• Addition of IMP3 to L1CAM for discrimination between low- and high-grade endometrial carcinomas: a European Network for Individualised Treatment of Endometrial Cancer collaboration study 

      Visser, Nicole C.M.; van der Putten, Louis J.M.; van Egerschot, Alex; van de Vijver, Koen K.; Santacana, Maria; Bronsert, Peter; Hirschfeld, Marc; Colas, Eva; Gil-Moreno, Antonio; Garcia, Angel; Mancebo, Gemma; Alameda, Francesc; Krakstad, Camilla; Tangen, Ingvild Løberg; Huvila, Jutta; Schrauwen, Stefanie; Koskas, Martin; Walker, Francine; Weinberger, Vit; Minar, Lubos; Hausnerova, Jitka; Snijders, Marc P.L.M.; van den Berg-van Erp, Saskia; Matias-Guiu, Xavier; Trovik, Jone; Amant, Frédéric; Massuger, Leon F.A.G.; Bulten, Johan; Pijnenborg, Johanna M.A. (Peer reviewed; Journal article, 2019)
      Discrimination between low- and high-grade endometrial carcinomas (ECs) is clinically relevant but can be challenging for pathologists, with moderate interobserver agreement. Insulin-like growth factor-II mRNA-binding ...
    • Androgen receptor as potential therapeutic target in metastatic endometrial cancer 

      Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin; Berg, Anna; Halle, Mari Kyllesø; Øyan, Anne Margrete; Werner, Henrica Maria Johanna; Trovik, Jone; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2016-06-30)
      Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ...
    • Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival 

      Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø; Berg, Anna; Haugland, Hans Kristian; Øyan, Anne Margrete; Kalland, Karl-Henning; Stefansson, Ingunn Marie; Akslen, Lars A.; Krakstad, Camilla; Trovik, Jone; Werner, Henrica Maria Johanna; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2017)
      Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard ...
    • Association Between Proportion of Nuclei With High Chromatin Entropy and Prognosis in Gynecological Cancers 

      Nielsen, Birgitte; Kleppe, Andreas; Hveem, Tarjei Sveinsgjerd; Pradhan, Manohar; Syvertsen, Rolf Anders; Nesheim, John Arne; Kristensen, Gunnar S Balle; Trovik, Jone; Kerr, David J.; Albregtsen, Fritz; Danielsen, Håvard Emil (Peer reviewed; Journal article, 2018-04-18)
      Background: Nuclear texture analysis measuring differences in chromatin structure has provided prognostic biomarkers in several cancers. There is a need for improved cell-by-cell chromatin analysis to detect nuclei with ...
    • ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma 

      Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Halle, Mari Kyllesø; Berg, Anna; Werner, Henrica Maria Johanna; Ræder, Maria B.; Kusonmano, Kanthida; Zou, June; Øyan, Anne Margrete; Stefansson, Ingunn; Trovik, Jone; Kalland, Karl-Henning; Chen, Hong-Wu; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2015)
      We have explored the potential for clinical implementation of ATAD2 as a biomarker for aggressive endometrial cancer by investigating to what extent immunohistochemical (IHC) staining for ATAD2 is feasible, reflects clinical ...
    • Blood Metabolites Associate with Prognosis in Endometrial Cancer 

      Strand, Elin; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Jacob, Havjin; Halle, Mari Kyllesø; Hoivik, Erling A; Delvoux, Bert; Trovik, Jone; Haldorsen, Ingfrid S.; Romano, Andrea; Krakstad, Camilla (Peer reviewed; Journal article, 2019-12-14)
      Endometrial cancer has a high prevalence among post-menopausal women in developed countries. We aimed to explore whether certain metabolic patterns could be related to the characteristics of aggressive disease and poorer ...
    • Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling 

      Forsse, David Erik; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Viste, Kristin; Almås, Bjørg; Bertelsen, Bjørn-Erik; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla (Peer reviewed; Journal article, 2020-02)
      Objective Blood-based biomarkers are attractive due to ease of sampling and standardized measurement technology, reducing obstacles to clinical implementation. The objective of this study was to evaluate a clinically ...
    • Cancer awareness in the general population varies with sex, age and media coverage: A population-based survey with focus on gynecologic cancers 

      Fonnes, Tina; Telle, Ingrid Ovidia Moe; Forsse, David Erik; Falck, Runa; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla (Journal article; Peer reviewed, 2021)
      Objectives There is a need for more knowledge about the public awareness and attitudes towards gynecologic cancers. We employed a research-purpose population-based citizen panel to assess how often people recall gynecologic ...
    • Candidate locus analysis of the TERT–CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk 

      Carvajal-Carmona, Luis G.; O'Mara, Tracy A.; Painter, Jodie N.; Lose, Felicity A.; Dennis, Joe; Michailidou, Kyriaki; Tyrer, Jonathan P; Ahmed, Shahana; Ferguson, Kaltin; Healey, Catherine S.; Pooley, Karen; Beesley, Jonathan; Cheng, Timothy; Jones, Angela; Howarth, Kimberley; Martin, Lynn; Gorman, Maggie; Hodgson, Shirley; Wentzensen, Nicholas; Fasching, Peter A.; Hein, Alexander; Beckmann, Matthias W.; Renner, Stefan P.; Dörk, Thilo; Hillemanns, Peter; Durst, Matthias; Runnebaum, Ingo; Lambrechts, Dieter; Coenegrachts, Lieve; Schrauwen, Stefanie; Amant, Frederic; Winterhoff, Boris; Dowdy, Sean C.; Goode, Ellen L.; Teoman, Attila; Salvesen, Helga Birgitte; Trovik, Jone; Njølstad, Tormund Salvesen; Werner, Henrica Maria Johanna; Scott, Rodney J.; Ashton, Katie; Proietto, Tony; Otton, Geoffrey; Wersäll, Ofra; Mints, Miriam; Tham, Emma; Hall, Per; Czene, Kamila; Liu, Jianjun; Li, Jingmei; Hopper, John L.; Southey, Melissa C.; Ekici, Arif B.; Ruebner, Matthias; Johnson, Nichola; Peto, Julian; Burwinkel, Barbara; Marme, Frederik; Brenner, Hermann; Dieffenbach, Aida Karina; Meindl, Alfons; Brauch, Hiltrud; Lindblom, Annika; Depreeuw, Jeroen; Moisse, Matthieu; Chang-Claude, Jenny; Rudolph, Anja; Couch, Fergus J.; Olson, Janet E.; Giles, Graham G.; Bruinsma, Fiona; Cunningham, Julie M.; Fridley, Brooke L.; Børresen-Dale, Anne-Lise; Kristensen, Vessela N.; Cox, Angela; Swerdlow, Anthony J.; Orr, Nicholas; Bolla, Manjeet K.; Wang, Qin; Weber, Rachel Palmieri; Chen, Zhihua; Shah, Mitul; Pharoah, Paul D.P.; Dunning, Alison M.; Tomlinson, Ian; Easton, Douglas F.; Spurdle, Amanda B.; Thompson, Deborah J. (Peer reviewed; Journal article, 2014-12-09)
      Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported with ...
    • Chromatin organisation and cancer prognosis: a pan-cancer study 

      Kleppe, Andreas; Albregtsen, Fritz; Vlatkovic, Ljiljana; Pradhan, Manohar; Nielsen, Birgitte; Hveem, Tarjei Sveinsgjerd; Askautrud, Hanne Arenberg; Kristensen, Gunnar S Balle; Nesbakken, Arild; Trovik, Jone; Wæhre, Haakon; Tomlinson, Ian; Shepherd, Neil A.; Novelli, Marco; Kerr, David J.; Danielsen, Håvard Emil (Peer reviewed; Journal article, 2018-03)
      Background: Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the ...
    • Coping with a disruptive life caused by obstetric fistula: Perspectives from Malawian women 

      Changole, Josephine; Combs Thorsen, Viva; Trovik, Jone; Kafulafula, Ursula; Sundby, Johanne (Peer reviewed; Journal article, 2019)
      Background: The main symptom of obstetric fistula is urinary and or fecal incontinence. Incontinence, regardless of the type is debilitating, socially isolating, and psychologically depressing. The objective of this study ...
    • Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma 

      Berg, Hege Fredriksen; Ju, Zhenlin; Myrvold, Madeleine; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Høivik, Erling Andre; Westin, Shannon; Trovik, Jone; Haldorsen, Ingfrid S.; Mills, Gordon B.; Krakstad, Camilla; Werner, Henrica Maria Johanna (Journal article; Peer reviewed, 2020-02-10)
      Background In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed to develop models ...
    • DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer 

      Njølstad, Tormund Salvesen; Trovik, Jone; Hveem, Tarjei Sveinsgjerd; Kjæreng, Marna Lill; Kildal, Wanja; Pradhan, Manohar; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Haugland, Hans Kristian; Eraker, Runar; Oddenes, Klaus; Rokne, Jan Anders; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Werner, Henrica Maria Johanna; Salvesen, Helga Birgitte; Danielsen, Håvard Emil (Peer reviewed; Journal article, 2015-04-21)
      Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ...
    • Endometrial ablation; less is more? Historical cohort study comparing long-term outcomes from two time periods and two treatment modalities for 854 women 

      Helleland, Liva; Bergesen, Lena Flekke; Rinnan, Karen Jakobsen; Engelsen, Ingeborg Bøe; Hordnes, Knut; Trovik, Jone (Peer reviewed; Journal article, 2019-07-10)
      Background: Abnormal uterine bleeding needs surgical treatment if medical therapy fails. After introduction of non-hysteroscopic endometrial ablation as alternative to hysteroscopic endometrial resection, we aimed to compare ...
    • Endometrial carcinoma; can biomarkers aid in the prediction of aggressive disease? A study with focus on preoperative tumour markers 

      Trovik, Jone (Doctoral thesis, 2012-05-04)
      Background: Although endometrial cancer in general has a good prognosis, 15-20% recurs. Surgery is the main treatment with lymph node sampling increasingly advocated as compulsory for adequate staging. In metastatic disease, ...
    • Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymph node metastases and poor outcome in endometrial cancer patients 

      Tangen, Ingvild Løberg; Kopperud, Reidun Kristin; Visser, Nicole C.M.; Staff, Anne Cathrine; Tingulstad, Solveig; Marcickiewicz, Janusz; Amant, Frédéric; Bjørge, Line; Pijnenborg, Johanna M.A.; Salvesen, Helga; Werner, Henrica Maria Johanna; Trovik, Jone; Krakstad, Camilla (Peer reviewed; Journal article, 2017-09)
      Background: Several studies have identified L1 cell adhesion molecule (L1CAM) as a strong prognostic marker in endometrial cancer. To further underline the clinical usefulness of this biomarker, we investigated L1CAM as a ...
    • HER2 expression patterns in paired primary and metastatic endometrial cancer lesions 

      Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Berg, Hege Fredriksen; Hoivik, Erling A; Mauland, Karen Klepsland; Kusonmano, Kanthida; Berg, Anna; Hurtado, Antoni; Kalland, Karl-Henning; Øyan, Anne Margrete; Stefansson, Ingunn; Vintermyr, Olav Karsten; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Trovik, Jone; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2017-11-23)
      Background: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers ...
    • High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer 

      Mauland, Karen Klepsland; Trovik, Jone; Wik, Elisabeth; Ræder, Maria B.; Njølstad, Tormund Salvesen; Stefansson, Ingunn Marie; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjørge, Tone; Akslen, Lars A.; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2011)
      Background: Endometrial cancer incidence is increasing in industrialised countries. High body mass index (BMI, kg m−2) is associated with higher risk for disease. We wanted to investigate if BMI is related to clinico-pathological ...
    • High degree of heterogeneity of PD-L1 and PD-1 from primary to metastatic endometrial cancer 

      Engerud, Hilde Renate; Berg, Hege Fredriksen; Myrvold, Madeleine; Halle, Mari Kyllesø; Bjørge, Line; Haldorsen, Ingfrid S.; Høivik, Erling Andre; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2020)
      Objective PD-L1 and PD-1 are predictive markers for immunotherapy and increasingly relevant in endometrial cancer. The reported fraction of positive primary tumors has been inconsistent. We investigated the expression of ...
    • High visceral fat percentage is associated with poor outcome in endometrial cancer 

      Mauland, Karen Klepsland; Eng, Øyvin Andre Solberg; Ytre-Hauge, Sigmund; Tangen, Ingvild Løberg; Berg, Anna; Salvesen, Helga; Salvesen, Øyvind; Krakstad, Camilla; Trovik, Jone; Høivik, Erling Andre; Werner, Henrica Maria Johanna; Mellgren, Gunnar; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2017-10-19)
      Despite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution ...