Blar i Bergen Open Research Archive på forfatter "Tronstad, Karl Johan"
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Activity monitoring and patient-reported outcome measures in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients
Rekeland, Ingrid Gurvin; Sørland, Kari; Bruland, Ove; Risa, Kristin; Alme, Kine; Dahl, Olav; Tronstad, Karl Johan; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2022-09-19)Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with no validated specific and sensitive biomarker, and no standard approved treatment. In this observational study with no intervention, ... -
Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties
Nikolaisen, Julie; Nilsson, Linn Iren Hodneland; Pettersen, Ina Katrine Nitschke; Willems, Peter H. G. M.; Lorens, James B.; Koopman, Werner J. H.; Tronstad, Karl Johan (Peer reviewed; Journal article, 2014-07-02)Mitochondrial morphology and function are coupled in healthy cells, during pathological conditions and (adaptation to) endogenous and exogenous stress. In this sense mitochondrial shape can range from small globular ... -
Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model
Hoel, August; Osman, Tarig; Hoel, Fredrik; Elsaid, Hassan Osman Alhassan; Chen, Tony; Landolt, Lea Zoe; Babickova, Janka; Tronstad, Karl Johan; Lorens, James B.; Gausdal, Gro; Marti, Hans-Peter; Furriol, Jessica (Journal article; Peer reviewed, 2021)Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ... -
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC
Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit; Helwa, Reham; Tan, Tuan Zea; Lotsberg, Maria Lie; Pettersen, Ina Katrine Nitschke; Berg, Anna; Kindt, Charlotte; Hoel, Fredrik; Jacobsen, Kristine; Arason, Ari Jon; Engelsen, Agnete; Ditzel, Henrik J.; Lønning, Per Eystein; Krakstad, Camilla; Thiery, Jean Paul; Lorens, James; Knappskog, Stian; Tronstad, Karl Johan (Peer reviewed; Journal article, 2019-06-01)Background: Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ... -
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
Svendsen, Agnete; Verhoeff, Joost J. C.; Immervoll, Heike; Brøgger, Jan C.; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger A.; Planagumà, Jesús; Torsvik, Anja; Sakariassen, Per Øystein; Bjerkvig, Rolf; Enger, Per Øyvind; Tronstad, Karl Johan (Peer reviewed; Journal article, 2011-08-24)Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ... -
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
Watson, Dionysios C.; Bayik, Defne; Storevik, Simon Humberto; Moreino, Shannon Sherwin; Sprowls, Samuel A.; Han, Jianhua; Augustsson, Mina Thue; Lauko, Adam; Sravya, Palavalasa; Røsland, Gro Vatne; Troike, Katie; Tronstad, Karl Johan; Wang, Sabrina; Sarnow, Katharina; Kay, Kristen; Lunavat, Taral; Silver, Daniel J.; Dayal, Sahil; Vareecal Joseph, Justin; Mulkearns-Hubert, Erin; Ystaas, Lars Andreas Rømo; Deshpande, Gauravi; Guyon, Joris; Zhou, Yadi; Magaut, Capucine R.; Seder, Juliana; Neises, Laura; Williford, Sarah E.; Meiser, Johannes; Scott, Andrew J.; Sajjakulnukit, Peter; Mears, Jason A.; Bjerkvig, Rolf; Chakraborty, Abhishek; Daubon, Thomas; Cheng, Feixiong; Lyssiotis, Costas A.; Wahl, Daniel R.; Hjelmeland, Anita B.; Hossain, Md Jubayer al; Miletic, Hrvoje; Lathia, Justin D. (Journal article; Peer reviewed, 2023)The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly ... -
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma
Moen, Ingrid; Tronstad, Karl Johan; Kolmannskog, Odd; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2009-12-17)Background: Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and ... -
Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model
Moen, Ingrid; Øyan, Anne Margrete; Kalland, Karl-Henning; Tronstad, Karl Johan; Akslen, Lars A.; Chekenya, Martha; Sakariassen, Per Øystein; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Peer reviewed; Journal article, 2009-07-28)Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-be ... -
Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)
Hagland, Hanne; Hodneland, Linn I.; Burri, Lena; Nikolaisen, Julie; Berge, Rolf Kristian; Tronstad, Karl Johan (Peer reviewed; Journal article, 2013-01)The hypolipidemic effect of peroxisome proliferator-activated receptor (PPAR) activators has been explained by increasing mitochondrial fatty acid oxidation, as observed in livers of rats treated with the pan-PPAR activator ... -
Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
Sundstrøm, Terje; Prestegarden, Lars; Azuaje, Francisco; Aasen, Synnøve Nymark; Røsland, Gro Vatne; Varughese, Jobin K.; Bahador, Marzieh; Bernatz, Simon; Braun, Yannick; Harter, Patrick N.; Skaftnesmo, Kai Ove; Ingham, Elizabeth S.; Mahakian, Lisa M.; Tam, Sarah; Tepper, Clifford G.; Petersen, Kjell; Ferrara, Katherine W.; Tronstad, Karl Johan; Lund-Johansen, Morten; Beschorner, Rudi; Bjerkvig, Rolf; Thorsen, Frits (Peer reviewed; Journal article, 2019-04-10)Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ... -
Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study
Rekeland, Ingrid Gurvin; Fosså, Alexander; Lande, Asgeir; Ktoridou-Valen, Irini; Sørland, Kari; Holsen, Mari; Tronstad, Karl Johan; Risa, Kristin; Alme, Kine; Viken, Marte Katrine; Lie, Benedicte Alexandra; Dahl, Olav; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2020)Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with high symptom burden, of unknown etiology, with no established treatment. We observed patients with long-standing ME/CFS who got ... -
A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Hoel, Fredrik; Hoel, August; Pettersen, Ina Katrine Nitschke; Rekeland, Ingrid Gurvin; Risa, Kristin; Alme, Kine; Sørland, Kari; Fosså, Alexander; Lien, Katarina; Herder, Ingrid; Thurmer, Hanne; Gotaas, Merethe Otelie Eide; Schäfer, Christoph; Berge, Rolf K.; Sommerfelt, Kristian; Marti, Hans Peter; Dahl, Olav; Mella, Olav; Fluge, Øystein; Tronstad, Karl Johan (Journal article; Peer reviewed, 2021)Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic ... -
Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
Fosså, Alexander; Smeland, Knut Bjøro; Fluge, Øystein; Tronstad, Karl Johan; Loge, Jon Håvard; Midtun, Øyvind; Ueland, Per Magne; Kiserud, Cecilie E. (Journal article; Peer reviewed, 2020)Chronic cancer-related fatigue (CF) is a common and distressing condition in a subset of cancer survivors and common also after successful treatment of malignant lymphoma. The etiology and pathogenesis of CF is unknown, ... -
Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
Tidwell, Tia R.; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland (Journal article; Peer reviewed, 2022)Background Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative of in vivo tumor conditions. To overcome the ... -
Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells
Alhourani, Abdelnour H.; Tidwell, Tia R.; Bokil, Ansooya Avinash; Røsland, Gro V.; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne R. (Journal article; Peer reviewed, 2021)Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. However, metabolic drug targeting is considered an underutilized and poorly understood area of cancer therapy. Metformin, a ... -
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.
Walter, Jonas; Bolognin, Silvia; Antony, Paul M.A.; Nickels, Sarah L.; Poovathingal, Suresh K.; Salamanca, Luis; Magni, Stefano; Perfeito, Rita; Hoel, Fredrik; Qing, Xiaobin; Jarazo, Javier; Arias-Fuenzalida, Jonathan; Ignac, Tomasz; Monzel, Anna S.; Gonzalez-Cano, Laura; Pereira de Almeida, Luis; Skupin, Alexander; Tronstad, Karl Johan; Schwamborn, Jens C. (Peer reviewed; Journal article, 2019-04-11)Summary Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a ... -
A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology
Hodneland, Linn I.; Pettersen, Ina Katrine Nitschke; Nikolaisen, Julie; Micklem, David Robert; Dale, Hege Avsnes; Røsland, Gro Vatne; Lorens, James; Tronstad, Karl Johan (Peer reviewed; Journal article, 2015-11-24)Changes in mitochondrial amount and shape are intimately linked to maintenance of cell homeostasis via adaptation of vital functions. Here, we developed a new live-cell reporter strategy to simultaneously monitor mitochondrial ... -
The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
Walter, Jonas; Bolognin, Silvia; Poovathingal, Suresh K.; Magni, Stefano; Gérard, Deborah; Antony, Paul M. A.; Nickels, Sarah L.; Salamanca, Luis; Berger, Emanuel; Smits, Lisa M.; Grzyb, Kamil; Perfeito, Rita; Hoel, Fredrik; Qing, Xiaobing; Ohnmacht, Jochen; Bertacchi, Michele; Jarazo, Javier; Ignac, Tomasz; Monzel, Anna S.; Gonzalez-Cano, Laura; Krüger, Rejko; Sauter, Thomas; Studer, Michèle; Pereira de Almeida, Luis; Tronstad, Karl Johan; Sinkkonen, Lasse; Skupin, Alexander; Schwamborn, Jens C. (Journal article; Peer reviewed, 2021)Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in ... -
Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
Larrieu, Claire M.; Storevik, Simon Humberto; Guyon, Joris; Pagano Zottola, Antonio C.; Bouchez, Cyrielle L.; Derieppe, Marie-Alix; Tan, Tuan Zea; Miletic, Hrvoje; Lorens, James; Tronstad, Karl Johan; Daubon, Thomas; Røsland, Gro Vatne (Journal article; Peer reviewed, 2022)Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12–15 months. In addition to highly proliferative and invasive properties, GB cells show ...