, Rune; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Dierkes, Jutta (Peer reviewed; Journal article, 2018-03)Context and Objective: Vitamin D status may affect cardiovascular disease (CVD) development and survival. We studied the relationship between concentrations of the circulating biomarker 25-hydroxyvitamin D (25OHD) and ... -
Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles
Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal; Ulvik, Arve; Meyer, Klaus; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Bønaa, Kaare; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac ... -
Plasma cystathionine and risk of incident stroke in patients with suspected stable angina pectoris
Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Lysne, Vegard; Svenningsson, Mads Malm; Tell, Grethe S.; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background: Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6‐dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, ... -
Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris
Ding, Yunpeng; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Gregory, Jesse F.; Ueland, Per Magne; Tell, Grethe Seppola; Nygård, Ottar (Peer reviewed; Journal article, 2015)Background Glycine is an amino acid involved in antioxidative reactions, purine synthesis, and collagen formation. Several studies demonstrate inverse associations of glycine with obesity, hypertension, and diabetes mellitus. ... -
Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study
Dhar, Indu; Lysne, Vegard; Ulvik, Arve; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Bjørnestad, Espen Øglænd; Olsen, Thomas; Borsholm, Robert Andre; Laupsa-Borge, Johnny; Ueland, Per Magne; Tell, Grethe Seppola; Berge, Rolf Kristian; Mellgren, Gunnar; Bønaa, Kaare Harald; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and is considered a marker of vitamin B12 deficiency. Moreover, MMA-dependent reactions have been ... -
The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A
Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Dhar, Indu; Tell, Grethe S.; Blomhoff, Rune; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background. Plasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease, but the mechanisms remain unclear. Vitamin A (Vit-A) is involved in homocysteine metabolism and we therefore ...