• Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID‑19 

      Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Stiksrud, Birgitte; Berge, Tone; Barratt-Due, Andreas; Aukrust, Pål; Heggelund, Lars; Blennow, Kaj; Zetterberg, Henrik; Harbo, Hanne Flinstad; Quist‑Paulsen, Else (Journal article; Peer reviewed, 2021)
      Objective To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for ...
    • Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the ISARIC WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study 

      Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan J.C.; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan Ahmad; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, François; Bekken, Gry Klouman; Dudman, Susanne Gjeruldsen; Dyrhol-Riise, Anne Ma; Heggelund, Lars; Hesstvedt, Liv; Holten, Aleksander Rygh; Holter, Jan Cato; Jenum, Synne; Johal, Simreen Kaur; Lind, Andreas; Müller, Fredrik; Muller, Karl Erik; Pettersen, Frank O.; Quist-Paulsen, Else; Reikvam, Dag Henrik; Skeie, Linda Gail; Skogen, Vegard; Stiksrud, Birgitte; Tonby, Kristian (Journal article; Peer reviewed, 2022)
      Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained ...
    • The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection 

      Tonby, Kristian; Wergeland, Ida; Lieske, Nora Valeska; Kvale, Dag; Tasken, Kjetil; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2016-10-24)
      Background: Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. ...
    • Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice 

      Mortensen, Rasmus; Clemmensen, Helena Strand; Woodworth, Joshua S.; Therkelsen, Marie Louise; Mustafa, Tehmina; Tonby, Kristian; Jenum, Synne; Agger, Else Marie; Dyrhol-Riise, Anne Ma; Andersen, Peter (Peer reviewed; Journal article, 2019)
      Tuberculosis, caused by infection with Mycobacterium tuberculosis (Mtb), kills over 1.6 million people each year despite availability of antibiotics. The increase in drug resistant Mtb strains is a major public health ...
    • Dyspnea, lung function and CT findings three months after hospital admission for COVID-19 

      Lerum, Tøri Vigeland; Aaløkken, Trond M; Brønstad, Eivind; Aarli, Bernt Bøgvald; Ikdahl, Eirik; Lund, Kristine Marie Aarberg; Durheim, Michael; Rivero, Jezabel Rodriguez; Meltzer, Carin; Tonby, Kristian; Stavem, Knut; Skjønsberg, Ole Henning; Ashraf, Haseem; Einvik, Gunnar (Journal article; Peer reviewed, 2021)
      The long-term pulmonary outcomes of coronavirus disease 2019 (COVID-19) are unknown. We aimed to describe self-reported dyspnoea, quality of life, pulmonary function and chest computed tomography (CT) findings 3 months ...
    • Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 

      Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian; Pischke, Soeren; Jenum, Synne; Skeie, Linda Gail; Nur, Sarah; Lind, Andreas; Opsand, Hanne; Enersen, Tone Burvald; Grøndahl, Ragnhild; Hermann, Anne; Dudman, Susanne Gjeruldsen; Müller, Fredrik; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma (Journal article; Peer reviewed, 2020-12)
      In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and ...
    • IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy 

      Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2015-04)
      Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ...
    • Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...
    • A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients 

      Jenum, Synne; Tonby, Kristian; Rueegg, Corina Silvia; Ruhwald, Morten; Kristiansen, Max Per; Bang, Peter; Olsen, Inge Christoffer; Sellæg, Kjersti; Røstad, Kjerstin; Mustafa, Tehmina; Tasken, Kjetil; Kvale, Dag; Mortensen, Rasmus; Riise, Anne Margarita Dyrhol (Journal article; Peer reviewed, 2021)
      Host-directed-therapy strategies are warranted to fight tuberculosis. Here we assess the safety and immunogenicity of adjunctive vaccination with the H56:IC31 candidate and cyclooxygenase-2-inhibitor treatment (etoricoxib) ...
    • Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients 

      Holter, Jan Cato; Pischke, Soeren; de Boer, Eline; Lind, Andreas; Jenum, Synne; Holten, Aleksander Rygh; Tonby, Kristian; Barratt-Due, Andreas; Sokolova, Marina; Schjalm, Camilla; Chaban, Viktoriia; Kolderup, Anette; Tran, Trung; Tollefsrud Gjølberg, Torleif; Skeie, Linda Gail; Hesstvedt, Liv; Ormåsen, Vidar; Fevang, Børre; Austad, Cathrine; Muller, Karl Erik; Fladeby, Cathrine; Holberg-Petersen, Mona; Halvorsen, Bente; Müller, Fredrik; Aukrust, Pål; Dudman, Susanne Gjeruldsen; Ueland, Thor; Andersen, Jan Terje; Lund-Johansen, Fridtjof; Heggelund, Lars; Dyrhol-Riise, Anne Ma; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2020)
      Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective ...