• Association of chronic heart failure with mortality in old intensive care patients suffering from Covid-19 

      Bruno, Raphael Romano; Wernly, Bernhard; Wolff, Georg; Fjølner, Jesper; Artigas, Antonio; Bollen Pinto, Bernardo; Schefold, Joerg C.; Kindgen-Milles, Detlef; Baldia, Philipp Heinrich; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Topeli, Arzu; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Kondili, Eumorfia; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Jung, Christian (Journal article; Peer reviewed, 2022)
      Aims Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes ...
    • The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19 

      Bruno, Raphael Romano; Wernly, Bernhard; Flaatten, Hans Kristian; Fjølner, Jesper; Artigas, Antonio; Baldia, Philipp Heinrich; Binneboessel, Stephan; Bollen Pinto, Bernardo; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Kondili, Eumorfia; Marsh, Brian; Wollborn, Jakob; Andersen, Finn Husøy; Moreno, Emilio Ruiz; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Jung, Christian (Journal article; Peer reviewed, 2022)
      Purpose Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities ...
    • The Clinical Frailty Scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data 

      Bruno, Raphael Romano; Wernly, Bernhard; Bagshaw, Sean M.; van den Boogaard, Mark; Darvall, Jai N.; De Geer, Lina; de Gopegui Miguelena, Pablo Ruiz; Heyland, Daren K.; Hewitt, David; Hope, Aluko A.; Langlais, Emilie; Le Maguet, Pascale; Montgomery, Carmel L.; Papageorgiou, Dimitrios; Seguin, Philippe; Geense, Wytske W.; Silva-Obregón, J. Alberto; Wolff, Georg; Polzin, Amin; Dannenberg, Lisa; Kelm, Malte; Flaatten, Hans Kristian; Beil, Michael; Franz, Marcus; Sviri, Sigal; Leaver, Susannah; Guidet, Bertrand; Boumendil, Ariane; Jung, Christian (Journal article; Peer reviewed, 2023)
      Background This large-scale analysis pools individual data about the Clinical Frailty Scale (CFS) to predict outcome in the intensive care unit (ICU). Methods A systematic search identified all clinical trials that ...
    • Differences in mortality in critically ill elderly patients during the second COVID‑19 surge in Europe 

      Jung, Christian; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolf, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Andersen, Finn H.; Moreno, Rui; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans (Journal article; Peer reviewed, 2021)
      Background: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. Methods: This was a prospective European ...
    • Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation 

      Jung, Christian; Mamandipoor, Behrooz; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter V.; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Osmani, Venet (Journal article; Peer reviewed, 2022)
      Background:The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ...
    • Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years 

      Soliman, Ivo W; Leaver, Susannah; Flaatten, Hans Kristian; Fjølner, Jesper; Wernly, Bernhard; Bruno, Raphael R; Artigas, Antonio; Bollen Pinto, Bernardo; Schefold, Joerg C; Beil, Michael; Sviri, Sigal; Van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Wollborn, Jakob; Banzo, Maria Jose Arche; Fuest, Kristina; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Boumendil, Ariane; Guidet, Bertrand; Jung, Christian; De Lange, Dylan W (Journal article; Peer reviewed, 2022)
      Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. Objective to ...
    • The impact of age-related syndromes on ICU process and outcomes in very old patients 

      Vallet, Hélène; Guidet, Bertrand; Boumendil, Ariane; De Lange, Dylan W.; Leaver, Susannah; Szczeklik, Wojciech; Jung, Christian; Sviri, Sigal; Beil, Michael; Flaatten, Hans Kristian (Journal article; Peer reviewed, 2023)
      In this narrative review, we describe the most important age-related “syndromes” found in the old ICU patients. The syndromes are frailty, comorbidity, cognitive decline, malnutrition, sarcopenia, loss of functional autonomy, ...
    • The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study 

      Jung, Christian; Flaatten, Hans; Fjølner, Jesper; Romano Bruno, Raphael; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand (Journal article; Peer reviewed, 2021)
      Background The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in ...
    • Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study 

      Polok, Kamil; Fronczek, Jakub; Artigas, Antonio; Flaatten, Hans Kristian; Guidet, Bertrand; De Lange, Dylan W.; Fjølner, Jesper; Leaver, Susannah; Beil, Michael; Sviri, Sigal; Bruno, Raphael Romano; Wernly, Bernhard; Bollen Pinto, Bernardo; Schefold, Joerg C.; Studzińska, Dorota; Joannidis, Michael; Oeyen, Sandra; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Jung, Christian; Szczeklik, Wojciech (Journal article; Peer reviewed, 2022)
      Background Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. ...
    • Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic 

      Polok, Kamil; Fronczek, Jakub; Guidet, Bertrand; Artigas, Antonio; De Lange, Dylan W.; Fjølner, Jesper; Leaver, Susannah; Beil, Michael; Sviri, Sigal; Bruno, Raphael Romano; Wernly, Bernhard; Pinto, Bernardo Bollen; Schefold, Joerg C.; Studzińska, Dorota; Joannidis, Michael; Oeyen, Sandra; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Flaatten, Hans Kristian; Jung, Christian; Szczeklik, Wojciech (Journal article; Peer reviewed, 2023)
      Background Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and ...
    • Who gets the ventilator? A multicentre survey of intensivists' opinions of triage during the first wave of the COVID-19 pandemic 

      Fjølner, Jesper; Haaland, Øystein Ariansen; Jung, Christian; de Lange, Dylan W.; Szczeklik, Wojciech; Leaver, Susannah; Guidet, Bertrand; Sviri, Sigal; Van Heerden, Peter Vernon; Beil, Michael; Hartog, Christiane S.; Flaatten, Hans Kristian (Journal article; Peer reviewed, 2022)
      Background The COVID-19 pandemic has caused a shortage of intensive care resources. Intensivists' opinion of triage and ventilator allocation during the COVID-19 pandemic is not well described. Methods This was a ...