Blar i Bergen Open Research Archive på forfatter "Tenstad, Olav"

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    • Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat 

      Mullins, Linda; Ivy, Jessica; Ward, Mairi; Tenstad, Olav; Wiig, Helge; Kitada, Kento; Manning, Jon; Rakova, Natalia; Müller, Dominik; Mullins, John (Journal article; Peer reviewed, 2021)
      We discovered high Na+ and water content in the skin of newborn Sprague–Dawley rats, which reduced ~ 2.5-fold by 7 days of age, indicating rapid changes in extracellular volume (ECV). Equivalent changes in ECV post birth ...

    • CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model 

      Kleinmanns, Katrin; Fosse, Vibeke Samuelsen; Davidson, Ben; de Jalón, Elvira Garcia; Tenstad, Olav; Bjørge, Line; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      Background The completeness of resection is a key prognostic indicator in patients with ovarian cancer, and the application of tumour-targeted fluorescence image-guided surgery (FIGS) has led to improved detection of ...

    • The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation 

      Malmgren, Linnea; Öberg, Carl; den Bakker, Emil; Leion, Felicia; Siódmiak, Joanna; Åkesson, Anna; Lindström, Veronica; Herou, Erik; Dardashti, Alain; Xhakollari, Liana; Grubb, Gabriel; Strevens, Helena; Abrahamson, Magnus; Helmersson-Karlqvist, Johanna; Magnusson, Martin; Björk, Jonas; Nyman, Ulf; Ärnlöv, Johan; Ridefeldt, Peter; Åkerfeldt, Torbjörn; Hansson, Magnus; Sjöström, Anna; Mårtensson, Johan; Itoh, Yoshihisa; Grubb, David; Tenstad, Olav; Hansson, Lars-Olov; Olafsson, Isleifur; Campos, Araceli Jarquin; Risch, Martin; Risch, Lorenz; Larsson, Anders; Nordin, Gunnar; Pottel, Hans; Christensson, Anders; Bjursten, Henrik; Bökenkamp, Arend; Grubb, Anders (Journal article; Peer reviewed, 2022)
      Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)-markers creatinine or cystatin C. A recommendation to use both markers in parallel ...

    • Effect of Topical Anaesthetics on Interstitial Colloid Osmotic Pressure in Human Subcutaneous Tissue Sampled by Wick Technique 

      Guthe, Hans Jørgen Timm; Nedrebø, Torbjørn; Tenstad, Olav; Wiig, Helge; Berg, Ansgar (Peer reviewed; Journal article, 2012-02-14)
      Objectives: To measure colloid osmotic pressure in interstitial fluid (COPi) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. ...

    • Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions 

      Åsrud, Kathrine Sivertsen; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Pedersen, Line; van der Hoeven, Barbara; Karlsen, Tine Veronica; Rygh, Cecilie Brekke; Curry, Fitz-Roy; Bakke, Marit; Reed, Rolf K.; Tenstad, Olav; Døskeland, Stein Ove (Journal article; Peer reviewed, 2020)
      Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting ...

    • High-salt diet causes osmotic gradients and hyperosmolality in skin without affecting interstitial fluid and lymph 

      Nikpey Esfahlan, Elham; Karlsen, Tine Veronica; Rakova, Natalia; Titze, Jens M.; Tenstad, Olav; Wiig, Helge (Peer reviewed; Journal article, 2017-04)
      The common notion is that the body Na+ is maintained within narrow limits for fluid and blood pressure homeostasis. Several studies have, however, shown that considerable amounts of Na+ can be retained or removed from the ...

    • Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice 

      Brekke, Cecilie; Løkka, Guro; Heljäsvaara, Ritva; Taxt, Torfinn; Pavlin, Tina; Sormunen, Raija T.; Pihlajaniemi, Taina; Curry, Fitz-Roy E.; Tenstad, Olav; Reed, Rolf K. (Peer reviewed; Journal article, 2014-01)
      Collagen XV and XVIII are ubiquitous constituents of basement membranes. We aimed to study the physiological roles of these two components of the permeability barrier non-invasively in striated muscle in mice deficient in ...

    • Increased microvascular permeability in mice lacking Epac1 (Rapgef3) 

      Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; Kristiansen, K.; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove (Peer reviewed; Journal article, 2017-02)
      Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ...

    • Interstitial changes in spleen during sepsis 

      Svendsen, Øyvind Sverre; Stangeland, Lodve; Elvevoll, Bjørg; Gjertsen, Bjørn Tore; Skavland, Jørn; Wiig, Helge; Tenstad, Olav; Husby, Paul (Conference poster, 2014-09-26)

    • Interstitial fluid drainage from rat apical area takes place via vessels in the mandibular canal. 

      Virtej, Anca; Tenstad, Olav; Wiig, Helge; Berggreen, Ellen (Journal article; Peer reviewed, 2020)
      We sought to investigate the transport route for protein‐rich fluid from the apical area towards the draining lymph nodes. The first mandibular molar root canals in 24 female Wistar rats were instrumented and filled with ...

    • Interstitial fluid: the overlooked component of the tumor microenvironment? 

      Wiig, Helge; Tenstad, Olav; Iversen, Per Ole; Kalluri, Raghu; Bjerkvig, Rolf (Peer reviewed; Journal article, 2010-07-23)
      Background: The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the ...

    • Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches 

      Eigenmann, Miro Julian; Karlsen, Tine Veronica; Krippendorff, Ben-Fillippo; Tenstad, Olav; Fronton, Ludivine; Otteneder, Michael B.; Wiig, Helge (Peer reviewed; Journal article, 2017-12)
      For most therapeutic antibodies, the interstitium is the target space. Although experimental methods for measuring antibody pharmacokinetics (PK) in this space are not well established, thus making quantitative assessment ...

    • Na+ is shifted from the extracellular to the intracellular compartment and is not inactivated by glycosaminoglycans during high salt conditions in rats 

      Thowsen, Irene Matre; Karlsen, Tine Veronica; Nikpey, Elham; Haslene-Hox, Hanne; Skogstrand, Trude; Randolph, Gwendalyn J.; Zinselmeyer, Bernd H.; Tenstad, Olav; Wiig, Helge (Journal article; Peer reviewed, 2022)
      Recently, studies have emerged suggesting that the skin plays a role as major Na+ reservoir via regulation of the content of glycosaminoglycans and osmotic gradients. We investigated whether there were electrolyte gradients ...

    • A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue 

      Haslene-Hox, Hanne; Oveland, Eystein; Berg, Kaja Christine Graue; Kolmannskog, Odd; Woie, Kathrine; Salvesen, Helga Birgitte; Tenstad, Olav; Wiig, Helge (Peer reviewed; Journal article, 2011-04-26)
      Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ...

    • Novel clearance of muscle proteins by muscle cells 

      Muslimovic, Aida; Friden, Vincent; Starnberg, Karin; Tenstad, Olav; Espedal, Heidi; Vukusic, Kristina; Nyström, Susanne; Wesén, Emelie; Esbjörner, Elin K; Granholm, Kristoffer; Lindahl, Bertil; Hammarsten, Ola (Journal article; Peer reviewed, 2020)
      Blood levels of cardiac troponins (cTn) and myoglobin are analysed when myocardial infarction (MI) is suspected. Here we describe a novel clearance mechanism for muscle proteins by muscle cells. The complete plasma clearance ...

    • Pharmacokinetics and pharmacodynamics of t-cell bispecifics in the tumour interstitial fluid 

      Eigenmann, Miro Julian; Karlsen, Tine Veronica; Wagner, Marek; Tenstad, Olav; Weinzierl, Tina; Fauti, Tanja; Grimm, Hans Peter; Skogstrand, Trude; Klein, Christian; Sam, Johannes; Umana, Pablo; Bacac, Marina; Wiig, Helge; Walz, Antje-Christine (Journal article; Peer reviewed, 2021)
      The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent ...

    • Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease 

      Khramova, Alina; Boi, Roberto; Fridén, Vincent; Granqvist, Anna Björnson; Nilsson, Ulf; Tenstad, Olav; Oveland, Eystein; Haraldsson, Börje; Ebefors, Kerstin; Nyström, Jenny (Journal article; Peer reviewed, 2021)
      All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ...

    • Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats 

      Finne, Kenneth; Vethe, Heidrun; Skogstrand, Trude; Leh, Sabine Maria; Dahl, Tone Dolva; Tenstad, Olav; Berven, Frode S.; Reed, Rolf K.; Vikse, Bjørn Egil (Peer reviewed; Journal article, 2014-08-16)
      Background It is well known that hypertension may cause glomerular damage, but the molecular mechanisms involved are still incompletely understood. Methods In the present study, we used formalin-fixed paraffin-embedded ...

    • Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood 

      Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga Birgitte; Wiig, Helge; Tenstad, Olav (Peer reviewed; Journal article, 2014-12)
      Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ...

    • VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats 

      Samuelsson, Anne-Maj; Bartolomaeus, Theda Ulrike Patricia; Anandakumar, Harithaa; Thowsen, Irene Matre; Nikpey, Elham; Han, Jianhua; Marko, Lajos; Finne, Kenneth; Tenstad, Olav; Eckstein, Johannes; Berndt, Nikolaus; Kühne, Titus; Kedziora, Sarah; Sultan, Ibrahim; Skogstrand, Trude; Karlsen, Tine Veronica; Nurmi, Harri; Forslund, Sofia K.; Bollano, Entela; Alitalo, Kari; Muller, Dominik N.; Wiig, Helge (Journal article; Peer reviewed, 2023)
      Aims: Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial ...