Blar i Bergen Open Research Archive på forfatter "Tromp, Jasper"

Viser treff 1-6 av 6

    • Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction 

      Savarese, Gianluigi; Uijl, Alicia; Ouwerkerk, Wouter; Tromp, Jasper; Anker, Stefan D.; Dickstein, Kenneth; Hage, Camilla; Lam, Carolyn S.P.; Lang, Chim C.; Metra, Marco; Ng, Leong L.; Orsini, Nicola; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Cleland, John G.F.; Voors, Adriaan A.; Lund, Lars H. (Journal article; Peer reviewed, 2022)
      Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early-phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent ...

    • Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D 

      Baumhove, Lukas; Bomer, Nils; Tromp, Jasper; van Essen, Bart J.; Dickstein, Kenneth; Cleland, John G.; Lang, Chim C.; Ng, Leong L.; Samani, Nilesh J.; Anker, Stefan D.; Metra, Marco; van Veldhuisen, Dirk J.; van der Meer, Peter; Voors, Adriaan A. (Journal article; Peer reviewed, 2023)
      Aims Heart failure (HF) is associated with cytokine activation and inflammation. Experimental evidence suggests that plasma interleukin-17 (IL-17) is associated with myocardial fibrosis and cardiac dysfunction in HF. ...

    • Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction 

      Woolley, Rebecca J.; Ceelen, Daan; Ouwerkerk, Wouter; Tromp, Jasper; Figarska, Sylwia M.; Anker, Stefan D.; Dickstein, Kenneth; Filippatos, Gerasimos; Zannad, Faiez; Marco, Metra; Ng, Leong L.; Samani, Nilesh J.; van Veldhuisen, Dirk J; Lang, Chim C.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of patients with HFpEF. We aimed to identify distinct pathophysiologic ...

    • Multimarker profiling identifies protective and harmful immune processes in heart failure: Findings from BIOSTAT-CHF 

      Markousis-Mavrogenis, George; Tromp, Jasper; Ouwerkerk, Wouter; Ferreira, João Pedro; Anker, Stefan D; Cleland, John G; Dickstein, Kenneth; Filippatos, Gerasimos; Lang, Chim C; Metra, Marco; Samani, Nilesh J; De Boer, Rudolf A; Van Veldhuisen, Dirk J; Voors, Adriaan A; Van Der Meer, Peter (Journal article; Peer reviewed, 2022)
      Aims The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to ...

    • Multimorbidity in patients with acute heart failure across world regions and country income levels (REPORT-HF): a prospective, multicentre, global cohort study 

      Gerhardt, Teresa; Gerhardt, Louisa M S; Ouwerkerk, Wouter; Roth, Gregory A; dickstein, kenneth; Collins, Sean P; Cleland, John G F; Dahlstrom, Ulf; Tay, Wan Ting; Ertl, Georg; Hassanein, Mahmoud; Perrone, Sergio V; Ghadanfar, Mathieu; Schweizer, Anja; Obergfell, Achim; Filippatos, Gerasimos; Lam, Carolyn S P; Tromp, Jasper; Angermann, Christiane E (Journal article; Peer reviewed, 2023)
      Background Multimorbidity (two or more comorbidities) is common among patients with acute heart failure, but comprehensive global information on its prevalence and clinical consequences across different world regions ...

    • Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure 

      Ceelen, Daan; Voors, Adriaan A.; Tromp, Jasper; van Veldhuisen, Dirk J.; Dickstein, Kenneth; de Boer, Rudolf A.; Lang, Chim C.; Anker, Stefan D.; Ng, Leong L.; Metra, Marco; Ponikowski, Piotr; Figarska, Sylwia M. (Journal article; Peer reviewed, 2022)
      Aims Elevated concentrations of growth differentiation factor 15 (GDF-15) in patients with heart failure (HF) have been consistently associated with worse clinical outcomes, but what disease mechanisms high GDF-15 ...