• Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 

      Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2019)
      Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, virally ...
    • Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...
    • Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Rupp, Christian; Bergquist, Annika; Voitl, Robert; Folseraas, Trine; Trøseid, Marius; Midttun, Øivind; Ueland, Per Magne; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Kummen, Martin; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background and aims Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio ...
    • Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals 

      Hovland, Anders; Nestvold, Torunn Kristin; Bohov, Pavol; Trøseid, Marius; Aukrust, Pål; Berge, Rolf Kristian; Nielsen, Erik Waage; Retterstøl, Kjetil; Lappegård, Knut Tore (Peer reviewed; Journal article, 2017)
      Background: Obesity is a global pandemic leading to increased mortality and increased risk of cardiovascular disease. Bariatric surgery is an established treatment of obesity leading to weight loss and reduction of mortality. ...
    • The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection 

      Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M.; Hov, Johannes Espolin Roksund; Andreassen, Arne K.; Gude, Einar; Karason, Kristjan; Dellgren, Gøran; Berge, Rolf Kristian; Gullestad, Lars; Aukrust, Pål; Ueland, Thor (Peer reviewed; Journal article, 2019)
      BACKGROUND: Alterations in the partly microbiota-dependent carnitine–γ-butyrobetaine (γBB)–trimethylamine N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated ...
    • Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia; Moum, Bjørn; Vesterhus, Mette; Karlsen, Tom Hemming; Seljeflot, Ingebjørg; Hov, Johannes Espolin Roksund (Peer reviewed; Journal article, 2019-02)
      Background & Aims: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. We aimed to investigate whether ...
    • Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement 

      Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor; Michelsen, Annika; Otterdal, Kari; Muller, Karl Erik; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma; Holter, Jan Cato; Trøseid, Marius (Journal article; Peer reviewed, 2021)
      Background A high proportion of COVID‐19 patients have cardiac involvement, even those without known cardiac disease. Downregulation of angiotensin converting enzyme 2 (ACE2), a receptor for SARS‐CoV‐2 and the renin‐angiotensin ...
    • Gut microbiota-dependent trimethylamine N-oxide associates with inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Hov, Johannes Espolin Roksund; Ueland, Thor; Dahl, Tuva Børresdatter; Kummen, Martin; Otterdal, Kari; Holm, Kristian; Berge, Rolf Kristian; Mollnes, Tom Eirik; Trøseid, Marius; Halvorsen, Bente; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2020)
      A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications of unknown etiology. We have previously shown that systemic inflammation in CVID correlates ...
    • High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19 

      Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet; Lerum, Tøri Vigeland; Kaarbø, Mari; Heggelund, Lars; Holten, Aleksander Rygh; Finbråten, Ane-Kristine; Muller, Karl Erik; Mathiessen, Alexander; Bøe, Simen; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Lind, Andreas; Dudman, Susanne; Nezvalova-Henriksen, Katerina; Müller, Fredrik; Skjønsberg, Ole Henning; Trøseid, Marius; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but ...
    • HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation 

      Hove-Skovsgaard, Malene; Gaardbo, Julie Christine; Kolte, Lilian; Winding, Kamilla; Seljeflot, Ingebjørg; Svardal, Asbjørn M.; Berge, Rolf Kristian; Gerstoft, Jan; Ullum, Henrik; Trøseid, Marius; Nielsen, Susanne Dam (Peer reviewed; Journal article, 2017-03-29)
      Background: Increased incidence of cardiovascular diseases (CVD) in both HIV infection and type 2 diabetes (T2D) compared to the general population has been described. Little is known about the combined effect of HIV ...
    • Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial 

      Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (Peer reviewed; Journal article, 2017-05-02)
      Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ...
    • Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction 

      Hoel, Hedda Benedicte; Hove-Skovsgaard, Malene; Hov, Johannes Espolin Roksund; Gaardbo, Julie Christine; Holm, Kristian; Kummen, Martin; Rudi, Knut; Nwosu, Felix; Valeur, Jørgen; Gelpi, Marco; Seljeflot, Ingebjørg; Ueland, Per Magne; Gerstoft, Jan; Ullum, Henrik; Aukrust, Pål; Nielsen, Susanne Dam; Trøseid, Marius (Peer reviewed; Journal article, 2018-04-30)
      HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition ...
    • Low fibre intake is associated with gut microbiota alterations in chronic heart failure 

      Mayerhofer, Cristiane C.K.; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale; Vestad, Beate; Larsen, Christopher Storm; Seljeflot, Ingebjørg; Ueland, Thor; Bohov, Pavol; Berge, Rolf Kristian; Svardal, Asbjørn M.; Gullestad, Lars; Yndestad, Arne; Aukrust, Pål; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Peer reviewed, 2020)
      Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ...
    • Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery 

      Trøseid, Marius; Hov, Johannes Espolin Roksund; Nestvold, Torunn Kristin; Thoresen, Hanne; Berge, Rolf Kristian; Svardal, Asbjørn M.; Lappegård, Knut Tore (Journal article; Peer reviewed, 2016)
      Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of ...
    • Persistent pulmonary pathology after COVID‑19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase‑9 

      Lerum, Tøri Vigeland; Maltzahn, Niklas; Aukrust, Pål; Trøseid, Marius; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Dyrhol-Riise, Anne Ma; Stiksrud, Birgitte; Haugli, Mette; Blomberg, Bjørn; Kittang, Bård Reiakvam; Johannessen, Asgeir; Hannula, Raisa; Aballi, Saad; Kildal, Anders Benjamin; Eiken, Ragnhild; Dahl, Tuva Børresdatter; Lund-Johansen, Fridtjof; Müller, Fredrik; Rivero, Jezabel Rodriguez; Meltzer, Carin; Einvik, Gunnar; Ueland, Thor; Olsen, Inge Christoffer; Barratt-Due, Andreas; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning (Journal article; Peer reviewed, 2021)
      The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), ...
    • Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies 

      Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen; Yang, Kuan; Quiles Jimenez, Ana Maria Teresa; Heggelund, Lars; Muller, Karl Erik; Tveita, Anders Aune; Michelsen, Annika Elisabet; Bøe, Simen; Holten, Aleksander Rygh; Hoel, Hedda Benedicte; Mathiessen, Alexander; Aaløkken, Trond Mogens; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Nezvalova-Henriksen, Katerina; Lerum, Tøri Vigeland; Müller, Fredrik; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. Objectives: To investigate ...
    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)
      Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ...
    • Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial 

      Awoyemi, Ayodeji Olawale; Mayerhofer, Cristiane; Felix, Alex S.; Hov, Johannes Espolin Roksund; Moscavitch, Samuel D.; Lappegård, Knut Tore; Hovland, Anders; Halvorsen, Sigrun; Halvorsen, Bente; Gregersen, Ida; Svardal, Asbjørn M.; Berge, Rolf Kristian; Hansen, Simen Hyll; Götz, Alexandra; Holm, Kristian; Aukrust, Pål; Åkra, Sissel; Seljeflot, Ingebjørg; Solheim, Svein; Lorenzo, Andrea; Gullestad, Lars; Trøseid, Marius; Broch, Kaspar (Journal article; Peer reviewed, 2021)
      Background The gut microbiota represents a potential treatment target in heart failure (HF) through microbial metabolites such as trimethylamine N-oxide (TMAO) and systemic inflammation. Treatment with the probiotic yeast ...
    • Rosuvastatin alters the genetic composition of the human gut microbiome 

      Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur; Trøseid, Marius; Vestad, Beate; Skårdal, Rita; Yndestad, Arne; Ueland, Thor; Svardal, Asbjørn M.; Berge, Rolf Kristian; Seljeflot, Ingebjørg; Gullestad, Lars; Karlsen, Tom Hemming; Aaberge, Lars; Aukrust, Pål; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2020)
      The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the ...
    • Soluble Markers of the Toll-Like Receptor 4 Pathway Differentiate between Active and Latent Tuberculosis and Are Associated with Treatment Responses 

      Feruglio, Siri; Trøseid, Marius; Damås, Jan Kristian; Kvale, Dag; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2013-07-16)
      Background. Biomarkers to differentiate between active tuberculosis (TB) and latent TB infection (LTBI) and to monitor treatment responses are requested to complement TB diagnostics and control, particularly in patients ...