Browsing Bergen Open Research Archive by Author "Turcu, Diana Cornelia"
Now showing items 1-9 of 9
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Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix
Bril'kov, Maxim; Dobrovolska, Olena; Ødegård-Fougner, Øyvind; Turcu, Diana Cornelia; Strømland, Øyvind; Underhaug, Jarl; Aasland, Rein; Halskau, Øyvind (Journal article; Peer reviewed, 2022-04-13)The CW domain binds to histone tail modifications found in different protein families involved in epigenetic regulation and chromatin remodeling. CW domains recognize the methylation state of the fourth lysine on histone ... -
Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization
Jakubec, Martin; Bariås, Espen; Furse, Samuel Robert; Govasli Larsen, Morten Andreas; George, Vinnit; Turcu, Diana Cornelia; Iashchishyn, Igor A.; Morozova-Roche, Ludmilla A.; Halskau, Øyvind (Journal article; Peer reviewed, 2021)Dysregulation of the biosynthesis of cholesterol and other lipids has been implicated in many neurological diseases, including Parkinson's disease. Misfolding of α-synuclein (α-Syn), the main actor in Parkinson's disease, ... -
Homeodomain transcription factors Six3 and Six6 have distinct protein binding characteristics
Turcu, Diana Cornelia (Doctoral thesis, 2015-02-20)The goal of this study was to characterize Six3 and Six6 proteins interactions and to better understand their functions. The Six class proteins are found in a wide variety of animals ranging from primitive invertebrate ... -
Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins
Gavgani, Fatemeh Mazloumi; Slinning, Malene Skuseth; Morovicz, Andrea Papdine; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; D'Santos, Clive S.; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)Polyphosphoinositides (PPIns) play essential roles as lipid signaling molecules, and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin ... -
Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells
Mazloumi Gavgani, Fatemeh; Karlsson, Thomas; Tangen, Ingvild Løberg; Papdine Morovicz, Andrea; Arnesen, Victoria Smith; Turcu, Diana Cornelia; Ninzima, Sandra; Spang, Katharina Maria; Krakstad, Camilla; Guillermet-Guibert, Julie; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2021)The class I phosphoinositide 3-kinase (PI3K) catalytic subunits p110α and p110β are ubiquitously expressed but differently targeted in tumours. In cancer, PIK3CB (encoding p110β) is seldom mutated compared with PIK3CA ... -
A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction
Karlsson, Thomas; Altankhuyag, Altanchimeg; Dobrovolska, Olena; Turcu, Diana Cornelia; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2016-07)Polyphosphoinositides (PPIns) are present in the nucleus where they participate in crucial nuclear processes, such as chromatin remodelling, transcription and mRNA processing. In a previous interactomics study, aimed to ... -
Resolving the zinc binding capacity of honey bee vitellogenin and locating its putative binding sites
Leipart, Vilde; Enger, Øyvind; Turcu, Diana Cornelia; Dobrovolska, Olena; Drabløs, Finn; Halskau, Øyvind; Amdam, Gro Vang (Journal article; Peer reviewed, 2022)The protein vitellogenin (Vg) plays a central role in lipid transportation in most egg-laying animals. High Vg levels correlate with stress resistance and lifespan potential in honey bees (Apis mellifera). Vg is the primary ... -
SIX3 and SIX6 interact with GEMININ via C-terminal regions
Turcu, Diana Cornelia; Lillehaug, Johan R.; Seo, Hee-Chan (Peer reviewed; Journal article, 2019-12)The histoarchitecture and function of eye and forebrain depend on a well-controlled balance between cell proliferation and differentiation. For example, the binding of the cell cycle regulator GEMININ to CDT1, which is a ... -
Structural dynamics of human deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase)
Sarre, Birta Ravdna Alexandersen; Dobrovolska, Olena; Lundström, Patrik; Turcu, Diana Cornelia; Agback, Tatiana; Halskau, Øyvind; Isaksson, Johan Mattias (Journal article; Peer reviewed, 2024)Structural- and functional heterogeneity, as well as allosteric regulation, in homo-monomeric enzymes is a highly active area of research. One such enzyme is human nuclear-associated deoxyuridine 5’-triphosphate ...