Blar i Bergen Open Research Archive på forfatter "Totland, Christian"
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9-Acridinemethanamine and Acridine-9-Carboxaldehyde as Potential Fluorescence Lifetime pH Indicators
Totland, Christian; Thomas, Peter; Holst, Bodil; Akhtar, Naureen; Hovdenes, Jostein; Skodvin, Tore (Journal article; Peer reviewed, 2020)A significant challenge concerning the development of fluorescence lifetime (FL) based pH sensors is the paucity of fluorophores with sufficiently large FL variation with pH. Acridine is amongst the indicators with highest ... -
Bioactive Metabolites of Marine Origin Have Unusual Effects on Model Membrane Systems
Jakubec, Martin; Totland, Christian; Rise, Frode; Chamgordani, Elahe Jafari; Paulsen, Britt; Maes, Louis; Matheeussen, An; Gundersen, Lise-Lotte; Halskau, Øyvind (Journal article; Peer reviewed, 2020)Marine sponges and soft corals have yielded novel compounds with antineoplastic and antimicrobial activities. Their mechanisms of action are poorly understood, and in most cases, little relevant experimental evidence is ... -
Effects and location of coplanar and noncoplanar PCB in a lipid bilayer: a solid-state NMR study
Totland, Christian; Nerdal, Willy; Steinkopf, Signe Lilia (Peer reviewed; Journal article, 2016-07-05)Coplanar and noncoplanar polychlorinated biphenyls (PCBs) are known to have different routes and degree of toxicity. Here, the effects of noncoplanar PCB 52 and coplanar PCB 77 present at 2 mol % in a model system consisting ... -
GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production
Mahootchi, Elaheh; Homaei, Selina Cannon; Kleppe, Rune; Winge, Ingeborg; Hegvik, Tor-Arne; Perez, Roberto Megias; Totland, Christian; Mogavero, Floriana; Baumann, Anne; Glennon, Jeffrey Colm; Miletic, Hrvoje; Kursula, Petri; Haavik, Jan (Journal article; Peer reviewed, 2020)Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neuromodulators. However, their biosynthetic routes and therapeutic potential are still being debated. This ... -
The use of surfactant-filled mesoporous silica as an immobilising medium for a fluorescence lifetime pH indicator, providing long-term calibration stability
Totland, Christian; Thomas, Peter; Holst, Bodil; Hovdenes, Jostein; Akhtar, Naureen; Skodvin, Tore (Peer reviewed; Journal article, 2019-11-14)Surfactant filled mesoporous silica is applied as a matrix for immobilizing the fluorescence lifetime pH-indicator acridine. We demonstrate that this type of encapsulation provides a stable and uniform chemical environment ...