Browsing Bergen Open Research Archive by Author "Tvedt, Tor Henrik Anderson"
Now showing items 1-20 of 20
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The acute phase reaction and its prognostic impact in patients with head and neck squamous cell carcinoma: Single biomarkers including c-reactive protein versus biomarker profiles
Aarstad, Helene Hersvik; Moe, Svein Erik Emblem; Bruserud, Øystein; Lybak, Stein; Aarstad, Hans Jørgen; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2020)C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines ... -
The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile
Aarstad, Helene Hersvik; Gudbrandsdottir, Gigja; Hjelle, Karin; Bostad, Leif; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. ... -
Clonal heterogeneity reflected by pi3k-akt-mtor signaling in human acute myeloid leukemia cells and its association with adverse prognosis
Nepstad, Ina; Hatfield, Kimberley Joanne; Tvedt, Tor Henrik Anderson; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2018-09-14)Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin ... -
The complexity of targeting PI3K-Akt-mTOR signalling in human acute myeloid leukaemia: The importance of leukemic cell heterogeneity, neighbouring mesenchymal stem cells and immunocompetent cells
Brenner, Annette; Tvedt, Tor Henrik Anderson; Bruserud, Øystein (Peer reviewed; Journal article, 2016-11-11)Therapeutic targeting of PI3K-Akt-mTOR is considered a possible strategy in human acute myeloid leukaemia (AML); the most important rationale being the proapoptotic and antiproliferative effects of direct PI3K/mTOR inhibition ... -
The Constitutive Extracellular Protein Release by Acute Myeloid Leukemia Cells—A Proteomic Study of Patient Heterogeneity and Its Modulation by Mesenchymal Stromal Cells
Aasebø, Elise; Brenner, Annette; Birkeland, Even; Tvedt, Tor Henrik Anderson; Selheim, Frode; Berven, Frode Steingrimsen; Bruserud, Øystein (Journal article; Peer reviewed, 2021)Extracellular protein release is important both for the formation of extracellular matrix and for communication between cells. We investigated the extracellular protein release by in vitro cultured normal mesenchymal stem ... -
Cytokine release syndrome in the immunotherapy of hematological malignancies: The biology behind and possible clinical consequences
Tvedt, Tor Henrik Anderson; Vo, Anh Khoi; Bruserud, Øystein; Reikvam, Håkon (Journal article; Peer reviewed, 2021)Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, ... -
Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report
Trovik, Linn; Sandnes, Miriam; Blomberg, Bjørn; Holmaas, Gunhild; Ahmed, Aymen B.; Tvedt, Tor Henrik Anderson; Vintermyr, Olav Karsten; Reikvam, Håkon (Journal article; Peer reviewed, 2020)Background Hemophagocytic lymphohistiocytosis (HLH) is a rare heterogenous genetic or acquired hyperinflammatory syndrome associated with a high degree of morbidity and mortality. HLH has clinical manifestations related ... -
Immunological heterogeneity of healthy peripheral blood stem cell donors - Effects of granulocyte colony-stimulating factor on inflammatory responses
Tvedt, Tor Henrik Anderson; Melve, Guro Kristin; Tsykunova, Galina; Ahmed, Aymen B; Brenner, Annette; Bruserud, Øystein (Peer reviewed; Journal article, 2018-09-22)Interleukin-6 (IL-6) contributes to the development of immune-mediated complications after allogeneic stem cell transplantation. However, systemic IL-6 levels also increase during granulocyte colony-stimulating factor ... -
Immunomodulatory Drugs Alter the Metabolism and the Extracellular Release of Soluble Mediators by Normal Monocytes
Rundgren, Ida Marie; Ryningen, Anita; Tvedt, Tor Henrik Anderson; Bruserud, Øystein; Ersvær, Elisabeth (Journal article; Peer reviewed, 2020)Immunomodulatory drugs (IMiDs) are used in the treatment of hematological malignancies, especially multiple myeloma. IMiDs have direct anticancer effects but also indirect effects via cancer-supporting stromal cells. ... -
Interleukin-6 in allogeneic stem cell transplantation: Its possible importance for immunoregulation and as a therapeutic target
Tvedt, Tor Henrik Anderson; Ersvær, Elisabeth; Tveita, Anders; Bruserud, Øystein (Peer reviewed; Journal article, 2017-06-08)Allogeneic stem cell transplantation is associated with a high risk of treatment-related mortality mainly caused by infections and graft-versus-host disease (GVHD). GVHD is characterized by severe immune dysregulation and ... -
Monocytes from neonates and adults have a similar capacity to adapt their cytokine production after previous exposure to BCG and β-glucan
Namakula, Rhoda; de Bree, L Charlotte J; Tvedt, Tor Henrik Anderson; Netea, Mihai G; Cose, Stephen; Hanevik, Kurt (Journal article; Peer reviewed, 2020-02-21)The Bacillus Calmette-Guérin (BCG) vaccine is administered at birth in tuberculosis (TB) endemic countries. BCG vaccination is also associated with protective non-specific effects against non-tuberculous infections. This ... -
A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation
Tvedt, Tor Henrik Anderson; Hovland, Randi; Tsykunova, Galina; Ahmed, Aymen B; Gedde-Dahl, Thobias; Bruserud, Øyvind (Peer reviewed; Journal article, 2018-07)Interleukin (IL)‐6 is an important regulator of immunity and inflammation in many diseases. Single nucleotide polymorphisms (SNPs) in the IL‐6 gene influence outcome after allogeneic stem cell transplantation (ASCT), but ... -
Pneumomediastinum etter sternalpunksjon
Tvedt, Tor Henrik Anderson; Vetti, Nils; Bruserud, Øystein (Journal article; Peer reviewed, 2021) -
Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation.
Lindås, Roald; Tvedt, Tor Henrik Anderson; Hatfield, Kimberley Joanne; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2014-10-08)Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active ... -
The role of interleukin-6 classical and trans-signaling in allogeneic stem cell transplantation
Tvedt, Tor Henrik Anderson (Doctoral thesis, 2020-04-02)IL-6 family cytokines share structural similarities and utilize glycoprotein 130 (gp130) for signal transduction. IL-6 itself has both pro- and anti-inflammatory effects. IL-6 trans-signaling is mediated by the soluble ... -
Serum levels of the IL-6 family of cytokines predict prognosis in renal cell carcinoma (RCC)
Gudbrandsdottir, Gigja; Aarstad, Helene Hersvik; Bostad, Leif; Hjelle, Karin; Aarstad, Hans Jørgen; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)Purpose An improved understanding of RCC immunology should shed further light on RCC tumor biology. Our objective was to study to what extent serum levels of the IL-6 family of cytokines at diagnosis were relevant to ... -
Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis
Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Ahmed, Aymen B; Vintermyr, Olav Karsten; Hervig, Tor Audun; Guttormsen, Anne Berit; Reikvam, Håkon (Journal article; Peer reviewed, 2021)Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused ... -
Surgical Treatment of Severe Bowel Obstruction as a Rare Complication Following Allogenic Hematopoietic Stem Cell Transplantation
Reikvam, Håkon; Tvedt, Tor Henrik Anderson; Johansen, Silje; Setran, Hege Aase; Havre, Roald Flesland (Journal article, 2020)Gastrointestinal graft-versus-host disease (GVHD) and cytomegalovirus (CMV) disease are common complications occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and contribute to a high degree ... -
The systemic metabolic profile early after allogeneic stem cell transplantation: Effects of adequate energy support administered through enteral feeding tube
Tvedt, Tor Henrik Anderson; Skaarud, Kristin Aneta Joan; Tjønnfjord, Geir Erland; Gedde-Dahl, Tobias; Iversen, Per Ole; Bruserud, Øystein (Journal article; Peer reviewed, 2020)Patients undergoing allogeneic stem cell transplantation usually require nutritional support. There is no consensus on whether enteral support through tube feeding should be preferred. A recent randomized study could not ... -
Therapeutic use of valproic acid and all-trans retinoic acid in acute myeloid leukemia—literature review and discussion of possible use in relapse after allogeneic stem cell transplantation
Bruserud, Øystein; Tsykunova, Galina; Hernandez-Valladares, Maria; Reikvam, Håkon; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2021)Even though allogeneic stem cell transplantation is the most intensive treatment for acute myeloid leukemia (AML), chemo-resistant leukemia relapse is still one of the most common causes of death for these patients, as is ...