Browsing Bergen Open Research Archive by Author "Toker, Lilah"
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Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition
Sanchez Nido, Gonzalo; Dick, Fiona; Toker, Lilah; Petersen, Kjell; Alves, Guido Werner; Tysnes, Ole-Bjørn; Jonassen, Inge; Haugarvoll, Kristoffer; Tzoulis, Charalampos (Journal article; Peer reviewed, 2020-04-21)The etiology of Parkinson’s disease is largely unknown. Genome-wide transcriptomic studies in bulk brain tissue have identified several molecular signatures associated with the disease. While these studies have the potential ... -
Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain
Toker, Lilah; Tran, Gia T.; Sundaresan, Janani; Tysnes, Ole-Bjørn; Alves, Guido; Haugarvoll, Kristoffer; Nido, Gonzalo S.; Dölle, Christian; Tzoulis, Charalampos (Journal article; Peer reviewed, 2021)Background: Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic ... -
A nationwide study of the incidence, prevalence and mortality of Parkinson’s disease in the Norwegian population
Brakedal, Brage; Toker, Lilah; Haugarvoll, Kristoffer; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)Epidemiological studies of Parkinson’s disease (PD) show variable and partially conflicting findings with regard to incidence, prevalence, and mortality. These differences are commonly attributed to technical and methodological ...