• Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 

      Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2019)
      Objective: To explore monocyte and dendritic cell immune responses, and their association with future CD4+ gain in treated HIV patients with suboptimal CD4+ recovery. Design: A cross-sectional study of HIV-infected, virally ...
    • Attenuated Notch signaling in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018-03-28)
      The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ...
    • The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection 

      Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M.; Hov, Johannes Espolin Roksund; Andreassen, Arne K.; Gude, Einar; Karason, Kristjan; Dellgren, Gøran; Berge, Rolf Kristian; Gullestad, Lars; Aukrust, Pål; Ueland, Thor (Peer reviewed; Journal article, 2019)
      BACKGROUND: Alterations in the partly microbiota-dependent carnitine–γ-butyrobetaine (γBB)–trimethylamine N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated ...
    • Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity 

      Berg, Åse; Patel, Sam; Gonca, Miguel; Catarina, David; Otterdal, Kari; Ueland, Thor; Dalen, Ingvild; Kvaløy, Jan Terje; Mollnes, Tom Eirik; Aukrust, Pål; Langeland, Nina (Peer reviewed; Journal article, 2014-12-11)
      Background Co-infection with malaria and HIV increases the severity and mortality of both diseases, but the cytokine responses related to this co-infection are only partially characterised. The aim of this study was to ...
    • Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Peer reviewed; Journal article, 2018)
      The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with ...
    • High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections 

      Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2018-11-23)
      Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces ...
    • The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure 

      Yndestad, Arne; Finsen, Alexandra Vanessa; Ueland, Thor; Husberg, Cathrine; Dahl, Christen P.; Dickstein, Kenneth (Peer reviewed; Journal article, 2012-03-12)
      Background: CCL19 and CCL21, acting through CCR7, are termed homeostatic chemokines. Based on their role in concerting immunological responses and their proposed involvement in tissue remodeling, we hypothesized that these ...
    • Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial 

      Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (Peer reviewed; Journal article, 2017-05-02)
      Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ...
    • Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency 

      Macpherson, Magnhild Eide; Halvorsen, Bente; Yndestad, Arne; Ueland, Thor; Mollnes, Tom Eirik; Berge, Rolf Kristian; Rashidi, Azita; Otterdal, Kari; Gregersen, Ida; Kong, Xiang Yi; Holven, Kirsten Bjørklund; Aukrust, Pål; Fevang, Børre; Jørgensen, Silje Fjellgård (Peer reviewed; Journal article, 2019-07-01)
      Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ...
    • Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19 

      Jørgensen, Marthe Jøntvedt; Holter, Jan Cato; Christensen, Erik; Schjalm, Camilla; Tonby, Kristian; Pischke, Soeren; Jenum, Synne; Skeie, Linda Gail; Nur, Sarah; Lind, Andreas; Opsand, Hanne; Enersen, Tone Burvald; Grøndahl, Ragnhild; Hermann, Anne; Dudman, Susanne Gjeruldsen; Müller, Fredrik; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma (Journal article; Peer reviewed, 2020-12)
      In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and ...
    • Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity 

      Holmøy, Trygve; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Myhr, Kjell-Morten; Michelsen, Annika; Aukrust, Pål; Ueland, Thor (Peer reviewed; Journal article, 2013-09-19)
      Background. Serum markers of inflammation are candidate biomarkers in multiple sclerosis (MS). ω-3 fatty acids are suggested to have anti-inflammatory properties that might be beneficial in MS. We aimed to explore the ...
    • IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy 

      Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Peer reviewed; Journal article, 2015-04)
      Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ...
    • Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study 

      Husebø, Gunnar Reksten; Bakke, Per; Aanerud, Marianne; Hardie, Jon Andrew; Ueland, Thor; Grønseth, Rune; Persson, Louise Jeanette Pauline; Aukrust, Pål; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2014-10-03)
      Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ...
    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Peer reviewed; Journal article, 2019-01-17)
      Common variable immunodefciency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic infammation and ten “key” bacteria ...
    • Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria 

      Otterdal, Kari; Berg, Åse; Michelsen, Annika; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Fevang, Børre; Aukrust, Pål; Langeland, Nina; Ueland, Thor (Peer reviewed; Journal article, 2018-12-18)
      BACKGROUND: The immune response during P. falciparum infection is a two-edged sword, involving dysregulation of the inflammatory responses with several types of immune cells participating. Here we examined T-cell, ...
    • A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue 

      Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R.; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2017-07)
      Objective: A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to the pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) and related comorbidities. We investigated the relative ...
    • Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study 

      Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Hartmann, Anders; Skadberg, Øyvind; Brede, Cato; Ueland, Thor; Pasch, Andreas; Reisæter, Anna Varberg; Gøransson, Lasse (Peer reviewed; Journal article, 2019)
      Background: Short‐term survival after kidney transplantation is excellent, but long‐term survival remains low and is equivalent to non‐end‐stage renal disease patients with many invasive malignancies. The aim of the study ...
    • Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD 

      Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Michelsen, Annika; Ueland, Thor; Hardie, Jon Andrew; Aukrust, Pål; Bakke, Per S.; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2015-03-24)
      Background: Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on ...