• Clinical and molecular effects of guanylate cyclase C-activation 

      Tronstad, Rune Rose (Doctoral thesis, 2019-06-06)
      We studied a large Norwegian family who had been affected by chronic diarrhoea and other symptoms from the digestive tract throughout several generations. Our genetic studies showed that family members with diarrhoea shared ...
    • Plasma levels of guanylins are reduced in patients with Crohn’s disease 

      Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Tronstad, Rune Rose; Dizdar, Vernesa; Nylund, Kim; Hanevik, Kurt; Hausken, Trygve; Gilja, Odd Helge; Fiskerstrand, Torunn (Journal article; Peer reviewed, 2020)
      Background: Guanylin (GN) and uroguanylin (UGN) are endogenous ligands for the intestinal receptor guanylate cyclase C (GC-C), an important regulator of intestinal fluid homeostasis. Gene expression and protein levels of ...
    • Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation 

      Volkmann, Hilde Løland Von; Brønstad, Ingeborg; Gilja, Odd Helge; Tronstad, Rune Rose; Sangnes, Dag André; Nortvedt, Ragnar; Hausken, Trygve; Dimcevski, Georg Gjorgji; Fiskerstrand, Torunn; Nylund, Kim (Peer reviewed; Journal article, 2017)
      Introduction: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C ...